Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study

Autores
Martinez Moro, Marta; Jenczyk, Jacek; Giussi, Juan Martín; Jurga, Stefan; Moya, Sergio E.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hypothesis: Hydrogels of N-isopropylacrylamide and methacrylic acid (P(NIPAm-co-MAA)) display pH sensitivity and complex positively charged molecules through carboxylate groups, while having a critical solution temperature at which they reduce in volume and dehydrate. We aimed to elucidate how the responsiveness of MAA to environmental changes alters PNIPAm hydrogels at the molecular level using nuclear magnetic resonance (NMR). Time-lapse NMR allows us to follow the evolution of NMR signal under a temperature stimulus, providing unique information on conformational freedom of the hydrogel polymers. Experiments: We used time-lapse NMR to follow the evolution of the NMR signal with time over a temperature change from 25 to 40 °C and to study the swelling/deswelling kinetics of P(NIPAm-co-MAA) microgels at different pH values and ionic strengths, and in the presence of positively charged molecules complexing carboxylate groups. Findings: At acid pH, hydrogel collapse is favored over neutral pH, and at basic pH the carboxylates remain steadily hydrated during temperature increase. Increasing ionic strength results in a faster, more effective collapse than decreasing pH. Complexation of medium-sized molecules with several charges (spermine, spermidine) causes a faster collapse than complexation with large molecular weight poly(allylamine) hydrochloride, but similar to the collapse effected by large poly(diallyldimethylammonium) chloride. This work opens new perspectives to using time-lapse NMR to study thermoresponsive systems that respond to multiple stimuli, with particular relevance in designing hydrogels for drug delivery.
Fil: Martinez Moro, Marta. Basque Research and Technology Alliance; España
Fil: Jenczyk, Jacek. Adam Mickiewicz University; Polonia
Fil: Giussi, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Jurga, Stefan. Adam Mickiewicz University; Polonia
Fil: Moya, Sergio E.. Basque Research and Technology Alliance; España
Materia
DESWELLING KINETICS
HYDROGEL COLLAPSE
NIPAM-MAA MICROGELS
POLYAMINES
TIME-LAPSE NMR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/171942
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/171942
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR studyMartinez Moro, MartaJenczyk, JacekGiussi, Juan MartínJurga, StefanMoya, Sergio E.DESWELLING KINETICSHYDROGEL COLLAPSENIPAM-MAA MICROGELSPOLYAMINESTIME-LAPSE NMRhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Hypothesis: Hydrogels of N-isopropylacrylamide and methacrylic acid (P(NIPAm-co-MAA)) display pH sensitivity and complex positively charged molecules through carboxylate groups, while having a critical solution temperature at which they reduce in volume and dehydrate. We aimed to elucidate how the responsiveness of MAA to environmental changes alters PNIPAm hydrogels at the molecular level using nuclear magnetic resonance (NMR). Time-lapse NMR allows us to follow the evolution of NMR signal under a temperature stimulus, providing unique information on conformational freedom of the hydrogel polymers. Experiments: We used time-lapse NMR to follow the evolution of the NMR signal with time over a temperature change from 25 to 40 °C and to study the swelling/deswelling kinetics of P(NIPAm-co-MAA) microgels at different pH values and ionic strengths, and in the presence of positively charged molecules complexing carboxylate groups. Findings: At acid pH, hydrogel collapse is favored over neutral pH, and at basic pH the carboxylates remain steadily hydrated during temperature increase. Increasing ionic strength results in a faster, more effective collapse than decreasing pH. Complexation of medium-sized molecules with several charges (spermine, spermidine) causes a faster collapse than complexation with large molecular weight poly(allylamine) hydrochloride, but similar to the collapse effected by large poly(diallyldimethylammonium) chloride. This work opens new perspectives to using time-lapse NMR to study thermoresponsive systems that respond to multiple stimuli, with particular relevance in designing hydrogels for drug delivery.Fil: Martinez Moro, Marta. Basque Research and Technology Alliance; EspañaFil: Jenczyk, Jacek. Adam Mickiewicz University; PoloniaFil: Giussi, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Jurga, Stefan. Adam Mickiewicz University; PoloniaFil: Moya, Sergio E.. Basque Research and Technology Alliance; EspañaElsevier2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171942Martinez Moro, Marta; Jenczyk, Jacek; Giussi, Juan Martín; Jurga, Stefan; Moya, Sergio E.; Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study; Elsevier; Journal of Colloid and Interface Science; 580; 11-2020; 439-4480021-9797CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021979720309279info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcis.2020.07.049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:04Zoai:ri.conicet.gov.ar:11336/171942instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:04.565CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
title Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
spellingShingle Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
Martinez Moro, Marta
DESWELLING KINETICS
HYDROGEL COLLAPSE
NIPAM-MAA MICROGELS
POLYAMINES
TIME-LAPSE NMR
title_short Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
title_full Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
title_fullStr Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
title_full_unstemmed Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
title_sort Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
dc.creator.none.fl_str_mv Martinez Moro, Marta
Jenczyk, Jacek
Giussi, Juan Martín
Jurga, Stefan
Moya, Sergio E.
author Martinez Moro, Marta
author_facet Martinez Moro, Marta
Jenczyk, Jacek
Giussi, Juan Martín
Jurga, Stefan
Moya, Sergio E.
author_role author
author2 Jenczyk, Jacek
Giussi, Juan Martín
Jurga, Stefan
Moya, Sergio E.
author2_role author
author
author
author
dc.subject.none.fl_str_mv DESWELLING KINETICS
HYDROGEL COLLAPSE
NIPAM-MAA MICROGELS
POLYAMINES
TIME-LAPSE NMR
topic DESWELLING KINETICS
HYDROGEL COLLAPSE
NIPAM-MAA MICROGELS
POLYAMINES
TIME-LAPSE NMR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Hypothesis: Hydrogels of N-isopropylacrylamide and methacrylic acid (P(NIPAm-co-MAA)) display pH sensitivity and complex positively charged molecules through carboxylate groups, while having a critical solution temperature at which they reduce in volume and dehydrate. We aimed to elucidate how the responsiveness of MAA to environmental changes alters PNIPAm hydrogels at the molecular level using nuclear magnetic resonance (NMR). Time-lapse NMR allows us to follow the evolution of NMR signal under a temperature stimulus, providing unique information on conformational freedom of the hydrogel polymers. Experiments: We used time-lapse NMR to follow the evolution of the NMR signal with time over a temperature change from 25 to 40 °C and to study the swelling/deswelling kinetics of P(NIPAm-co-MAA) microgels at different pH values and ionic strengths, and in the presence of positively charged molecules complexing carboxylate groups. Findings: At acid pH, hydrogel collapse is favored over neutral pH, and at basic pH the carboxylates remain steadily hydrated during temperature increase. Increasing ionic strength results in a faster, more effective collapse than decreasing pH. Complexation of medium-sized molecules with several charges (spermine, spermidine) causes a faster collapse than complexation with large molecular weight poly(allylamine) hydrochloride, but similar to the collapse effected by large poly(diallyldimethylammonium) chloride. This work opens new perspectives to using time-lapse NMR to study thermoresponsive systems that respond to multiple stimuli, with particular relevance in designing hydrogels for drug delivery.
Fil: Martinez Moro, Marta. Basque Research and Technology Alliance; España
Fil: Jenczyk, Jacek. Adam Mickiewicz University; Polonia
Fil: Giussi, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Jurga, Stefan. Adam Mickiewicz University; Polonia
Fil: Moya, Sergio E.. Basque Research and Technology Alliance; España
description Hypothesis: Hydrogels of N-isopropylacrylamide and methacrylic acid (P(NIPAm-co-MAA)) display pH sensitivity and complex positively charged molecules through carboxylate groups, while having a critical solution temperature at which they reduce in volume and dehydrate. We aimed to elucidate how the responsiveness of MAA to environmental changes alters PNIPAm hydrogels at the molecular level using nuclear magnetic resonance (NMR). Time-lapse NMR allows us to follow the evolution of NMR signal under a temperature stimulus, providing unique information on conformational freedom of the hydrogel polymers. Experiments: We used time-lapse NMR to follow the evolution of the NMR signal with time over a temperature change from 25 to 40 °C and to study the swelling/deswelling kinetics of P(NIPAm-co-MAA) microgels at different pH values and ionic strengths, and in the presence of positively charged molecules complexing carboxylate groups. Findings: At acid pH, hydrogel collapse is favored over neutral pH, and at basic pH the carboxylates remain steadily hydrated during temperature increase. Increasing ionic strength results in a faster, more effective collapse than decreasing pH. Complexation of medium-sized molecules with several charges (spermine, spermidine) causes a faster collapse than complexation with large molecular weight poly(allylamine) hydrochloride, but similar to the collapse effected by large poly(diallyldimethylammonium) chloride. This work opens new perspectives to using time-lapse NMR to study thermoresponsive systems that respond to multiple stimuli, with particular relevance in designing hydrogels for drug delivery.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171942
Martinez Moro, Marta; Jenczyk, Jacek; Giussi, Juan Martín; Jurga, Stefan; Moya, Sergio E.; Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study; Elsevier; Journal of Colloid and Interface Science; 580; 11-2020; 439-448
0021-9797
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171942
identifier_str_mv Martinez Moro, Marta; Jenczyk, Jacek; Giussi, Juan Martín; Jurga, Stefan; Moya, Sergio E.; Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study; Elsevier; Journal of Colloid and Interface Science; 580; 11-2020; 439-448
0021-9797
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021979720309279
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcis.2020.07.049
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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