Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain

Autores
Errasti, María Eugenia; Caffini, Nestor Oscar; Pelzer, Lilian Eugenia; Rotelli, Alejandra Ester
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Some plant proteases (e. g., papain, bromelain, ficin) have been used as anti-inflammatory agents for some years, and especially bromelain is still being used as alternative and/or complementary therapy to glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. Bromelain is an extract rich in cysteine endopeptidases obtained from Ananas comosus. In this study the anti-inflammatory action of a partially purified extract of Bromelia hieronymi fruits, whose main components are cysteine endopeptidases, is presented. Different doses of a partially purified extract of B. hieronymi were assayed on carrageenan-induced and serotonine-induced rat paw edema, as well as in cotton pellet granuloma model. Doses with equal proteolytic activity of the partially purified extract and bromelain showed significantly similar anti-inflammatory responses. Treatment of the partially purified extract and bromelain with E-64 provoked loss of anti-inflammatory activity on carrageenan-induced paw edema, a fact which is consistent with the hypothesis that the proteolytic activity would be responsible for the anti-inflammatory action.
Fil: Errasti, María Eugenia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caffini, Nestor Oscar. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina
Fil: Pelzer, Lilian Eugenia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Materia
Bromelia Hieronymi
Bromeliaceae
Bromelain
Anti-Inflammatory
Plant Proteases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21938
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Anti-inflammatory Activity of Bromelia hieronymi: Comparison with BromelainErrasti, María EugeniaCaffini, Nestor OscarPelzer, Lilian EugeniaRotelli, Alejandra EsterBromelia HieronymiBromeliaceaeBromelainAnti-InflammatoryPlant Proteaseshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Some plant proteases (e. g., papain, bromelain, ficin) have been used as anti-inflammatory agents for some years, and especially bromelain is still being used as alternative and/or complementary therapy to glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. Bromelain is an extract rich in cysteine endopeptidases obtained from Ananas comosus. In this study the anti-inflammatory action of a partially purified extract of Bromelia hieronymi fruits, whose main components are cysteine endopeptidases, is presented. Different doses of a partially purified extract of B. hieronymi were assayed on carrageenan-induced and serotonine-induced rat paw edema, as well as in cotton pellet granuloma model. Doses with equal proteolytic activity of the partially purified extract and bromelain showed significantly similar anti-inflammatory responses. Treatment of the partially purified extract and bromelain with E-64 provoked loss of anti-inflammatory activity on carrageenan-induced paw edema, a fact which is consistent with the hypothesis that the proteolytic activity would be responsible for the anti-inflammatory action.Fil: Errasti, María Eugenia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caffini, Nestor Oscar. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; ArgentinaFil: Pelzer, Lilian Eugenia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaGeorg Thieme Verlag Kg2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21938Errasti, María Eugenia; Caffini, Nestor Oscar; Pelzer, Lilian Eugenia; Rotelli, Alejandra Ester; Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain; Georg Thieme Verlag Kg; Planta Medica; 79; 3-4; 1-2013; 207-2130032-0943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1055/s-0032-1328201info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1328201info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:39Zoai:ri.conicet.gov.ar:11336/21938instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:39.78CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
title Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
spellingShingle Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
Errasti, María Eugenia
Bromelia Hieronymi
Bromeliaceae
Bromelain
Anti-Inflammatory
Plant Proteases
title_short Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
title_full Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
title_fullStr Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
title_full_unstemmed Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
title_sort Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain
dc.creator.none.fl_str_mv Errasti, María Eugenia
Caffini, Nestor Oscar
Pelzer, Lilian Eugenia
Rotelli, Alejandra Ester
author Errasti, María Eugenia
author_facet Errasti, María Eugenia
Caffini, Nestor Oscar
Pelzer, Lilian Eugenia
Rotelli, Alejandra Ester
author_role author
author2 Caffini, Nestor Oscar
Pelzer, Lilian Eugenia
Rotelli, Alejandra Ester
author2_role author
author
author
dc.subject.none.fl_str_mv Bromelia Hieronymi
Bromeliaceae
Bromelain
Anti-Inflammatory
Plant Proteases
topic Bromelia Hieronymi
Bromeliaceae
Bromelain
Anti-Inflammatory
Plant Proteases
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Some plant proteases (e. g., papain, bromelain, ficin) have been used as anti-inflammatory agents for some years, and especially bromelain is still being used as alternative and/or complementary therapy to glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. Bromelain is an extract rich in cysteine endopeptidases obtained from Ananas comosus. In this study the anti-inflammatory action of a partially purified extract of Bromelia hieronymi fruits, whose main components are cysteine endopeptidases, is presented. Different doses of a partially purified extract of B. hieronymi were assayed on carrageenan-induced and serotonine-induced rat paw edema, as well as in cotton pellet granuloma model. Doses with equal proteolytic activity of the partially purified extract and bromelain showed significantly similar anti-inflammatory responses. Treatment of the partially purified extract and bromelain with E-64 provoked loss of anti-inflammatory activity on carrageenan-induced paw edema, a fact which is consistent with the hypothesis that the proteolytic activity would be responsible for the anti-inflammatory action.
Fil: Errasti, María Eugenia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caffini, Nestor Oscar. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigacion de Proteinas Vegetales; Argentina
Fil: Pelzer, Lilian Eugenia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
description Some plant proteases (e. g., papain, bromelain, ficin) have been used as anti-inflammatory agents for some years, and especially bromelain is still being used as alternative and/or complementary therapy to glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. Bromelain is an extract rich in cysteine endopeptidases obtained from Ananas comosus. In this study the anti-inflammatory action of a partially purified extract of Bromelia hieronymi fruits, whose main components are cysteine endopeptidases, is presented. Different doses of a partially purified extract of B. hieronymi were assayed on carrageenan-induced and serotonine-induced rat paw edema, as well as in cotton pellet granuloma model. Doses with equal proteolytic activity of the partially purified extract and bromelain showed significantly similar anti-inflammatory responses. Treatment of the partially purified extract and bromelain with E-64 provoked loss of anti-inflammatory activity on carrageenan-induced paw edema, a fact which is consistent with the hypothesis that the proteolytic activity would be responsible for the anti-inflammatory action.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21938
Errasti, María Eugenia; Caffini, Nestor Oscar; Pelzer, Lilian Eugenia; Rotelli, Alejandra Ester; Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain; Georg Thieme Verlag Kg; Planta Medica; 79; 3-4; 1-2013; 207-213
0032-0943
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21938
identifier_str_mv Errasti, María Eugenia; Caffini, Nestor Oscar; Pelzer, Lilian Eugenia; Rotelli, Alejandra Ester; Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain; Georg Thieme Verlag Kg; Planta Medica; 79; 3-4; 1-2013; 207-213
0032-0943
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0032-1328201
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1328201
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268809887481856
score 13.13397

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