Effects of rotigotine on Parkinson´s disease-related sleep disturbances

Autores
Antonini, Angelo; Calandrella, Daniela; Merello, Marcelo Jorge; Konstantinos, Koutsikos; Pilleri, Manuela
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
INTRODUCTION: Sleep abnormalities are a frequent non-motor symptom and a prominent cause of disability in patients with Parkinson's disease (PD). AREAS COVERED: This review discusses what is currently known about the characteristics of sleep disturbances in PD patients and attempts to clarify the role of dopaminergic pathways in their pathogenesis as well as the beneficial effect of dopaminergic agents in their treatment. In particular, this review will focus on the effects of transdermal rotigotine on improving PD-related sleep disorders. EXPERT OPINION: Sleep disturbances are common in PD, and these disturbances can be reduced or resolved, in large part, by preventing or attenuating nocturnal and early morning motor and non-motor symptoms of PD. The studies discussed within this review suggest that sleep disorders are not just a consequence of motor impairment and dopaminergic therapy but are an integral part of the neurodegenerative process of PD. This is supported by the appearance of specific sleep disturbances, which are related to degeneration of the brainstem areas involved in the regulation of sleep/wake states in advance of typical PD symptoms. Development of more detailed diagnostic tools aimed at detecting sleep disturbances and at defining the main causative factors of sleep disturbances in PD will lead to improved treatment of these disturbances.
Fil: Antonini, Angelo. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; Italia
Fil: Calandrella, Daniela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; Italia
Fil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Konstantinos, Koutsikos. Università di Padova; Italia
Fil: Pilleri, Manuela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorder; Italia
Materia
Dopamine
Rotigotine
Parkinson´S Disease
Sleep Disturbance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28254
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/28254
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of rotigotine on Parkinson´s disease-related sleep disturbancesAntonini, AngeloCalandrella, DanielaMerello, Marcelo JorgeKonstantinos, KoutsikosPilleri, ManuelaDopamineRotigotineParkinson´S DiseaseSleep Disturbancehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3INTRODUCTION: Sleep abnormalities are a frequent non-motor symptom and a prominent cause of disability in patients with Parkinson's disease (PD). AREAS COVERED: This review discusses what is currently known about the characteristics of sleep disturbances in PD patients and attempts to clarify the role of dopaminergic pathways in their pathogenesis as well as the beneficial effect of dopaminergic agents in their treatment. In particular, this review will focus on the effects of transdermal rotigotine on improving PD-related sleep disorders. EXPERT OPINION: Sleep disturbances are common in PD, and these disturbances can be reduced or resolved, in large part, by preventing or attenuating nocturnal and early morning motor and non-motor symptoms of PD. The studies discussed within this review suggest that sleep disorders are not just a consequence of motor impairment and dopaminergic therapy but are an integral part of the neurodegenerative process of PD. This is supported by the appearance of specific sleep disturbances, which are related to degeneration of the brainstem areas involved in the regulation of sleep/wake states in advance of typical PD symptoms. Development of more detailed diagnostic tools aimed at detecting sleep disturbances and at defining the main causative factors of sleep disturbances in PD will lead to improved treatment of these disturbances.Fil: Antonini, Angelo. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; ItaliaFil: Calandrella, Daniela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; ItaliaFil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Konstantinos, Koutsikos. Università di Padova; ItaliaFil: Pilleri, Manuela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorder; ItaliaTaylor & Francis2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28254Antonini, Angelo; Calandrella, Daniela; Merello, Marcelo Jorge; Konstantinos, Koutsikos; Pilleri, Manuela; Effects of rotigotine on Parkinson´s disease-related sleep disturbances; Taylor & Francis; Expert Opinion On Therapeutic Targets; 14; 18; 12-2013; 2571-25801472-8222CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1517/14656566.2013.849692info:eu-repo/semantics/altIdentifier/doi/10.1517/14656566.2013.849692info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:25Zoai:ri.conicet.gov.ar:11336/28254instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:25.446CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of rotigotine on Parkinson´s disease-related sleep disturbances
title Effects of rotigotine on Parkinson´s disease-related sleep disturbances
spellingShingle Effects of rotigotine on Parkinson´s disease-related sleep disturbances
Antonini, Angelo
Dopamine
Rotigotine
Parkinson´S Disease
Sleep Disturbance
title_short Effects of rotigotine on Parkinson´s disease-related sleep disturbances
title_full Effects of rotigotine on Parkinson´s disease-related sleep disturbances
title_fullStr Effects of rotigotine on Parkinson´s disease-related sleep disturbances
title_full_unstemmed Effects of rotigotine on Parkinson´s disease-related sleep disturbances
title_sort Effects of rotigotine on Parkinson´s disease-related sleep disturbances
dc.creator.none.fl_str_mv Antonini, Angelo
Calandrella, Daniela
Merello, Marcelo Jorge
Konstantinos, Koutsikos
Pilleri, Manuela
author Antonini, Angelo
author_facet Antonini, Angelo
Calandrella, Daniela
Merello, Marcelo Jorge
Konstantinos, Koutsikos
Pilleri, Manuela
author_role author
author2 Calandrella, Daniela
Merello, Marcelo Jorge
Konstantinos, Koutsikos
Pilleri, Manuela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Dopamine
Rotigotine
Parkinson´S Disease
Sleep Disturbance
topic Dopamine
Rotigotine
Parkinson´S Disease
Sleep Disturbance
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv INTRODUCTION: Sleep abnormalities are a frequent non-motor symptom and a prominent cause of disability in patients with Parkinson's disease (PD). AREAS COVERED: This review discusses what is currently known about the characteristics of sleep disturbances in PD patients and attempts to clarify the role of dopaminergic pathways in their pathogenesis as well as the beneficial effect of dopaminergic agents in their treatment. In particular, this review will focus on the effects of transdermal rotigotine on improving PD-related sleep disorders. EXPERT OPINION: Sleep disturbances are common in PD, and these disturbances can be reduced or resolved, in large part, by preventing or attenuating nocturnal and early morning motor and non-motor symptoms of PD. The studies discussed within this review suggest that sleep disorders are not just a consequence of motor impairment and dopaminergic therapy but are an integral part of the neurodegenerative process of PD. This is supported by the appearance of specific sleep disturbances, which are related to degeneration of the brainstem areas involved in the regulation of sleep/wake states in advance of typical PD symptoms. Development of more detailed diagnostic tools aimed at detecting sleep disturbances and at defining the main causative factors of sleep disturbances in PD will lead to improved treatment of these disturbances.
Fil: Antonini, Angelo. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; Italia
Fil: Calandrella, Daniela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; Italia
Fil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Konstantinos, Koutsikos. Università di Padova; Italia
Fil: Pilleri, Manuela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorder; Italia
description INTRODUCTION: Sleep abnormalities are a frequent non-motor symptom and a prominent cause of disability in patients with Parkinson's disease (PD). AREAS COVERED: This review discusses what is currently known about the characteristics of sleep disturbances in PD patients and attempts to clarify the role of dopaminergic pathways in their pathogenesis as well as the beneficial effect of dopaminergic agents in their treatment. In particular, this review will focus on the effects of transdermal rotigotine on improving PD-related sleep disorders. EXPERT OPINION: Sleep disturbances are common in PD, and these disturbances can be reduced or resolved, in large part, by preventing or attenuating nocturnal and early morning motor and non-motor symptoms of PD. The studies discussed within this review suggest that sleep disorders are not just a consequence of motor impairment and dopaminergic therapy but are an integral part of the neurodegenerative process of PD. This is supported by the appearance of specific sleep disturbances, which are related to degeneration of the brainstem areas involved in the regulation of sleep/wake states in advance of typical PD symptoms. Development of more detailed diagnostic tools aimed at detecting sleep disturbances and at defining the main causative factors of sleep disturbances in PD will lead to improved treatment of these disturbances.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28254
Antonini, Angelo; Calandrella, Daniela; Merello, Marcelo Jorge; Konstantinos, Koutsikos; Pilleri, Manuela; Effects of rotigotine on Parkinson´s disease-related sleep disturbances; Taylor & Francis; Expert Opinion On Therapeutic Targets; 14; 18; 12-2013; 2571-2580
1472-8222
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28254
identifier_str_mv Antonini, Angelo; Calandrella, Daniela; Merello, Marcelo Jorge; Konstantinos, Koutsikos; Pilleri, Manuela; Effects of rotigotine on Parkinson´s disease-related sleep disturbances; Taylor & Francis; Expert Opinion On Therapeutic Targets; 14; 18; 12-2013; 2571-2580
1472-8222
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1517/14656566.2013.849692
info:eu-repo/semantics/altIdentifier/doi/10.1517/14656566.2013.849692
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268857610272768
score 13.13397

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