Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis

Autores
Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; Catalano, Hugo Norberto; Izcovich, Ariel
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.
Fil: Popoff, Federico. Ministerio de Salud de la Nación; Argentina
Fil: Balaciano, Giselle. Hospital Aleman; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Catalano, Hugo Norberto. Ministerio de Salud de la Nación; Argentina
Fil: Izcovich, Ariel. Hospital Aleman; Argentina
Materia
MYOCARDIAL INFARCTION
OMEGA 3 FATTY ACID
POLYUNSATURATED FATTY ACIDS
SECONDARY PREVENTION
SYSTEMATIC REVIEW
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147700
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/147700
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysisPopoff, FedericoBalaciano, GiselleBardach, Ariel EstebanComandé, DanielIrazola, VilmaCatalano, Hugo NorbertoIzcovich, ArielMYOCARDIAL INFARCTIONOMEGA 3 FATTY ACIDPOLYUNSATURATED FATTY ACIDSSECONDARY PREVENTIONSYSTEMATIC REVIEWhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.Fil: Popoff, Federico. Ministerio de Salud de la Nación; ArgentinaFil: Balaciano, Giselle. Hospital Aleman; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Catalano, Hugo Norberto. Ministerio de Salud de la Nación; ArgentinaFil: Izcovich, Ariel. Hospital Aleman; ArgentinaBioMed Central2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147700Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; et al.; Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis; BioMed Central; Bmc Cardiovascular Disorders; 19; 1; 6-2019; 1-131471-2261CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1086-3info:eu-repo/semantics/altIdentifier/doi/10.1186/s12872-019-1086-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:43:55Zoai:ri.conicet.gov.ar:11336/147700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:43:55.817CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
title Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
spellingShingle Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
Popoff, Federico
MYOCARDIAL INFARCTION
OMEGA 3 FATTY ACID
POLYUNSATURATED FATTY ACIDS
SECONDARY PREVENTION
SYSTEMATIC REVIEW
title_short Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
title_full Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
title_fullStr Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
title_full_unstemmed Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
title_sort Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Popoff, Federico
Balaciano, Giselle
Bardach, Ariel Esteban
Comandé, Daniel
Irazola, Vilma
Catalano, Hugo Norberto
Izcovich, Ariel
author Popoff, Federico
author_facet Popoff, Federico
Balaciano, Giselle
Bardach, Ariel Esteban
Comandé, Daniel
Irazola, Vilma
Catalano, Hugo Norberto
Izcovich, Ariel
author_role author
author2 Balaciano, Giselle
Bardach, Ariel Esteban
Comandé, Daniel
Irazola, Vilma
Catalano, Hugo Norberto
Izcovich, Ariel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MYOCARDIAL INFARCTION
OMEGA 3 FATTY ACID
POLYUNSATURATED FATTY ACIDS
SECONDARY PREVENTION
SYSTEMATIC REVIEW
topic MYOCARDIAL INFARCTION
OMEGA 3 FATTY ACID
POLYUNSATURATED FATTY ACIDS
SECONDARY PREVENTION
SYSTEMATIC REVIEW
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.
Fil: Popoff, Federico. Ministerio de Salud de la Nación; Argentina
Fil: Balaciano, Giselle. Hospital Aleman; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Catalano, Hugo Norberto. Ministerio de Salud de la Nación; Argentina
Fil: Izcovich, Ariel. Hospital Aleman; Argentina
description Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147700
Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; et al.; Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis; BioMed Central; Bmc Cardiovascular Disorders; 19; 1; 6-2019; 1-13
1471-2261
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147700
identifier_str_mv Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; et al.; Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis; BioMed Central; Bmc Cardiovascular Disorders; 19; 1; 6-2019; 1-13
1471-2261
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1086-3
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12872-019-1086-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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