Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis

Autores
Elgoyhen, Ana Belen; Langguth, B.; Nowak, Wanda; Schecklmann, M.; de Ridder, D.; Vanneste, S.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug–target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Langguth, B.. University of Regensburg. Interdisciplinary Tinnitus Clinic. Department of Psychiatry and Psychotherapy; Alemania
Fil: Nowak, Wanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Schecklmann, M.. University of Regensburg. Interdisciplinary Tinnitus Clinic. Department of Psychiatry and Psychotherapy; Alemania
Fil: de Ridder, D.. University of Otago. Dunedin School of Medicine. Unit of Neurosurgery. Department of Surgical Sciences; Nueva Zelanda
Fil: Vanneste, S.. University of Texas at Dallas. School of Behavioral and Brain Sciences. Laboratory for Auditory & Integrative Neuroscience; Estados Unidos
Materia
Tinnitus
Network pharmacology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4010
Acceder
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spelling Identifying Tinnitus-Related Genes Based on a Side-Effect Network AnalysisElgoyhen, Ana BelenLangguth, B.Nowak, WandaSchecklmann, M.de Ridder, D.Vanneste, S.TinnitusNetwork pharmacologyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug–target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Langguth, B.. University of Regensburg. Interdisciplinary Tinnitus Clinic. Department of Psychiatry and Psychotherapy; AlemaniaFil: Nowak, Wanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Schecklmann, M.. University of Regensburg. Interdisciplinary Tinnitus Clinic. Department of Psychiatry and Psychotherapy; AlemaniaFil: de Ridder, D.. University of Otago. Dunedin School of Medicine. Unit of Neurosurgery. Department of Surgical Sciences; Nueva ZelandaFil: Vanneste, S.. University of Texas at Dallas. School of Behavioral and Brain Sciences. Laboratory for Auditory & Integrative Neuroscience; Estados UnidosWiley2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4010Elgoyhen, Ana Belen; Langguth, B.; Nowak, Wanda; Schecklmann, M.; de Ridder, D.; et al.; Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis; Wiley; CPT: Pharmacometrics & Systems Pharmacology; 3; 1; 1-2014; 1-102163-8306enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.75/abstract;jsessionid=9E3152C54341E5E91E35D696B032DFF9.f04t02info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910011/info:eu-repo/semantics/altIdentifier/doi/10.1038%2Fpsp.2013.75info:eu-repo/semantics/altIdentifier/issn/2163-8306info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:14Zoai:ri.conicet.gov.ar:11336/4010instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:14.839CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
title Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
spellingShingle Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
Elgoyhen, Ana Belen
Tinnitus
Network pharmacology
title_short Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
title_full Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
title_fullStr Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
title_full_unstemmed Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
title_sort Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis
dc.creator.none.fl_str_mv Elgoyhen, Ana Belen
Langguth, B.
Nowak, Wanda
Schecklmann, M.
de Ridder, D.
Vanneste, S.
author Elgoyhen, Ana Belen
author_facet Elgoyhen, Ana Belen
Langguth, B.
Nowak, Wanda
Schecklmann, M.
de Ridder, D.
Vanneste, S.
author_role author
author2 Langguth, B.
Nowak, Wanda
Schecklmann, M.
de Ridder, D.
Vanneste, S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Tinnitus
Network pharmacology
topic Tinnitus
Network pharmacology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug–target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Langguth, B.. University of Regensburg. Interdisciplinary Tinnitus Clinic. Department of Psychiatry and Psychotherapy; Alemania
Fil: Nowak, Wanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Schecklmann, M.. University of Regensburg. Interdisciplinary Tinnitus Clinic. Department of Psychiatry and Psychotherapy; Alemania
Fil: de Ridder, D.. University of Otago. Dunedin School of Medicine. Unit of Neurosurgery. Department of Surgical Sciences; Nueva Zelanda
Fil: Vanneste, S.. University of Texas at Dallas. School of Behavioral and Brain Sciences. Laboratory for Auditory & Integrative Neuroscience; Estados Unidos
description Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug–target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4010
Elgoyhen, Ana Belen; Langguth, B.; Nowak, Wanda; Schecklmann, M.; de Ridder, D.; et al.; Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis; Wiley; CPT: Pharmacometrics & Systems Pharmacology; 3; 1; 1-2014; 1-10
2163-8306
url http://hdl.handle.net/11336/4010
identifier_str_mv Elgoyhen, Ana Belen; Langguth, B.; Nowak, Wanda; Schecklmann, M.; de Ridder, D.; et al.; Identifying Tinnitus-Related Genes Based on a Side-Effect Network Analysis; Wiley; CPT: Pharmacometrics & Systems Pharmacology; 3; 1; 1-2014; 1-10
2163-8306
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.75/abstract;jsessionid=9E3152C54341E5E91E35D696B032DFF9.f04t02
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910011/
info:eu-repo/semantics/altIdentifier/doi/10.1038%2Fpsp.2013.75
info:eu-repo/semantics/altIdentifier/issn/2163-8306
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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