Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs

Autores
Ashkar, E.; Stevens, J. J.; Houssay, Bernardo Alberto
Año de publicación
1968
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Twelve dogs that ran well on a motor-driven treadmill were vagotomized and sympathectomized from TI-TT plus LB-L6 and subjected to either unilateral adrenalectomy and contralateral adrenal demedullation (W-A) or denervation of cranial mesenteric and common hepatic arteries (SN-MH). After recovery, cardiac output determinations (direct Fick) and continuous recording of mean aortic blood pressure, heart rate, and oxygen consumption were made at rest and during exercise at 7.5 km/hr- 10% gradient Heart rate increased from 113 to 126 beats/min in the medulloadrenalectomized dogs and from 98 to 147 beats/min in dogs with hepatomesenteric denervation. Mean blood pressure did not vary substantially with exercise in either series of animals, averaging at rest 89 mm Hg in dogs with adrenal medullectomy and 128 mm Hg in dogs with intact adrenals. The resting cardiac index was similar in both groups (2.61 liters/min per m2) and increased about 200 y0 during exercise in medulloadrenalectomized animals as compared with 330y0 in dogs with hepatomesenteric denervation. During exercise, energy cost was essentially similar although peripheral resistance decreased about 75y0 in both groups.
copia
Fil: Ashkar, E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Stevens, J. J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
papel
TIBYME
Unidad documental simple
Materia
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
EL INVESTIGADOR
AUTONOMIC DENERVATION
HEART DENERVATION AND EXERCISES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123513
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123513
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogsAshkar, E.Stevens, J. J.Houssay, Bernardo AlbertoHOUSSAY, BERNARDO ALBERTOHOUSSAY EL INVESTIGADORPUBLICACIONES CIENTIFICASPUBLICACIONESEL INVESTIGADORAUTONOMIC DENERVATIONHEART DENERVATION AND EXERCISEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Twelve dogs that ran well on a motor-driven treadmill were vagotomized and sympathectomized from TI-TT plus LB-L6 and subjected to either unilateral adrenalectomy and contralateral adrenal demedullation (W-A) or denervation of cranial mesenteric and common hepatic arteries (SN-MH). After recovery, cardiac output determinations (direct Fick) and continuous recording of mean aortic blood pressure, heart rate, and oxygen consumption were made at rest and during exercise at 7.5 km/hr- 10% gradient Heart rate increased from 113 to 126 beats/min in the medulloadrenalectomized dogs and from 98 to 147 beats/min in dogs with hepatomesenteric denervation. Mean blood pressure did not vary substantially with exercise in either series of animals, averaging at rest 89 mm Hg in dogs with adrenal medullectomy and 128 mm Hg in dogs with intact adrenals. The resting cardiac index was similar in both groups (2.61 liters/min per m2) and increased about 200 y0 during exercise in medulloadrenalectomized animals as compared with 330y0 in dogs with hepatomesenteric denervation. During exercise, energy cost was essentially similar although peripheral resistance decreased about 75y0 in both groups.copiaFil: Ashkar, E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Stevens, J. J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinapapelTIBYMEUnidad documental simpleAmerican Physiological Society1968info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainEscalaGrisNoapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123513Ashkar, E.; Stevens, J. J.; Houssay, Bernardo Alberto; Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs; American Physiological Society; American Journal of Physiology; 214; 1; 1968; 22-270002-9513enginfo:eu-repo/semantics/altIdentifier/doi/10.1152/ajplegacy.1968.214.1.22info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/abs/10.1152/ajplegacy.1968.214.1.22Ciudad de Buenos AiresFundacion Williams.Fundación de Instituto de Biología y Medicina ExperimentalConsejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y LeloirIBYMEAR02675_ac3_DERinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T12:47:01Zoai:ri.conicet.gov.ar:11336/123513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 12:47:01.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
title Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
spellingShingle Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
Ashkar, E.
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
EL INVESTIGADOR
AUTONOMIC DENERVATION
HEART DENERVATION AND EXERCISES
title_short Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
title_full Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
title_fullStr Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
title_full_unstemmed Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
title_sort Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs
dc.creator.none.fl_str_mv Ashkar, E.
Stevens, J. J.
Houssay, Bernardo Alberto
author Ashkar, E.
author_facet Ashkar, E.
Stevens, J. J.
Houssay, Bernardo Alberto
author_role author
author2 Stevens, J. J.
Houssay, Bernardo Alberto
author2_role author
author
dc.subject.none.fl_str_mv HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
EL INVESTIGADOR
AUTONOMIC DENERVATION
HEART DENERVATION AND EXERCISES
topic HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
EL INVESTIGADOR
AUTONOMIC DENERVATION
HEART DENERVATION AND EXERCISES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Twelve dogs that ran well on a motor-driven treadmill were vagotomized and sympathectomized from TI-TT plus LB-L6 and subjected to either unilateral adrenalectomy and contralateral adrenal demedullation (W-A) or denervation of cranial mesenteric and common hepatic arteries (SN-MH). After recovery, cardiac output determinations (direct Fick) and continuous recording of mean aortic blood pressure, heart rate, and oxygen consumption were made at rest and during exercise at 7.5 km/hr- 10% gradient Heart rate increased from 113 to 126 beats/min in the medulloadrenalectomized dogs and from 98 to 147 beats/min in dogs with hepatomesenteric denervation. Mean blood pressure did not vary substantially with exercise in either series of animals, averaging at rest 89 mm Hg in dogs with adrenal medullectomy and 128 mm Hg in dogs with intact adrenals. The resting cardiac index was similar in both groups (2.61 liters/min per m2) and increased about 200 y0 during exercise in medulloadrenalectomized animals as compared with 330y0 in dogs with hepatomesenteric denervation. During exercise, energy cost was essentially similar although peripheral resistance decreased about 75y0 in both groups.
copia
Fil: Ashkar, E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Stevens, J. J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
papel
TIBYME
Unidad documental simple
description Twelve dogs that ran well on a motor-driven treadmill were vagotomized and sympathectomized from TI-TT plus LB-L6 and subjected to either unilateral adrenalectomy and contralateral adrenal demedullation (W-A) or denervation of cranial mesenteric and common hepatic arteries (SN-MH). After recovery, cardiac output determinations (direct Fick) and continuous recording of mean aortic blood pressure, heart rate, and oxygen consumption were made at rest and during exercise at 7.5 km/hr- 10% gradient Heart rate increased from 113 to 126 beats/min in the medulloadrenalectomized dogs and from 98 to 147 beats/min in dogs with hepatomesenteric denervation. Mean blood pressure did not vary substantially with exercise in either series of animals, averaging at rest 89 mm Hg in dogs with adrenal medullectomy and 128 mm Hg in dogs with intact adrenals. The resting cardiac index was similar in both groups (2.61 liters/min per m2) and increased about 200 y0 during exercise in medulloadrenalectomized animals as compared with 330y0 in dogs with hepatomesenteric denervation. During exercise, energy cost was essentially similar although peripheral resistance decreased about 75y0 in both groups.
publishDate 1968
dc.date.none.fl_str_mv 1968
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123513
Ashkar, E.; Stevens, J. J.; Houssay, Bernardo Alberto; Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs; American Physiological Society; American Journal of Physiology; 214; 1; 1968; 22-27
0002-9513
url http://hdl.handle.net/11336/123513
identifier_str_mv Ashkar, E.; Stevens, J. J.; Houssay, Bernardo Alberto; Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs; American Physiological Society; American Journal of Physiology; 214; 1; 1968; 22-27
0002-9513
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1152/ajplegacy.1968.214.1.22
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/abs/10.1152/ajplegacy.1968.214.1.22
Ciudad de Buenos Aires
Fundacion Williams.
Fundación de Instituto de Biología y Medicina Experimental
Consejo Nacional de Investigaciones Científicas y Técnicas
Proyecto Houssay y Leloir
IBYME
AR02675_ac3_DER
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv text/plain
EscalaGris
No
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1853775012428775424
score 13.25844

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