Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference

Autores
Croci Russo, Diego Omar; Rabinovich, Gabriel Adrián
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.
Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
Galectin 1
Angiogenesis
Vegf
Glycans
Cancer Immunotherapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7610
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7610
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the differenceCroci Russo, Diego OmarRabinovich, Gabriel AdriánGalectin 1AngiogenesisVegfGlycansCancer Immunotherapyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaLandes Bioscience2014-06-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7610Croci Russo, Diego Omar; Rabinovich, Gabriel Adrián; Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference; Landes Bioscience; OncoImmunology; 3; 6; 25-6-2014; e29380-e293802162-4011enginfo:eu-repo/semantics/altIdentifier/doi/10.4161/onci.29380info:eu-repo/semantics/altIdentifier/url/www.tandfonline.com/doi/abs/10.4161/onci.29380info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:56Zoai:ri.conicet.gov.ar:11336/7610instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:57.07CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
title Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
spellingShingle Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
Croci Russo, Diego Omar
Galectin 1
Angiogenesis
Vegf
Glycans
Cancer Immunotherapy
title_short Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
title_full Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
title_fullStr Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
title_full_unstemmed Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
title_sort Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
dc.creator.none.fl_str_mv Croci Russo, Diego Omar
Rabinovich, Gabriel Adrián
author Croci Russo, Diego Omar
author_facet Croci Russo, Diego Omar
Rabinovich, Gabriel Adrián
author_role author
author2 Rabinovich, Gabriel Adrián
author2_role author
dc.subject.none.fl_str_mv Galectin 1
Angiogenesis
Vegf
Glycans
Cancer Immunotherapy
topic Galectin 1
Angiogenesis
Vegf
Glycans
Cancer Immunotherapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.
Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7610
Croci Russo, Diego Omar; Rabinovich, Gabriel Adrián; Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference; Landes Bioscience; OncoImmunology; 3; 6; 25-6-2014; e29380-e29380
2162-4011
url http://hdl.handle.net/11336/7610
identifier_str_mv Croci Russo, Diego Omar; Rabinovich, Gabriel Adrián; Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference; Landes Bioscience; OncoImmunology; 3; 6; 25-6-2014; e29380-e29380
2162-4011
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4161/onci.29380
info:eu-repo/semantics/altIdentifier/url/www.tandfonline.com/doi/abs/10.4161/onci.29380
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268826938376192
score 13.13397

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