Fe(III) salEen derived Schiff base complexes as potential contrast agents

Autores
Cardoso, Bernardo de P.; Vicente, Ana I.; Ward, Joseph B. J.; Sebastião, Pedro J.; Vaca Chávez Fornasero, Fabián; Barroso, Sónia; Carvalho, Alexandra; Keely, Stephen J.; Martinho, Paulo N.; Calhorda, Maria José
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl)salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and 2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of their magnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from 0.35 to 0.80 mM-1 s-1 for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with those known for other iron(III) based contrast agents. Biological studies on colonic epithelial T84 cell monolayers showed that the compounds exert toxic effects only at concentrations higher than 100 μM while coincidently reducing colonic epithelial secretory function. These two features make these complexes good candidates for further development in order to be used as MRI contrast agents.
Fil: Cardoso, Bernardo de P.. Universidade de Lisboa; Portugal
Fil: Vicente, Ana I.. Universidade de Lisboa; Portugal
Fil: Ward, Joseph B. J.. Beaumont Hospital; Irlanda
Fil: Sebastião, Pedro J.. Universidade de Lisboa; Portugal
Fil: Vaca Chávez Fornasero, Fabián. Universidade de Lisboa; Portugal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Barroso, Sónia. Universidade de Lisboa; Portugal
Fil: Carvalho, Alexandra. Universidade Nova de Lisboa; Portugal
Fil: Keely, Stephen J.. Beaumont Hospital; Irlanda
Fil: Martinho, Paulo N.. Universidade de Lisboa; Portugal
Fil: Calhorda, Maria José. Universidade de Lisboa; Portugal
Materia
Cell Toxicity
Contrast Agent
Evans' Method
Fe(Iii) Complexes
Nmrd
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/50590
Acceder
id CONICETDig_6e1cccecbddb6bb5a0f12c1ded5a1cac
oai_identifier_str oai:ri.conicet.gov.ar:11336/50590
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fe(III) salEen derived Schiff base complexes as potential contrast agentsCardoso, Bernardo de P.Vicente, Ana I.Ward, Joseph B. J.Sebastião, Pedro J.Vaca Chávez Fornasero, FabiánBarroso, SóniaCarvalho, AlexandraKeely, Stephen J.Martinho, Paulo N.Calhorda, Maria JoséCell ToxicityContrast AgentEvans' MethodFe(Iii) ComplexesNmrdhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl)salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and 2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of their magnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from 0.35 to 0.80 mM-1 s-1 for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with those known for other iron(III) based contrast agents. Biological studies on colonic epithelial T84 cell monolayers showed that the compounds exert toxic effects only at concentrations higher than 100 μM while coincidently reducing colonic epithelial secretory function. These two features make these complexes good candidates for further development in order to be used as MRI contrast agents.Fil: Cardoso, Bernardo de P.. Universidade de Lisboa; PortugalFil: Vicente, Ana I.. Universidade de Lisboa; PortugalFil: Ward, Joseph B. J.. Beaumont Hospital; IrlandaFil: Sebastião, Pedro J.. Universidade de Lisboa; PortugalFil: Vaca Chávez Fornasero, Fabián. Universidade de Lisboa; Portugal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Barroso, Sónia. Universidade de Lisboa; PortugalFil: Carvalho, Alexandra. Universidade Nova de Lisboa; PortugalFil: Keely, Stephen J.. Beaumont Hospital; IrlandaFil: Martinho, Paulo N.. Universidade de Lisboa; PortugalFil: Calhorda, Maria José. Universidade de Lisboa; PortugalElsevier Science Sa2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50590Cardoso, Bernardo de P.; Vicente, Ana I.; Ward, Joseph B. J.; Sebastião, Pedro J.; Vaca Chávez Fornasero, Fabián; et al.; Fe(III) salEen derived Schiff base complexes as potential contrast agents; Elsevier Science Sa; Inorganica Chimica Acta; 432; 5-2015; 258-2660020-1693CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2015.04.026info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0020169315002145info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:07Zoai:ri.conicet.gov.ar:11336/50590instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:07.985CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fe(III) salEen derived Schiff base complexes as potential contrast agents
title Fe(III) salEen derived Schiff base complexes as potential contrast agents
spellingShingle Fe(III) salEen derived Schiff base complexes as potential contrast agents
Cardoso, Bernardo de P.
Cell Toxicity
Contrast Agent
Evans' Method
Fe(Iii) Complexes
Nmrd
title_short Fe(III) salEen derived Schiff base complexes as potential contrast agents
title_full Fe(III) salEen derived Schiff base complexes as potential contrast agents
title_fullStr Fe(III) salEen derived Schiff base complexes as potential contrast agents
title_full_unstemmed Fe(III) salEen derived Schiff base complexes as potential contrast agents
title_sort Fe(III) salEen derived Schiff base complexes as potential contrast agents
dc.creator.none.fl_str_mv Cardoso, Bernardo de P.
Vicente, Ana I.
Ward, Joseph B. J.
Sebastião, Pedro J.
Vaca Chávez Fornasero, Fabián
Barroso, Sónia
Carvalho, Alexandra
Keely, Stephen J.
Martinho, Paulo N.
Calhorda, Maria José
author Cardoso, Bernardo de P.
author_facet Cardoso, Bernardo de P.
Vicente, Ana I.
Ward, Joseph B. J.
Sebastião, Pedro J.
Vaca Chávez Fornasero, Fabián
Barroso, Sónia
Carvalho, Alexandra
Keely, Stephen J.
Martinho, Paulo N.
Calhorda, Maria José
author_role author
author2 Vicente, Ana I.
Ward, Joseph B. J.
Sebastião, Pedro J.
Vaca Chávez Fornasero, Fabián
Barroso, Sónia
Carvalho, Alexandra
Keely, Stephen J.
Martinho, Paulo N.
Calhorda, Maria José
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cell Toxicity
Contrast Agent
Evans' Method
Fe(Iii) Complexes
Nmrd
topic Cell Toxicity
Contrast Agent
Evans' Method
Fe(Iii) Complexes
Nmrd
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl)salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and 2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of their magnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from 0.35 to 0.80 mM-1 s-1 for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with those known for other iron(III) based contrast agents. Biological studies on colonic epithelial T84 cell monolayers showed that the compounds exert toxic effects only at concentrations higher than 100 μM while coincidently reducing colonic epithelial secretory function. These two features make these complexes good candidates for further development in order to be used as MRI contrast agents.
Fil: Cardoso, Bernardo de P.. Universidade de Lisboa; Portugal
Fil: Vicente, Ana I.. Universidade de Lisboa; Portugal
Fil: Ward, Joseph B. J.. Beaumont Hospital; Irlanda
Fil: Sebastião, Pedro J.. Universidade de Lisboa; Portugal
Fil: Vaca Chávez Fornasero, Fabián. Universidade de Lisboa; Portugal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Barroso, Sónia. Universidade de Lisboa; Portugal
Fil: Carvalho, Alexandra. Universidade Nova de Lisboa; Portugal
Fil: Keely, Stephen J.. Beaumont Hospital; Irlanda
Fil: Martinho, Paulo N.. Universidade de Lisboa; Portugal
Fil: Calhorda, Maria José. Universidade de Lisboa; Portugal
description Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl)salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and 2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of their magnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from 0.35 to 0.80 mM-1 s-1 for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with those known for other iron(III) based contrast agents. Biological studies on colonic epithelial T84 cell monolayers showed that the compounds exert toxic effects only at concentrations higher than 100 μM while coincidently reducing colonic epithelial secretory function. These two features make these complexes good candidates for further development in order to be used as MRI contrast agents.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/50590
Cardoso, Bernardo de P.; Vicente, Ana I.; Ward, Joseph B. J.; Sebastião, Pedro J.; Vaca Chávez Fornasero, Fabián; et al.; Fe(III) salEen derived Schiff base complexes as potential contrast agents; Elsevier Science Sa; Inorganica Chimica Acta; 432; 5-2015; 258-266
0020-1693
CONICET Digital
CONICET
url http://hdl.handle.net/11336/50590
identifier_str_mv Cardoso, Bernardo de P.; Vicente, Ana I.; Ward, Joseph B. J.; Sebastião, Pedro J.; Vaca Chávez Fornasero, Fabián; et al.; Fe(III) salEen derived Schiff base complexes as potential contrast agents; Elsevier Science Sa; Inorganica Chimica Acta; 432; 5-2015; 258-266
0020-1693
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2015.04.026
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0020169315002145
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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