Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis
- Autores
- Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; Catalano, Hugo Norberto; Izcovich, Ariel
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.
Fil: Popoff, Federico. Ministerio de Salud de la Nación; Argentina
Fil: Balaciano, Giselle. Hospital Aleman; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Catalano, Hugo Norberto. Ministerio de Salud de la Nación; Argentina
Fil: Izcovich, Ariel. Hospital Aleman; Argentina - Materia
-
MYOCARDIAL INFARCTION
OMEGA 3 FATTY ACID
POLYUNSATURATED FATTY ACIDS
SECONDARY PREVENTION
SYSTEMATIC REVIEW - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/147700
Ver los metadatos del registro completo
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Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysisPopoff, FedericoBalaciano, GiselleBardach, Ariel EstebanComandé, DanielIrazola, VilmaCatalano, Hugo NorbertoIzcovich, ArielMYOCARDIAL INFARCTIONOMEGA 3 FATTY ACIDPOLYUNSATURATED FATTY ACIDSSECONDARY PREVENTIONSYSTEMATIC REVIEWhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.Fil: Popoff, Federico. Ministerio de Salud de la Nación; ArgentinaFil: Balaciano, Giselle. Hospital Aleman; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Catalano, Hugo Norberto. Ministerio de Salud de la Nación; ArgentinaFil: Izcovich, Ariel. Hospital Aleman; ArgentinaBioMed Central2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147700Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; et al.; Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis; BioMed Central; Bmc Cardiovascular Disorders; 19; 1; 6-2019; 1-131471-2261CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1086-3info:eu-repo/semantics/altIdentifier/doi/10.1186/s12872-019-1086-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:55Zoai:ri.conicet.gov.ar:11336/147700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:56.056CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
title |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
spellingShingle |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis Popoff, Federico MYOCARDIAL INFARCTION OMEGA 3 FATTY ACID POLYUNSATURATED FATTY ACIDS SECONDARY PREVENTION SYSTEMATIC REVIEW |
title_short |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
title_full |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
title_fullStr |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
title_full_unstemmed |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
title_sort |
Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis |
dc.creator.none.fl_str_mv |
Popoff, Federico Balaciano, Giselle Bardach, Ariel Esteban Comandé, Daniel Irazola, Vilma Catalano, Hugo Norberto Izcovich, Ariel |
author |
Popoff, Federico |
author_facet |
Popoff, Federico Balaciano, Giselle Bardach, Ariel Esteban Comandé, Daniel Irazola, Vilma Catalano, Hugo Norberto Izcovich, Ariel |
author_role |
author |
author2 |
Balaciano, Giselle Bardach, Ariel Esteban Comandé, Daniel Irazola, Vilma Catalano, Hugo Norberto Izcovich, Ariel |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
MYOCARDIAL INFARCTION OMEGA 3 FATTY ACID POLYUNSATURATED FATTY ACIDS SECONDARY PREVENTION SYSTEMATIC REVIEW |
topic |
MYOCARDIAL INFARCTION OMEGA 3 FATTY ACID POLYUNSATURATED FATTY ACIDS SECONDARY PREVENTION SYSTEMATIC REVIEW |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes. Fil: Popoff, Federico. Ministerio de Salud de la Nación; Argentina Fil: Balaciano, Giselle. Hospital Aleman; Argentina Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Catalano, Hugo Norberto. Ministerio de Salud de la Nación; Argentina Fil: Izcovich, Ariel. Hospital Aleman; Argentina |
description |
Background: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). Methods: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. Study Selection: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. Interventions: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. Results: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). Conclusions: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/147700 Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; et al.; Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis; BioMed Central; Bmc Cardiovascular Disorders; 19; 1; 6-2019; 1-13 1471-2261 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/147700 |
identifier_str_mv |
Popoff, Federico; Balaciano, Giselle; Bardach, Ariel Esteban; Comandé, Daniel; Irazola, Vilma; et al.; Omega 3 fatty acid supplementation after myocardial infarction: A systematic review and meta-analysis; BioMed Central; Bmc Cardiovascular Disorders; 19; 1; 6-2019; 1-13 1471-2261 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1086-3 info:eu-repo/semantics/altIdentifier/doi/10.1186/s12872-019-1086-3 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |