Exploring Boron Neutron Capture Therapy for non-small cell lung cancer

Autores
Farías, Rubén Oscar; Bortolussi, Silva; Bonvicini Menéndez, Pablo Federico; González, Sara Josefina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Boron Neutron Capture Therapy (BNCT) is a radiotherapy that combines biological targeting and high LET radiation. It consists in the enrichment of tumour with 10B and in the successive irradiation of the target with low energy neutrons producing charged particles that mainly cause non-repairable damages to the cells.The feasibility to treat Non Small Cells Lung Cancer (NSCLC) with BNCT was explored. This paper proposes a new approach to determine treatment plans, introducing the possibility to choose the irradiation start and duration to maximize the tumour dose. A Tumour Control Probability (TCP) suited for lung BNCT as well as other high dose radiotherapy schemes was also introduced.Treatment plans were evaluated in localized and disseminated lung tumours. Semi-ideal and real energy spectra beams were employed to assess the best energy range and the performance of non-tailored neutron sources for lung tumour treatments.The optimal neutron energy is within [500eV-3keV], lower than the 10keV suggested for the treatment of deep-seated tumours in the brain. TCPs higher than 0.6 and up to 0.95 are obtained for all cases.Conclusions drawn from [Suzuki etal., Int Canc Conf J 1 (4) (2012) 235-238] supporting the feasibility of BNCT for shallow lung tumours are confirmed, however discussions favouring the treatment of deeper lesions and disseminated disease are also opened. Since BNCT gives the possibility to deliver a safe and potentially effective treatment for NSCLC, it can be considered a suitable alternative for patients with few or no treatment options.
Fil: Farías, Rubén Oscar. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bortolussi, Silva. Università degli Studi di Pavia; Italia
Fil: Bonvicini Menéndez, Pablo Federico. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
Fil: González, Sara Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina
Materia
Bnct
Lung Tumours
Mcnp
Tumour Control Probability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38401
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38401
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Exploring Boron Neutron Capture Therapy for non-small cell lung cancerFarías, Rubén OscarBortolussi, SilvaBonvicini Menéndez, Pablo FedericoGonzález, Sara JosefinaBnctLung TumoursMcnpTumour Control Probabilityhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Boron Neutron Capture Therapy (BNCT) is a radiotherapy that combines biological targeting and high LET radiation. It consists in the enrichment of tumour with 10B and in the successive irradiation of the target with low energy neutrons producing charged particles that mainly cause non-repairable damages to the cells.The feasibility to treat Non Small Cells Lung Cancer (NSCLC) with BNCT was explored. This paper proposes a new approach to determine treatment plans, introducing the possibility to choose the irradiation start and duration to maximize the tumour dose. A Tumour Control Probability (TCP) suited for lung BNCT as well as other high dose radiotherapy schemes was also introduced.Treatment plans were evaluated in localized and disseminated lung tumours. Semi-ideal and real energy spectra beams were employed to assess the best energy range and the performance of non-tailored neutron sources for lung tumour treatments.The optimal neutron energy is within [500eV-3keV], lower than the 10keV suggested for the treatment of deep-seated tumours in the brain. TCPs higher than 0.6 and up to 0.95 are obtained for all cases.Conclusions drawn from [Suzuki etal., Int Canc Conf J 1 (4) (2012) 235-238] supporting the feasibility of BNCT for shallow lung tumours are confirmed, however discussions favouring the treatment of deeper lesions and disseminated disease are also opened. Since BNCT gives the possibility to deliver a safe and potentially effective treatment for NSCLC, it can be considered a suitable alternative for patients with few or no treatment options.Fil: Farías, Rubén Oscar. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bortolussi, Silva. Università degli Studi di Pavia; ItaliaFil: Bonvicini Menéndez, Pablo Federico. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; ArgentinaFil: González, Sara Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; ArgentinaIstituti Editoriali e Poligrafici Internazionali2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38401Farías, Rubén Oscar; Bortolussi, Silva; Bonvicini Menéndez, Pablo Federico; González, Sara Josefina; Exploring Boron Neutron Capture Therapy for non-small cell lung cancer; Istituti Editoriali e Poligrafici Internazionali; Physica Medica; 30; 8; 12-2014; 888-8971120-1797CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1120179714005067info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmp.2014.07.342info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:40Zoai:ri.conicet.gov.ar:11336/38401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:40.748CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
title Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
spellingShingle Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
Farías, Rubén Oscar
Bnct
Lung Tumours
Mcnp
Tumour Control Probability
title_short Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
title_full Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
title_fullStr Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
title_full_unstemmed Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
title_sort Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
dc.creator.none.fl_str_mv Farías, Rubén Oscar
Bortolussi, Silva
Bonvicini Menéndez, Pablo Federico
González, Sara Josefina
author Farías, Rubén Oscar
author_facet Farías, Rubén Oscar
Bortolussi, Silva
Bonvicini Menéndez, Pablo Federico
González, Sara Josefina
author_role author
author2 Bortolussi, Silva
Bonvicini Menéndez, Pablo Federico
González, Sara Josefina
author2_role author
author
author
dc.subject.none.fl_str_mv Bnct
Lung Tumours
Mcnp
Tumour Control Probability
topic Bnct
Lung Tumours
Mcnp
Tumour Control Probability
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Boron Neutron Capture Therapy (BNCT) is a radiotherapy that combines biological targeting and high LET radiation. It consists in the enrichment of tumour with 10B and in the successive irradiation of the target with low energy neutrons producing charged particles that mainly cause non-repairable damages to the cells.The feasibility to treat Non Small Cells Lung Cancer (NSCLC) with BNCT was explored. This paper proposes a new approach to determine treatment plans, introducing the possibility to choose the irradiation start and duration to maximize the tumour dose. A Tumour Control Probability (TCP) suited for lung BNCT as well as other high dose radiotherapy schemes was also introduced.Treatment plans were evaluated in localized and disseminated lung tumours. Semi-ideal and real energy spectra beams were employed to assess the best energy range and the performance of non-tailored neutron sources for lung tumour treatments.The optimal neutron energy is within [500eV-3keV], lower than the 10keV suggested for the treatment of deep-seated tumours in the brain. TCPs higher than 0.6 and up to 0.95 are obtained for all cases.Conclusions drawn from [Suzuki etal., Int Canc Conf J 1 (4) (2012) 235-238] supporting the feasibility of BNCT for shallow lung tumours are confirmed, however discussions favouring the treatment of deeper lesions and disseminated disease are also opened. Since BNCT gives the possibility to deliver a safe and potentially effective treatment for NSCLC, it can be considered a suitable alternative for patients with few or no treatment options.
Fil: Farías, Rubén Oscar. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bortolussi, Silva. Università degli Studi di Pavia; Italia
Fil: Bonvicini Menéndez, Pablo Federico. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
Fil: González, Sara Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina
description Boron Neutron Capture Therapy (BNCT) is a radiotherapy that combines biological targeting and high LET radiation. It consists in the enrichment of tumour with 10B and in the successive irradiation of the target with low energy neutrons producing charged particles that mainly cause non-repairable damages to the cells.The feasibility to treat Non Small Cells Lung Cancer (NSCLC) with BNCT was explored. This paper proposes a new approach to determine treatment plans, introducing the possibility to choose the irradiation start and duration to maximize the tumour dose. A Tumour Control Probability (TCP) suited for lung BNCT as well as other high dose radiotherapy schemes was also introduced.Treatment plans were evaluated in localized and disseminated lung tumours. Semi-ideal and real energy spectra beams were employed to assess the best energy range and the performance of non-tailored neutron sources for lung tumour treatments.The optimal neutron energy is within [500eV-3keV], lower than the 10keV suggested for the treatment of deep-seated tumours in the brain. TCPs higher than 0.6 and up to 0.95 are obtained for all cases.Conclusions drawn from [Suzuki etal., Int Canc Conf J 1 (4) (2012) 235-238] supporting the feasibility of BNCT for shallow lung tumours are confirmed, however discussions favouring the treatment of deeper lesions and disseminated disease are also opened. Since BNCT gives the possibility to deliver a safe and potentially effective treatment for NSCLC, it can be considered a suitable alternative for patients with few or no treatment options.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38401
Farías, Rubén Oscar; Bortolussi, Silva; Bonvicini Menéndez, Pablo Federico; González, Sara Josefina; Exploring Boron Neutron Capture Therapy for non-small cell lung cancer; Istituti Editoriali e Poligrafici Internazionali; Physica Medica; 30; 8; 12-2014; 888-897
1120-1797
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38401
identifier_str_mv Farías, Rubén Oscar; Bortolussi, Silva; Bonvicini Menéndez, Pablo Federico; González, Sara Josefina; Exploring Boron Neutron Capture Therapy for non-small cell lung cancer; Istituti Editoriali e Poligrafici Internazionali; Physica Medica; 30; 8; 12-2014; 888-897
1120-1797
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1120179714005067
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmp.2014.07.342
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Istituti Editoriali e Poligrafici Internazionali
publisher.none.fl_str_mv Istituti Editoriali e Poligrafici Internazionali
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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