An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma

Autores
Malpica, Luis; Castro, Denisse A.; Enriquez, Daniel J.; Oviedo Pecho, Roberto; Peña, Camila; Idrobo, Henry; Fiad, Lorena; Prates, Maria; Valcarcel, Bryan; Paredes, Antonio; Sánchez, Gadwyn; Moisés, Celia; Castillo, Jorge J.; Villela, Luis; Ramos, Juan C.; Biglione, Mirna Marcela; Beltran, Brady E.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement. Cutaneous involvement was found in 48, 27, 17, and 60% of acute, lymphomatous, chronic and smoldering ATLL cases, respectively. Eight cases had primary cutaneous tumoral variant. Erythroderma (24%) and plaques (22%) were the most frequent skin lesions. The presence of cutaneous involvement was associated with better overall survival compared to non-cutaneous involvement (aHR 0.55 [95% CI: 0.37–0.82], p < 0.01; 1-year OS 53 vs. 27%, respectively, p = 0.012). Combination zidovudine and interferon-alpha (AZT-IFN) yielded high response rates (overall response, OR = 100%, n = 8; complete response 62.5%) compared to chemotherapy (OR = 33.3%, n = 12/36). In conclusion, cutaneous involvement was associated with better survival in Latin American patients with ATLL. AZT-IFN demonstrated encouraging responses in ATLL patients with cutaneous involvement.
Fil: Malpica, Luis. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados Unidos
Fil: Castro, Denisse A.. Universidad de San Martin de Porres; Perú
Fil: Enriquez, Daniel J.. Instituto Nacional de Enfermedades Neoplasicas; Perú
Fil: Oviedo Pecho, Roberto. Pontificia Universidad Católica de Perú; Perú
Fil: Peña, Camila. Genitourinary Medical Oncology Department ; Md Anderson Cancer Center ; University Of Texas;
Fil: Idrobo, Henry. Hospital Universitario del Valle; Colombia
Fil: Fiad, Lorena. Hospital Italiano de La Plata; Argentina
Fil: Prates, Maria. Hospital Italiano de La Plata; Argentina
Fil: Valcarcel, Bryan. The George Washington University; Estados Unidos
Fil: Paredes, Antonio. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Sánchez, Gadwyn. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Moisés, Celia. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Castillo, Jorge J.. Dana Farber Cancer Institute;
Fil: Villela, Luis. Universidad del Valle de Mexico; México
Fil: Ramos, Juan C.. University of Miami; Estados Unidos
Fil: Biglione, Mirna Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Beltran, Brady E.. Hospital Nacional Edgardo Rebagliati Martins; Perú
Materia
HTLV
LEUCEMIA
LINFOMA
LATINOAMERICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267913
Acceder
id CONICETDig_698e2c1eec4a0214d1c2bf645feff63c
oai_identifier_str oai:ri.conicet.gov.ar:11336/267913
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphomaMalpica, LuisCastro, Denisse A.Enriquez, Daniel J.Oviedo Pecho, RobertoPeña, CamilaIdrobo, HenryFiad, LorenaPrates, MariaValcarcel, BryanParedes, AntonioSánchez, GadwynMoisés, CeliaCastillo, Jorge J.Villela, LuisRamos, Juan C.Biglione, Mirna MarcelaBeltran, Brady E.HTLVLEUCEMIALINFOMALATINOAMERICAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement. Cutaneous involvement was found in 48, 27, 17, and 60% of acute, lymphomatous, chronic and smoldering ATLL cases, respectively. Eight cases had primary cutaneous tumoral variant. Erythroderma (24%) and plaques (22%) were the most frequent skin lesions. The presence of cutaneous involvement was associated with better overall survival compared to non-cutaneous involvement (aHR 0.55 [95% CI: 0.37–0.82], p < 0.01; 1-year OS 53 vs. 27%, respectively, p = 0.012). Combination zidovudine and interferon-alpha (AZT-IFN) yielded high response rates (overall response, OR = 100%, n = 8; complete response 62.5%) compared to chemotherapy (OR = 33.3%, n = 12/36). In conclusion, cutaneous involvement was associated with better survival in Latin American patients with ATLL. AZT-IFN demonstrated encouraging responses in ATLL patients with cutaneous involvement.Fil: Malpica, Luis. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados UnidosFil: Castro, Denisse A.. Universidad de San Martin de Porres; PerúFil: Enriquez, Daniel J.. Instituto Nacional de Enfermedades Neoplasicas; PerúFil: Oviedo Pecho, Roberto. Pontificia Universidad Católica de Perú; PerúFil: Peña, Camila. Genitourinary Medical Oncology Department ; Md Anderson Cancer Center ; University Of Texas;Fil: Idrobo, Henry. Hospital Universitario del Valle; ColombiaFil: Fiad, Lorena. Hospital Italiano de La Plata; ArgentinaFil: Prates, Maria. Hospital Italiano de La Plata; ArgentinaFil: Valcarcel, Bryan. The George Washington University; Estados UnidosFil: Paredes, Antonio. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: Sánchez, Gadwyn. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: Moisés, Celia. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: Castillo, Jorge J.. Dana Farber Cancer Institute;Fil: Villela, Luis. Universidad del Valle de Mexico; MéxicoFil: Ramos, Juan C.. University of Miami; Estados UnidosFil: Biglione, Mirna Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Beltran, Brady E.. Hospital Nacional Edgardo Rebagliati Martins; PerúTaylor & Francis Ltd2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267913Malpica, Luis; Castro, Denisse A.; Enriquez, Daniel J.; Oviedo Pecho, Roberto; Peña, Camila; et al.; An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma; Taylor & Francis Ltd; Leukemia and Lymphoma; 63; 2; 9-2021; 315-3251042-8194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/10428194.2021.1984455info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:05Zoai:ri.conicet.gov.ar:11336/267913instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:06.315CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
title An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
spellingShingle An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
Malpica, Luis
HTLV
LEUCEMIA
LINFOMA
LATINOAMERICA
title_short An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
title_full An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
title_fullStr An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
title_full_unstemmed An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
title_sort An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
dc.creator.none.fl_str_mv Malpica, Luis
Castro, Denisse A.
Enriquez, Daniel J.
Oviedo Pecho, Roberto
Peña, Camila
Idrobo, Henry
Fiad, Lorena
Prates, Maria
Valcarcel, Bryan
Paredes, Antonio
Sánchez, Gadwyn
Moisés, Celia
Castillo, Jorge J.
Villela, Luis
Ramos, Juan C.
Biglione, Mirna Marcela
Beltran, Brady E.
author Malpica, Luis
author_facet Malpica, Luis
Castro, Denisse A.
Enriquez, Daniel J.
Oviedo Pecho, Roberto
Peña, Camila
Idrobo, Henry
Fiad, Lorena
Prates, Maria
Valcarcel, Bryan
Paredes, Antonio
Sánchez, Gadwyn
Moisés, Celia
Castillo, Jorge J.
Villela, Luis
Ramos, Juan C.
Biglione, Mirna Marcela
Beltran, Brady E.
author_role author
author2 Castro, Denisse A.
Enriquez, Daniel J.
Oviedo Pecho, Roberto
Peña, Camila
Idrobo, Henry
Fiad, Lorena
Prates, Maria
Valcarcel, Bryan
Paredes, Antonio
Sánchez, Gadwyn
Moisés, Celia
Castillo, Jorge J.
Villela, Luis
Ramos, Juan C.
Biglione, Mirna Marcela
Beltran, Brady E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HTLV
LEUCEMIA
LINFOMA
LATINOAMERICA
topic HTLV
LEUCEMIA
LINFOMA
LATINOAMERICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement. Cutaneous involvement was found in 48, 27, 17, and 60% of acute, lymphomatous, chronic and smoldering ATLL cases, respectively. Eight cases had primary cutaneous tumoral variant. Erythroderma (24%) and plaques (22%) were the most frequent skin lesions. The presence of cutaneous involvement was associated with better overall survival compared to non-cutaneous involvement (aHR 0.55 [95% CI: 0.37–0.82], p < 0.01; 1-year OS 53 vs. 27%, respectively, p = 0.012). Combination zidovudine and interferon-alpha (AZT-IFN) yielded high response rates (overall response, OR = 100%, n = 8; complete response 62.5%) compared to chemotherapy (OR = 33.3%, n = 12/36). In conclusion, cutaneous involvement was associated with better survival in Latin American patients with ATLL. AZT-IFN demonstrated encouraging responses in ATLL patients with cutaneous involvement.
Fil: Malpica, Luis. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados Unidos
Fil: Castro, Denisse A.. Universidad de San Martin de Porres; Perú
Fil: Enriquez, Daniel J.. Instituto Nacional de Enfermedades Neoplasicas; Perú
Fil: Oviedo Pecho, Roberto. Pontificia Universidad Católica de Perú; Perú
Fil: Peña, Camila. Genitourinary Medical Oncology Department ; Md Anderson Cancer Center ; University Of Texas;
Fil: Idrobo, Henry. Hospital Universitario del Valle; Colombia
Fil: Fiad, Lorena. Hospital Italiano de La Plata; Argentina
Fil: Prates, Maria. Hospital Italiano de La Plata; Argentina
Fil: Valcarcel, Bryan. The George Washington University; Estados Unidos
Fil: Paredes, Antonio. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Sánchez, Gadwyn. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Moisés, Celia. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Castillo, Jorge J.. Dana Farber Cancer Institute;
Fil: Villela, Luis. Universidad del Valle de Mexico; México
Fil: Ramos, Juan C.. University of Miami; Estados Unidos
Fil: Biglione, Mirna Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Beltran, Brady E.. Hospital Nacional Edgardo Rebagliati Martins; Perú
description Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement. Cutaneous involvement was found in 48, 27, 17, and 60% of acute, lymphomatous, chronic and smoldering ATLL cases, respectively. Eight cases had primary cutaneous tumoral variant. Erythroderma (24%) and plaques (22%) were the most frequent skin lesions. The presence of cutaneous involvement was associated with better overall survival compared to non-cutaneous involvement (aHR 0.55 [95% CI: 0.37–0.82], p < 0.01; 1-year OS 53 vs. 27%, respectively, p = 0.012). Combination zidovudine and interferon-alpha (AZT-IFN) yielded high response rates (overall response, OR = 100%, n = 8; complete response 62.5%) compared to chemotherapy (OR = 33.3%, n = 12/36). In conclusion, cutaneous involvement was associated with better survival in Latin American patients with ATLL. AZT-IFN demonstrated encouraging responses in ATLL patients with cutaneous involvement.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267913
Malpica, Luis; Castro, Denisse A.; Enriquez, Daniel J.; Oviedo Pecho, Roberto; Peña, Camila; et al.; An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma; Taylor & Francis Ltd; Leukemia and Lymphoma; 63; 2; 9-2021; 315-325
1042-8194
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267913
identifier_str_mv Malpica, Luis; Castro, Denisse A.; Enriquez, Daniel J.; Oviedo Pecho, Roberto; Peña, Camila; et al.; An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma; Taylor & Francis Ltd; Leukemia and Lymphoma; 63; 2; 9-2021; 315-325
1042-8194
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/10428194.2021.1984455
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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