Delay model of the circadian pacemaker

Autores
Lema, Martín A.; Golombek, Diego Andrés; Echave, Julián
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We present a simple and realistic model of the circadian pacemaker that can be interpreted in molecular terms. The model, which consists of a single time-delay differential equation, simulates the expression of a generic clock protein that inhibits its own expression through a feedback mechanism. Despite its simplicity, this model fulfils most of the necessary characteristics of a realistic representation of natural circadian clocks: robust and stable oscillations with circadian free-running periods, typical phase response curves and entrainment to environmental zeitgebers. The present model reduces the molecular mechanism necessary to sustain stable oscillations to its bare bones, suggesting that the essential factor is the time-delayed negative feedback of the oscillating protein on its own expression. (C) 2000 Academic Press.
Fil: Lema, Martín A.. Universidad Nacional de Quilmes; Argentina
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Echave, Julián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Materia
Ccircadian Clock
Delay Model
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71610
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/71610
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Delay model of the circadian pacemakerLema, Martín A.Golombek, Diego AndrésEchave, JuliánCcircadian ClockDelay Modelhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We present a simple and realistic model of the circadian pacemaker that can be interpreted in molecular terms. The model, which consists of a single time-delay differential equation, simulates the expression of a generic clock protein that inhibits its own expression through a feedback mechanism. Despite its simplicity, this model fulfils most of the necessary characteristics of a realistic representation of natural circadian clocks: robust and stable oscillations with circadian free-running periods, typical phase response curves and entrainment to environmental zeitgebers. The present model reduces the molecular mechanism necessary to sustain stable oscillations to its bare bones, suggesting that the essential factor is the time-delayed negative feedback of the oscillating protein on its own expression. (C) 2000 Academic Press.Fil: Lema, Martín A.. Universidad Nacional de Quilmes; ArgentinaFil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Echave, Julián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2000-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71610Lema, Martín A.; Golombek, Diego Andrés; Echave, Julián; Delay model of the circadian pacemaker; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 204; 4; 6-2000; 565-5730022-5193CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1006/jtbi.2000.2038info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022519300920381info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:42Zoai:ri.conicet.gov.ar:11336/71610instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:43.114CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Delay model of the circadian pacemaker
title Delay model of the circadian pacemaker
spellingShingle Delay model of the circadian pacemaker
Lema, Martín A.
Ccircadian Clock
Delay Model
title_short Delay model of the circadian pacemaker
title_full Delay model of the circadian pacemaker
title_fullStr Delay model of the circadian pacemaker
title_full_unstemmed Delay model of the circadian pacemaker
title_sort Delay model of the circadian pacemaker
dc.creator.none.fl_str_mv Lema, Martín A.
Golombek, Diego Andrés
Echave, Julián
author Lema, Martín A.
author_facet Lema, Martín A.
Golombek, Diego Andrés
Echave, Julián
author_role author
author2 Golombek, Diego Andrés
Echave, Julián
author2_role author
author
dc.subject.none.fl_str_mv Ccircadian Clock
Delay Model
topic Ccircadian Clock
Delay Model
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We present a simple and realistic model of the circadian pacemaker that can be interpreted in molecular terms. The model, which consists of a single time-delay differential equation, simulates the expression of a generic clock protein that inhibits its own expression through a feedback mechanism. Despite its simplicity, this model fulfils most of the necessary characteristics of a realistic representation of natural circadian clocks: robust and stable oscillations with circadian free-running periods, typical phase response curves and entrainment to environmental zeitgebers. The present model reduces the molecular mechanism necessary to sustain stable oscillations to its bare bones, suggesting that the essential factor is the time-delayed negative feedback of the oscillating protein on its own expression. (C) 2000 Academic Press.
Fil: Lema, Martín A.. Universidad Nacional de Quilmes; Argentina
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Echave, Julián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
description We present a simple and realistic model of the circadian pacemaker that can be interpreted in molecular terms. The model, which consists of a single time-delay differential equation, simulates the expression of a generic clock protein that inhibits its own expression through a feedback mechanism. Despite its simplicity, this model fulfils most of the necessary characteristics of a realistic representation of natural circadian clocks: robust and stable oscillations with circadian free-running periods, typical phase response curves and entrainment to environmental zeitgebers. The present model reduces the molecular mechanism necessary to sustain stable oscillations to its bare bones, suggesting that the essential factor is the time-delayed negative feedback of the oscillating protein on its own expression. (C) 2000 Academic Press.
publishDate 2000
dc.date.none.fl_str_mv 2000-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71610
Lema, Martín A.; Golombek, Diego Andrés; Echave, Julián; Delay model of the circadian pacemaker; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 204; 4; 6-2000; 565-573
0022-5193
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71610
identifier_str_mv Lema, Martín A.; Golombek, Diego Andrés; Echave, Julián; Delay model of the circadian pacemaker; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 204; 4; 6-2000; 565-573
0022-5193
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1006/jtbi.2000.2038
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022519300920381
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613957607751680
score 13.070432

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