Tinnitus: Network path physiology-network pharmacology

Autores
Elgoyhen, Ana Belen; Langguth, Berthold; Vanneste, Sven; de Ridder, Dirk
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. The search for drugs that target tinnitus is hampered by the lack of a deep knowledge of the underlying neural substrates of this pathology. Recent studies are increasingly demonstrating that, as described for other central nervous system disorders, tinnitus is a pathology of brain networks. The application of graph theoretical analysis to brain networks has recently provided new information concerning their topology, their robustness and their vulnerability to attacks. Moreover, the philosophy behind drug design and pharmacotherapy in central nervous system pathologies is changing from that of "magic bullets" that target individual chemoreceptors or "disease-causing genes" into that of "magic shotguns", "promiscuous" or "dirty drugs" that target "disease-causing networks", also known as network pharmacology. In the present work we provide some insight into how this knowledge could be applied to tinnitus pathophysiology and pharmacotherapy.
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Fil: Vanneste, Sven. University Hospital Antwerp; Bélgica
Fil: de Ridder, Dirk. University Hospital Antwerp; Bélgica
Materia
BRAIN NETWORKS
GRAPH ANALYSIS
MAGIC BULLETS
NETWORK PHARMACOLOGY
PHANTOM PERCEPT
SCALE-FREE
SMALL-WORLD
TINNITUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79404
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tinnitus: Network path physiology-network pharmacologyElgoyhen, Ana BelenLangguth, BertholdVanneste, Svende Ridder, DirkBRAIN NETWORKSGRAPH ANALYSISMAGIC BULLETSNETWORK PHARMACOLOGYPHANTOM PERCEPTSCALE-FREESMALL-WORLDTINNITUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. The search for drugs that target tinnitus is hampered by the lack of a deep knowledge of the underlying neural substrates of this pathology. Recent studies are increasingly demonstrating that, as described for other central nervous system disorders, tinnitus is a pathology of brain networks. The application of graph theoretical analysis to brain networks has recently provided new information concerning their topology, their robustness and their vulnerability to attacks. Moreover, the philosophy behind drug design and pharmacotherapy in central nervous system pathologies is changing from that of "magic bullets" that target individual chemoreceptors or "disease-causing genes" into that of "magic shotguns", "promiscuous" or "dirty drugs" that target "disease-causing networks", also known as network pharmacology. In the present work we provide some insight into how this knowledge could be applied to tinnitus pathophysiology and pharmacotherapy.Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Langguth, Berthold. Universitat Regensburg; AlemaniaFil: Vanneste, Sven. University Hospital Antwerp; BélgicaFil: de Ridder, Dirk. University Hospital Antwerp; BélgicaFrontiers2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79404Elgoyhen, Ana Belen; Langguth, Berthold; Vanneste, Sven; de Ridder, Dirk; Tinnitus: Network path physiology-network pharmacology; Frontiers; Frontiers in Systems Neuroscience; Jan; 1-2012; 1-121662-5137CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnsys.2012.00001info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnsys.2012.00001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:49Zoai:ri.conicet.gov.ar:11336/79404instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:49.775CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tinnitus: Network path physiology-network pharmacology
title Tinnitus: Network path physiology-network pharmacology
spellingShingle Tinnitus: Network path physiology-network pharmacology
Elgoyhen, Ana Belen
BRAIN NETWORKS
GRAPH ANALYSIS
MAGIC BULLETS
NETWORK PHARMACOLOGY
PHANTOM PERCEPT
SCALE-FREE
SMALL-WORLD
TINNITUS
title_short Tinnitus: Network path physiology-network pharmacology
title_full Tinnitus: Network path physiology-network pharmacology
title_fullStr Tinnitus: Network path physiology-network pharmacology
title_full_unstemmed Tinnitus: Network path physiology-network pharmacology
title_sort Tinnitus: Network path physiology-network pharmacology
dc.creator.none.fl_str_mv Elgoyhen, Ana Belen
Langguth, Berthold
Vanneste, Sven
de Ridder, Dirk
author Elgoyhen, Ana Belen
author_facet Elgoyhen, Ana Belen
Langguth, Berthold
Vanneste, Sven
de Ridder, Dirk
author_role author
author2 Langguth, Berthold
Vanneste, Sven
de Ridder, Dirk
author2_role author
author
author
dc.subject.none.fl_str_mv BRAIN NETWORKS
GRAPH ANALYSIS
MAGIC BULLETS
NETWORK PHARMACOLOGY
PHANTOM PERCEPT
SCALE-FREE
SMALL-WORLD
TINNITUS
topic BRAIN NETWORKS
GRAPH ANALYSIS
MAGIC BULLETS
NETWORK PHARMACOLOGY
PHANTOM PERCEPT
SCALE-FREE
SMALL-WORLD
TINNITUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. The search for drugs that target tinnitus is hampered by the lack of a deep knowledge of the underlying neural substrates of this pathology. Recent studies are increasingly demonstrating that, as described for other central nervous system disorders, tinnitus is a pathology of brain networks. The application of graph theoretical analysis to brain networks has recently provided new information concerning their topology, their robustness and their vulnerability to attacks. Moreover, the philosophy behind drug design and pharmacotherapy in central nervous system pathologies is changing from that of "magic bullets" that target individual chemoreceptors or "disease-causing genes" into that of "magic shotguns", "promiscuous" or "dirty drugs" that target "disease-causing networks", also known as network pharmacology. In the present work we provide some insight into how this knowledge could be applied to tinnitus pathophysiology and pharmacotherapy.
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Fil: Vanneste, Sven. University Hospital Antwerp; Bélgica
Fil: de Ridder, Dirk. University Hospital Antwerp; Bélgica
description Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. The search for drugs that target tinnitus is hampered by the lack of a deep knowledge of the underlying neural substrates of this pathology. Recent studies are increasingly demonstrating that, as described for other central nervous system disorders, tinnitus is a pathology of brain networks. The application of graph theoretical analysis to brain networks has recently provided new information concerning their topology, their robustness and their vulnerability to attacks. Moreover, the philosophy behind drug design and pharmacotherapy in central nervous system pathologies is changing from that of "magic bullets" that target individual chemoreceptors or "disease-causing genes" into that of "magic shotguns", "promiscuous" or "dirty drugs" that target "disease-causing networks", also known as network pharmacology. In the present work we provide some insight into how this knowledge could be applied to tinnitus pathophysiology and pharmacotherapy.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79404
Elgoyhen, Ana Belen; Langguth, Berthold; Vanneste, Sven; de Ridder, Dirk; Tinnitus: Network path physiology-network pharmacology; Frontiers; Frontiers in Systems Neuroscience; Jan; 1-2012; 1-12
1662-5137
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79404
identifier_str_mv Elgoyhen, Ana Belen; Langguth, Berthold; Vanneste, Sven; de Ridder, Dirk; Tinnitus: Network path physiology-network pharmacology; Frontiers; Frontiers in Systems Neuroscience; Jan; 1-2012; 1-12
1662-5137
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fnsys.2012.00001
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnsys.2012.00001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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