Histaminergic systems of the limbic complex on learning and motivation

Autores
Alvarez, Edgardo O.; Ruarte, Marcela B.; Banzan, Arturo Martin
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic tone anticipating an electric shock was used. As a model of motivation, an elevated asymmetric plus-maze with arms differing in the presence or absence of walls (APM) was used. All rats were implanted with microinjection cannulae into the ventral, dorsal hippocampus or the nucleus accumbens. Animals were stimulated with histamine, with or without histamine receptor antagonists 5 min before training trials in memory or exploration tests in the APM. Results show that histamine in ventral hippocampus inhibits evocation, impairing the efficiency of learning (37.5 ± 6.5 vs. 75 ± 5.2% of accumulated conditioning responses; histamine vs. saline, P < 0.01). This inhibitory action was blocked by pyrilamine (H1-histamine receptor antagonist) but not by ranitidine (H2-histamine receptor antagonist). In dorsal hippocampus no significant inhibitory effect due to histamine stimulation was observed. In the APM, histamine in the nucleus accumbens increased exploration of the fear-inducing arms (45 ± 12 vs. 16 ± 8 counts per 5 min; histamine vs. saline, P < 0.01) and also increased the emotionality index. These effects were blocked by both histamine receptor antagonists. In conclusion, data suggest a modulating role for histamine in learning and motivation/emotionality processes in the rat brain.
Fil: Alvarez, Edgardo O.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Ruarte, Marcela B.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
HISTAMINE
LEARNING
MOTIVATION
NUCLEUS ACCUMBENS
VENTRAL HIPPOCAMPUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127535
Acceder
id CONICETDig_6a0ba7922197c47db83ae69fb3b8c7e2
oai_identifier_str oai:ri.conicet.gov.ar:11336/127535
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histaminergic systems of the limbic complex on learning and motivationAlvarez, Edgardo O.Ruarte, Marcela B.Banzan, Arturo MartinHISTAMINELEARNINGMOTIVATIONNUCLEUS ACCUMBENSVENTRAL HIPPOCAMPUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic tone anticipating an electric shock was used. As a model of motivation, an elevated asymmetric plus-maze with arms differing in the presence or absence of walls (APM) was used. All rats were implanted with microinjection cannulae into the ventral, dorsal hippocampus or the nucleus accumbens. Animals were stimulated with histamine, with or without histamine receptor antagonists 5 min before training trials in memory or exploration tests in the APM. Results show that histamine in ventral hippocampus inhibits evocation, impairing the efficiency of learning (37.5 ± 6.5 vs. 75 ± 5.2% of accumulated conditioning responses; histamine vs. saline, P < 0.01). This inhibitory action was blocked by pyrilamine (H1-histamine receptor antagonist) but not by ranitidine (H2-histamine receptor antagonist). In dorsal hippocampus no significant inhibitory effect due to histamine stimulation was observed. In the APM, histamine in the nucleus accumbens increased exploration of the fear-inducing arms (45 ± 12 vs. 16 ± 8 counts per 5 min; histamine vs. saline, P < 0.01) and also increased the emotionality index. These effects were blocked by both histamine receptor antagonists. In conclusion, data suggest a modulating role for histamine in learning and motivation/emotionality processes in the rat brain.Fil: Alvarez, Edgardo O.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Ruarte, Marcela B.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaElsevier Science2001-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/127535Alvarez, Edgardo O.; Ruarte, Marcela B.; Banzan, Arturo Martin; Histaminergic systems of the limbic complex on learning and motivation; Elsevier Science; Behavioural Brain Research; 124; 2; 10-2001; 195-2020166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0166-4328(01)00213-3info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0166432801002133info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:43:08Zoai:ri.conicet.gov.ar:11336/127535instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:43:08.708CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histaminergic systems of the limbic complex on learning and motivation
title Histaminergic systems of the limbic complex on learning and motivation
spellingShingle Histaminergic systems of the limbic complex on learning and motivation
Alvarez, Edgardo O.
HISTAMINE
LEARNING
MOTIVATION
NUCLEUS ACCUMBENS
VENTRAL HIPPOCAMPUS
title_short Histaminergic systems of the limbic complex on learning and motivation
title_full Histaminergic systems of the limbic complex on learning and motivation
title_fullStr Histaminergic systems of the limbic complex on learning and motivation
title_full_unstemmed Histaminergic systems of the limbic complex on learning and motivation
title_sort Histaminergic systems of the limbic complex on learning and motivation
dc.creator.none.fl_str_mv Alvarez, Edgardo O.
Ruarte, Marcela B.
Banzan, Arturo Martin
author Alvarez, Edgardo O.
author_facet Alvarez, Edgardo O.
Ruarte, Marcela B.
Banzan, Arturo Martin
author_role author
author2 Ruarte, Marcela B.
Banzan, Arturo Martin
author2_role author
author
dc.subject.none.fl_str_mv HISTAMINE
LEARNING
MOTIVATION
NUCLEUS ACCUMBENS
VENTRAL HIPPOCAMPUS
topic HISTAMINE
LEARNING
MOTIVATION
NUCLEUS ACCUMBENS
VENTRAL HIPPOCAMPUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic tone anticipating an electric shock was used. As a model of motivation, an elevated asymmetric plus-maze with arms differing in the presence or absence of walls (APM) was used. All rats were implanted with microinjection cannulae into the ventral, dorsal hippocampus or the nucleus accumbens. Animals were stimulated with histamine, with or without histamine receptor antagonists 5 min before training trials in memory or exploration tests in the APM. Results show that histamine in ventral hippocampus inhibits evocation, impairing the efficiency of learning (37.5 ± 6.5 vs. 75 ± 5.2% of accumulated conditioning responses; histamine vs. saline, P < 0.01). This inhibitory action was blocked by pyrilamine (H1-histamine receptor antagonist) but not by ranitidine (H2-histamine receptor antagonist). In dorsal hippocampus no significant inhibitory effect due to histamine stimulation was observed. In the APM, histamine in the nucleus accumbens increased exploration of the fear-inducing arms (45 ± 12 vs. 16 ± 8 counts per 5 min; histamine vs. saline, P < 0.01) and also increased the emotionality index. These effects were blocked by both histamine receptor antagonists. In conclusion, data suggest a modulating role for histamine in learning and motivation/emotionality processes in the rat brain.
Fil: Alvarez, Edgardo O.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Ruarte, Marcela B.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Banzan, Arturo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic tone anticipating an electric shock was used. As a model of motivation, an elevated asymmetric plus-maze with arms differing in the presence or absence of walls (APM) was used. All rats were implanted with microinjection cannulae into the ventral, dorsal hippocampus or the nucleus accumbens. Animals were stimulated with histamine, with or without histamine receptor antagonists 5 min before training trials in memory or exploration tests in the APM. Results show that histamine in ventral hippocampus inhibits evocation, impairing the efficiency of learning (37.5 ± 6.5 vs. 75 ± 5.2% of accumulated conditioning responses; histamine vs. saline, P < 0.01). This inhibitory action was blocked by pyrilamine (H1-histamine receptor antagonist) but not by ranitidine (H2-histamine receptor antagonist). In dorsal hippocampus no significant inhibitory effect due to histamine stimulation was observed. In the APM, histamine in the nucleus accumbens increased exploration of the fear-inducing arms (45 ± 12 vs. 16 ± 8 counts per 5 min; histamine vs. saline, P < 0.01) and also increased the emotionality index. These effects were blocked by both histamine receptor antagonists. In conclusion, data suggest a modulating role for histamine in learning and motivation/emotionality processes in the rat brain.
publishDate 2001
dc.date.none.fl_str_mv 2001-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127535
Alvarez, Edgardo O.; Ruarte, Marcela B.; Banzan, Arturo Martin; Histaminergic systems of the limbic complex on learning and motivation; Elsevier Science; Behavioural Brain Research; 124; 2; 10-2001; 195-202
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127535
identifier_str_mv Alvarez, Edgardo O.; Ruarte, Marcela B.; Banzan, Arturo Martin; Histaminergic systems of the limbic complex on learning and motivation; Elsevier Science; Behavioural Brain Research; 124; 2; 10-2001; 195-202
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/S0166-4328(01)00213-3
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0166432801002133
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082935956963328
score 13.22299

Publicaciones similares