Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis
- Autores
- Solana, Maria Elisa; Ferrer, Maria Florencia; Novoa, María Mercedes; Song, Wen Chao; Gomez, Ricardo Martin
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Experimental murine infection with trypanosoma cruzi (TC) has been proposed as a model of human inflammatory idiopathic myositis to study the role of T-cells in its pathogenesis. Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity via increased expression of cytokines, including interferon-ã. Methods: To determine whether Daf1 deficiency can exacerbate TC-induced myositis, C57BL/6 Daf1+/+ and Daf1-/- mice were inoculated with 105 trypomastigotes and their morbility, parasitaemia, histopathology, and T-cellexpansion were studied in the acute and chronic stages. Results: Daf1-/- mice presented lower parasitaemia but higher morbidity, muscle histopathology, and increased spleen number of CD44+ (activated/memoryphenotype) CD4+ and CD8+ T cells. Discussion: An enhanced CD8+ T cell immune specific response may explain the lower parasitaemia levels and the increase in histopathological lesions. We propose the TC-inoculated Daf1-/- mice as a useful model to study T-cellmediatedimmunity in skeletal muscle tissues.
Fil: Solana, Maria Elisa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; Argentina
Fil: Ferrer, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Novoa, María Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; Argentina
Fil: Song, Wen Chao. University of Pennsylvania; Estados Unidos
Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina - Materia
-
Chagas disease
chronic miositis
DAF-KO mice
pathogenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/271280
Ver los metadatos del registro completo
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Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositisSolana, Maria ElisaFerrer, Maria FlorenciaNovoa, María MercedesSong, Wen ChaoGomez, Ricardo MartinChagas diseasechronic miositisDAF-KO micepathogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Introduction: Experimental murine infection with trypanosoma cruzi (TC) has been proposed as a model of human inflammatory idiopathic myositis to study the role of T-cells in its pathogenesis. Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity via increased expression of cytokines, including interferon-ã. Methods: To determine whether Daf1 deficiency can exacerbate TC-induced myositis, C57BL/6 Daf1+/+ and Daf1-/- mice were inoculated with 105 trypomastigotes and their morbility, parasitaemia, histopathology, and T-cellexpansion were studied in the acute and chronic stages. Results: Daf1-/- mice presented lower parasitaemia but higher morbidity, muscle histopathology, and increased spleen number of CD44+ (activated/memoryphenotype) CD4+ and CD8+ T cells. Discussion: An enhanced CD8+ T cell immune specific response may explain the lower parasitaemia levels and the increase in histopathological lesions. We propose the TC-inoculated Daf1-/- mice as a useful model to study T-cellmediatedimmunity in skeletal muscle tissues.Fil: Solana, Maria Elisa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; ArgentinaFil: Ferrer, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Novoa, María Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; ArgentinaFil: Song, Wen Chao. University of Pennsylvania; Estados UnidosFil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaJohn Wiley & Sons2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271280Solana, Maria Elisa; Ferrer, Maria Florencia; Novoa, María Mercedes; Song, Wen Chao; Gomez, Ricardo Martin; Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis; John Wiley & Sons; Muscle & Nerve; 46; 4; 9-2012; 582-5870148-639XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/mus.23347info:eu-repo/semantics/altIdentifier/doi/10.1002/mus.23347info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:27Zoai:ri.conicet.gov.ar:11336/271280instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:27.593CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
title |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
spellingShingle |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis Solana, Maria Elisa Chagas disease chronic miositis DAF-KO mice pathogenesis |
title_short |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
title_full |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
title_fullStr |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
title_full_unstemmed |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
title_sort |
Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis |
dc.creator.none.fl_str_mv |
Solana, Maria Elisa Ferrer, Maria Florencia Novoa, María Mercedes Song, Wen Chao Gomez, Ricardo Martin |
author |
Solana, Maria Elisa |
author_facet |
Solana, Maria Elisa Ferrer, Maria Florencia Novoa, María Mercedes Song, Wen Chao Gomez, Ricardo Martin |
author_role |
author |
author2 |
Ferrer, Maria Florencia Novoa, María Mercedes Song, Wen Chao Gomez, Ricardo Martin |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Chagas disease chronic miositis DAF-KO mice pathogenesis |
topic |
Chagas disease chronic miositis DAF-KO mice pathogenesis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Experimental murine infection with trypanosoma cruzi (TC) has been proposed as a model of human inflammatory idiopathic myositis to study the role of T-cells in its pathogenesis. Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity via increased expression of cytokines, including interferon-ã. Methods: To determine whether Daf1 deficiency can exacerbate TC-induced myositis, C57BL/6 Daf1+/+ and Daf1-/- mice were inoculated with 105 trypomastigotes and their morbility, parasitaemia, histopathology, and T-cellexpansion were studied in the acute and chronic stages. Results: Daf1-/- mice presented lower parasitaemia but higher morbidity, muscle histopathology, and increased spleen number of CD44+ (activated/memoryphenotype) CD4+ and CD8+ T cells. Discussion: An enhanced CD8+ T cell immune specific response may explain the lower parasitaemia levels and the increase in histopathological lesions. We propose the TC-inoculated Daf1-/- mice as a useful model to study T-cellmediatedimmunity in skeletal muscle tissues. Fil: Solana, Maria Elisa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; Argentina Fil: Ferrer, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Novoa, María Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; Argentina Fil: Song, Wen Chao. University of Pennsylvania; Estados Unidos Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina |
description |
Introduction: Experimental murine infection with trypanosoma cruzi (TC) has been proposed as a model of human inflammatory idiopathic myositis to study the role of T-cells in its pathogenesis. Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity via increased expression of cytokines, including interferon-ã. Methods: To determine whether Daf1 deficiency can exacerbate TC-induced myositis, C57BL/6 Daf1+/+ and Daf1-/- mice were inoculated with 105 trypomastigotes and their morbility, parasitaemia, histopathology, and T-cellexpansion were studied in the acute and chronic stages. Results: Daf1-/- mice presented lower parasitaemia but higher morbidity, muscle histopathology, and increased spleen number of CD44+ (activated/memoryphenotype) CD4+ and CD8+ T cells. Discussion: An enhanced CD8+ T cell immune specific response may explain the lower parasitaemia levels and the increase in histopathological lesions. We propose the TC-inoculated Daf1-/- mice as a useful model to study T-cellmediatedimmunity in skeletal muscle tissues. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/271280 Solana, Maria Elisa; Ferrer, Maria Florencia; Novoa, María Mercedes; Song, Wen Chao; Gomez, Ricardo Martin; Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis; John Wiley & Sons; Muscle & Nerve; 46; 4; 9-2012; 582-587 0148-639X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/271280 |
identifier_str_mv |
Solana, Maria Elisa; Ferrer, Maria Florencia; Novoa, María Mercedes; Song, Wen Chao; Gomez, Ricardo Martin; Decay‐accelerating factor 1 deficiency exacerbates Trypanosoma cruzi ‐induced murine chronic myositis; John Wiley & Sons; Muscle & Nerve; 46; 4; 9-2012; 582-587 0148-639X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/mus.23347 info:eu-repo/semantics/altIdentifier/doi/10.1002/mus.23347 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons |
publisher.none.fl_str_mv |
John Wiley & Sons |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |