Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode

Autores
Torriero, Angel Alberto Jesus; Tonn, Carlos Eugenio; Sereno, Leonides Edmundo; Raba, Julio
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam at the glassy carbon electrode in 10% ACN + 90% 0.2 M Britton-Robinson Buffer is presented. Cyclic voltammetry, controlled potential electrolysis and spectroscopic techniques were used to obtain information about the reaction mechanism and product identification. After exhaustive electrolysis, the extraction followed by chromatographic separation of the reaction products gave the oxidized compounds. Using UV-Vis, GC-MS, 1H and 13C NMR techniques as well as the results of our preceding electrochemical investigation, 2-{[(carboxycarbonyl)(methyl)amino]sulfonyl}benzoic acid and 2-aminopyridine were identified. To account for the formation of these products, a detailed interpretation of the mechanism of the electrooxidation of piroxicam in acidic-buffered media was presented.
Fil: Torriero, Angel Alberto Jesus. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
Fil: Sereno, Leonides Edmundo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Raba, Julio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
CONTROLLED POTENTIAL ELECTROLYSIS
CYCLIC VOLTAMMETRY
ELECTROOXIDATION
PIROXICAM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97472
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/97472
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrodeTorriero, Angel Alberto JesusTonn, Carlos EugenioSereno, Leonides EdmundoRaba, JulioCONTROLLED POTENTIAL ELECTROLYSISCYCLIC VOLTAMMETRYELECTROOXIDATIONPIROXICAMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam at the glassy carbon electrode in 10% ACN + 90% 0.2 M Britton-Robinson Buffer is presented. Cyclic voltammetry, controlled potential electrolysis and spectroscopic techniques were used to obtain information about the reaction mechanism and product identification. After exhaustive electrolysis, the extraction followed by chromatographic separation of the reaction products gave the oxidized compounds. Using UV-Vis, GC-MS, 1H and 13C NMR techniques as well as the results of our preceding electrochemical investigation, 2-{[(carboxycarbonyl)(methyl)amino]sulfonyl}benzoic acid and 2-aminopyridine were identified. To account for the formation of these products, a detailed interpretation of the mechanism of the electrooxidation of piroxicam in acidic-buffered media was presented.Fil: Torriero, Angel Alberto Jesus. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; ArgentinaFil: Sereno, Leonides Edmundo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Raba, Julio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaElsevier Science Sa2006-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97472Torriero, Angel Alberto Jesus; Tonn, Carlos Eugenio; Sereno, Leonides Edmundo; Raba, Julio; Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode; Elsevier Science Sa; Journal of Electroanalytical Chemistry; 588; 2; 3-2006; 218-2250022-07281572-6657CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022072806000064info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jelechem.2005.12.023info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:22:47Zoai:ri.conicet.gov.ar:11336/97472instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:22:48.245CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
title Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
spellingShingle Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
Torriero, Angel Alberto Jesus
CONTROLLED POTENTIAL ELECTROLYSIS
CYCLIC VOLTAMMETRY
ELECTROOXIDATION
PIROXICAM
title_short Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
title_full Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
title_fullStr Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
title_full_unstemmed Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
title_sort Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
dc.creator.none.fl_str_mv Torriero, Angel Alberto Jesus
Tonn, Carlos Eugenio
Sereno, Leonides Edmundo
Raba, Julio
author Torriero, Angel Alberto Jesus
author_facet Torriero, Angel Alberto Jesus
Tonn, Carlos Eugenio
Sereno, Leonides Edmundo
Raba, Julio
author_role author
author2 Tonn, Carlos Eugenio
Sereno, Leonides Edmundo
Raba, Julio
author2_role author
author
author
dc.subject.none.fl_str_mv CONTROLLED POTENTIAL ELECTROLYSIS
CYCLIC VOLTAMMETRY
ELECTROOXIDATION
PIROXICAM
topic CONTROLLED POTENTIAL ELECTROLYSIS
CYCLIC VOLTAMMETRY
ELECTROOXIDATION
PIROXICAM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam at the glassy carbon electrode in 10% ACN + 90% 0.2 M Britton-Robinson Buffer is presented. Cyclic voltammetry, controlled potential electrolysis and spectroscopic techniques were used to obtain information about the reaction mechanism and product identification. After exhaustive electrolysis, the extraction followed by chromatographic separation of the reaction products gave the oxidized compounds. Using UV-Vis, GC-MS, 1H and 13C NMR techniques as well as the results of our preceding electrochemical investigation, 2-{[(carboxycarbonyl)(methyl)amino]sulfonyl}benzoic acid and 2-aminopyridine were identified. To account for the formation of these products, a detailed interpretation of the mechanism of the electrooxidation of piroxicam in acidic-buffered media was presented.
Fil: Torriero, Angel Alberto Jesus. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
Fil: Sereno, Leonides Edmundo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Raba, Julio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam at the glassy carbon electrode in 10% ACN + 90% 0.2 M Britton-Robinson Buffer is presented. Cyclic voltammetry, controlled potential electrolysis and spectroscopic techniques were used to obtain information about the reaction mechanism and product identification. After exhaustive electrolysis, the extraction followed by chromatographic separation of the reaction products gave the oxidized compounds. Using UV-Vis, GC-MS, 1H and 13C NMR techniques as well as the results of our preceding electrochemical investigation, 2-{[(carboxycarbonyl)(methyl)amino]sulfonyl}benzoic acid and 2-aminopyridine were identified. To account for the formation of these products, a detailed interpretation of the mechanism of the electrooxidation of piroxicam in acidic-buffered media was presented.
publishDate 2006
dc.date.none.fl_str_mv 2006-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97472
Torriero, Angel Alberto Jesus; Tonn, Carlos Eugenio; Sereno, Leonides Edmundo; Raba, Julio; Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode; Elsevier Science Sa; Journal of Electroanalytical Chemistry; 588; 2; 3-2006; 218-225
0022-0728
1572-6657
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97472
identifier_str_mv Torriero, Angel Alberto Jesus; Tonn, Carlos Eugenio; Sereno, Leonides Edmundo; Raba, Julio; Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode; Elsevier Science Sa; Journal of Electroanalytical Chemistry; 588; 2; 3-2006; 218-225
0022-0728
1572-6657
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022072806000064
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jelechem.2005.12.023
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781749764292608
score 12.928904

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