Cortical Auditory Adaptation in the Awake Rat and the Role of Potassium Currents

• Autores: Abolafia, Juan M.; Vergara, Ramiro Oscar; Arnold, M. M.; Reig, R.; Sanchez Vives, M. V.
• Año de publicación: 2011
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: AUDITORY CIRCUITS; AUDITORY CORTEX; AUDITORY PROCESSING; CORTICAL SLICES; FORWARD MASKING; FORWARD SUPPRESSION; IN VITRO CORTEX; INTRINSIC PROPERTIES; POTASSIUM CHANNELS; SENSORY ADAPTATION
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Responses to sound in the auditory cortex are influenced by the preceding history of firing. We studied the time course of auditory adaptation in primary auditory cortex (A1) from awake, freely moving rats. Two identical stimuli were delivered with different intervals ranging from 50 ms to 8 s. Single neuron recordings in the awake animal revealed that the response to a sound is influenced by sounds delivered even several seconds earlier, the second one usually yielding a weaker response. To understand the role of neuronal intrinsic properties in this phenomenon, we obtained intracellular recordings from rat A1 neurons in vitro and mimicked the same protocols of adaptation carried out in awake animals by means of depolarizing pulses of identical duration and intervals. The intensity of the pulses was adjusted such that the first pulse would evoke a similar number of spikes as its equivalent in vivo. A1 neurons in vitro adapted with a similar time course but less than in awake animals. At least two potassium currents participated in the in vitro adaptation: a Na +-dependent K + current and an apamin-sensitive K + current. Our results suggest that potassium currents underlie at least part of cortical auditory adaptation during the awake state.
Fil: Abolafia, Juan M.. INSTITUTO DE INVESTIGACIONES BIOMEDICAS AUGUST PI I SUNYER (IDIBAPS);
Fil: Vergara, Ramiro Oscar. INSTITUTO DE INVESTIGACIONES BIOMEDICAS AUGUST PI I SUNYER (IDIBAPS); . Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arnold, M. M.. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. INSTITUTO DE INVESTIGACIONES BIOMEDICAS AUGUST PI I SUNYER (IDIBAPS);
Fil: Reig, R.. INSTITUTO DE INVESTIGACIONES BIOMEDICAS AUGUST PI I SUNYER (IDIBAPS);
Fil: Sanchez Vives, M. V.. INSTITUTO DE INVESTIGACIONES BIOMEDICAS AUGUST PI I SUNYER (IDIBAPS);