Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
- Autores
- Gabrielsen, Mads; Rey Burusco, María Florencia; Griffiths, Kate; Roe, Andrew J.; Cooper, Alan; Smith, Brian O.; Kennedy, Malcolm W.; Córsico, Betina
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.
Instituto de Investigaciones Bioquímicas de La Plata - Materia
-
Ciencias Médicas
fatty acid- and retinol-binding proteins
Na-FAR-1
Necator americanus
parasitic nematodes - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/84080
Ver los metadatos del registro completo
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Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanusGabrielsen, MadsRey Burusco, María FlorenciaGriffiths, KateRoe, Andrew J.Cooper, AlanSmith, Brian O.Kennedy, Malcolm W.Córsico, BetinaCiencias Médicasfatty acid- and retinol-binding proteinsNa-FAR-1Necator americanusparasitic nematodesNa-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.Instituto de Investigaciones Bioquímicas de La Plata2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf835-838http://sedici.unlp.edu.ar/handle/10915/84080enginfo:eu-repo/semantics/altIdentifier/issn/1744-3091info:eu-repo/semantics/altIdentifier/doi/10.1107/S1744309112023597info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T16:56:52Zoai:sedici.unlp.edu.ar:10915/84080Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 16:56:53.129SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| title |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| spellingShingle |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus Gabrielsen, Mads Ciencias Médicas fatty acid- and retinol-binding proteins Na-FAR-1 Necator americanus parasitic nematodes |
| title_short |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| title_full |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| title_fullStr |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| title_full_unstemmed |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| title_sort |
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus |
| dc.creator.none.fl_str_mv |
Gabrielsen, Mads Rey Burusco, María Florencia Griffiths, Kate Roe, Andrew J. Cooper, Alan Smith, Brian O. Kennedy, Malcolm W. Córsico, Betina |
| author |
Gabrielsen, Mads |
| author_facet |
Gabrielsen, Mads Rey Burusco, María Florencia Griffiths, Kate Roe, Andrew J. Cooper, Alan Smith, Brian O. Kennedy, Malcolm W. Córsico, Betina |
| author_role |
author |
| author2 |
Rey Burusco, María Florencia Griffiths, Kate Roe, Andrew J. Cooper, Alan Smith, Brian O. Kennedy, Malcolm W. Córsico, Betina |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas fatty acid- and retinol-binding proteins Na-FAR-1 Necator americanus parasitic nematodes |
| topic |
Ciencias Médicas fatty acid- and retinol-binding proteins Na-FAR-1 Necator americanus parasitic nematodes |
| dc.description.none.fl_txt_mv |
Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning. Instituto de Investigaciones Bioquímicas de La Plata |
| description |
Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning. |
| publishDate |
2012 |
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2012 |
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http://sedici.unlp.edu.ar/handle/10915/84080 |
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eng |
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