Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Pat...

Autores: Brichetti, Valeria; Rubilar Panasiuk, Cynthia Tamara; Tejada, Julieta; Montecino, Priscila; Crespi Abril, Augusto Cesar; Avaro, Marisa Gladis; de Larrañaga, Gabriela Fernanda; Volonteri, María Clara; Nuñez, María Rosa; Iriarte Vasquez, Javier; Jajati, Mariana; Sivori, Martín; Mangone, Carlos Alberto; Saldarini, Fernando
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Introduction: The global impact of COVID-19 has resulted in a long COVID syndrome, which is defined by persistent symptoms and a significant decline in patients’ quality of life. To address this challenge, we conducted a multicenter, double-blind, randomized study to assess the effects of Echinochrome A, the active principle from sea urchin found in the dietary supplement Echa Marine®, on health-related quality of life and inflammatory biomarkers in 50 long-term COVID patients. Baseline characteristics were similar between groups. Methods: Adult men and non-pregnant women aged 18 to 60 diagnosed with long COVID were randomly assigned to the intervention or control groups. For three months, patients were given daily doses of EchA Marine®, a dietary supplement made from sea urchin eggs, or a matching placebo. The effects of EchA Marine® were assessed using the EuroQol 5-Dimension (EQ-5D) questionnaire and serum parameter measurements. Discussion: Consumers of EchA Marine®exhibited significant reductions in pain, improved mobility, enhanced overall quality of life, and improved inflammation biomarkers. These findings suggest that Echinochrome A, due to its antioxidant and anti-inflammatory properties, effectively alleviates long COVID symptoms, particularly pain and mobility. The results underscore the potential of EchA Marine® as a safe and natural remedy for long COVID patients, warranting further research with larger cohorts to consolidate its efficacy.
Fil: Brichetti, Valeria. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Fil: Rubilar Panasiuk, Cynthia Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; Argentina
Fil: Tejada, Julieta. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Fil: Montecino, Priscila. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Fil: Crespi Abril, Augusto Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; Argentina
Fil: Avaro, Marisa Gladis. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; Argentina
Fil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina
Fil: Volonteri, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina
Fil: Nuñez, María Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Iriarte Vasquez, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Jajati, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Sivori, Martín. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Mangone, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Fil: Saldarini, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Materia: CLINICAL TRIAL
SEA URCHINE
COVID-19
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/278316

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repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid PatientsBrichetti, ValeriaRubilar Panasiuk, Cynthia TamaraTejada, JulietaMontecino, PriscilaCrespi Abril, Augusto CesarAvaro, Marisa Gladisde Larrañaga, Gabriela FernandaVolonteri, María ClaraNuñez, María RosaIriarte Vasquez, JavierJajati, MarianaSivori, MartínMangone, Carlos AlbertoSaldarini, FernandoCLINICAL TRIALSEA URCHINECOVID-19https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: The global impact of COVID-19 has resulted in a long COVID syndrome, which is defined by persistent symptoms and a significant decline in patients’ quality of life. To address this challenge, we conducted a multicenter, double-blind, randomized study to assess the effects of Echinochrome A, the active principle from sea urchin found in the dietary supplement Echa Marine®, on health-related quality of life and inflammatory biomarkers in 50 long-term COVID patients. Baseline characteristics were similar between groups. Methods: Adult men and non-pregnant women aged 18 to 60 diagnosed with long COVID were randomly assigned to the intervention or control groups. For three months, patients were given daily doses of EchA Marine®, a dietary supplement made from sea urchin eggs, or a matching placebo. The effects of EchA Marine® were assessed using the EuroQol 5-Dimension (EQ-5D) questionnaire and serum parameter measurements. Discussion: Consumers of EchA Marine®exhibited significant reductions in pain, improved mobility, enhanced overall quality of life, and improved inflammation biomarkers. These findings suggest that Echinochrome A, due to its antioxidant and anti-inflammatory properties, effectively alleviates long COVID symptoms, particularly pain and mobility. The results underscore the potential of EchA Marine® as a safe and natural remedy for long COVID patients, warranting further research with larger cohorts to consolidate its efficacy.Fil: Brichetti, Valeria. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; ArgentinaFil: Rubilar Panasiuk, Cynthia Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; ArgentinaFil: Tejada, Julieta. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; ArgentinaFil: Montecino, Priscila. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; ArgentinaFil: Crespi Abril, Augusto Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; ArgentinaFil: Avaro, Marisa Gladis. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; ArgentinaFil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Volonteri, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Nuñez, María Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Iriarte Vasquez, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Jajati, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Sivori, Martín. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Mangone, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; ArgentinaFil: Saldarini, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; ArgentinaBiomedical Research Network2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278316Brichetti, Valeria; Rubilar Panasiuk, Cynthia Tamara; Tejada, Julieta; Montecino, Priscila; Crespi Abril, Augusto Cesar; et al.; Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients; Biomedical Research Network; Biomedical Journal of Scientific & Technical Research; 59; 1; 10-2024; 51220-512292574-1241CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://biomedres.us/fulltexts/BJSTR.MS.ID.009252.phpinfo:eu-repo/semantics/altIdentifier/doi/10.26717/BJSTR.2024.59.009252info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T12:53:41Zoai:ri.conicet.gov.ar:11336/278316instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 12:53:41.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
title	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
spellingShingle	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients Brichetti, Valeria CLINICAL TRIAL SEA URCHINE COVID-19
title_short	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
title_full	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
title_fullStr	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
title_full_unstemmed	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
title_sort	Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients
dc.creator.none.fl_str_mv	Brichetti, Valeria Rubilar Panasiuk, Cynthia Tamara Tejada, Julieta Montecino, Priscila Crespi Abril, Augusto Cesar Avaro, Marisa Gladis de Larrañaga, Gabriela Fernanda Volonteri, María Clara Nuñez, María Rosa Iriarte Vasquez, Javier Jajati, Mariana Sivori, Martín Mangone, Carlos Alberto Saldarini, Fernando
author	Brichetti, Valeria
author_facet	Brichetti, Valeria Rubilar Panasiuk, Cynthia Tamara Tejada, Julieta Montecino, Priscila Crespi Abril, Augusto Cesar Avaro, Marisa Gladis de Larrañaga, Gabriela Fernanda Volonteri, María Clara Nuñez, María Rosa Iriarte Vasquez, Javier Jajati, Mariana Sivori, Martín Mangone, Carlos Alberto Saldarini, Fernando
author_role	author
author2	Rubilar Panasiuk, Cynthia Tamara Tejada, Julieta Montecino, Priscila Crespi Abril, Augusto Cesar Avaro, Marisa Gladis de Larrañaga, Gabriela Fernanda Volonteri, María Clara Nuñez, María Rosa Iriarte Vasquez, Javier Jajati, Mariana Sivori, Martín Mangone, Carlos Alberto Saldarini, Fernando
author2_role	author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	CLINICAL TRIAL SEA URCHINE COVID-19
topic	CLINICAL TRIAL SEA URCHINE COVID-19
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	Introduction: The global impact of COVID-19 has resulted in a long COVID syndrome, which is defined by persistent symptoms and a significant decline in patients’ quality of life. To address this challenge, we conducted a multicenter, double-blind, randomized study to assess the effects of Echinochrome A, the active principle from sea urchin found in the dietary supplement Echa Marine®, on health-related quality of life and inflammatory biomarkers in 50 long-term COVID patients. Baseline characteristics were similar between groups. Methods: Adult men and non-pregnant women aged 18 to 60 diagnosed with long COVID were randomly assigned to the intervention or control groups. For three months, patients were given daily doses of EchA Marine®, a dietary supplement made from sea urchin eggs, or a matching placebo. The effects of EchA Marine® were assessed using the EuroQol 5-Dimension (EQ-5D) questionnaire and serum parameter measurements. Discussion: Consumers of EchA Marine®exhibited significant reductions in pain, improved mobility, enhanced overall quality of life, and improved inflammation biomarkers. These findings suggest that Echinochrome A, due to its antioxidant and anti-inflammatory properties, effectively alleviates long COVID symptoms, particularly pain and mobility. The results underscore the potential of EchA Marine® as a safe and natural remedy for long COVID patients, warranting further research with larger cohorts to consolidate its efficacy. Fil: Brichetti, Valeria. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina Fil: Rubilar Panasiuk, Cynthia Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; Argentina Fil: Tejada, Julieta. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina Fil: Montecino, Priscila. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina Fil: Crespi Abril, Augusto Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; Argentina Fil: Avaro, Marisa Gladis. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Puerto Madryn. Instituto Patagónico del Mar; Argentina Fil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina Fil: Volonteri, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina Fil: Nuñez, María Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina Fil: Iriarte Vasquez, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina Fil: Jajati, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina Fil: Sivori, Martín. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina Fil: Mangone, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina Fil: Saldarini, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
description	Introduction: The global impact of COVID-19 has resulted in a long COVID syndrome, which is defined by persistent symptoms and a significant decline in patients’ quality of life. To address this challenge, we conducted a multicenter, double-blind, randomized study to assess the effects of Echinochrome A, the active principle from sea urchin found in the dietary supplement Echa Marine®, on health-related quality of life and inflammatory biomarkers in 50 long-term COVID patients. Baseline characteristics were similar between groups. Methods: Adult men and non-pregnant women aged 18 to 60 diagnosed with long COVID were randomly assigned to the intervention or control groups. For three months, patients were given daily doses of EchA Marine®, a dietary supplement made from sea urchin eggs, or a matching placebo. The effects of EchA Marine® were assessed using the EuroQol 5-Dimension (EQ-5D) questionnaire and serum parameter measurements. Discussion: Consumers of EchA Marine®exhibited significant reductions in pain, improved mobility, enhanced overall quality of life, and improved inflammation biomarkers. These findings suggest that Echinochrome A, due to its antioxidant and anti-inflammatory properties, effectively alleviates long COVID symptoms, particularly pain and mobility. The results underscore the potential of EchA Marine® as a safe and natural remedy for long COVID patients, warranting further research with larger cohorts to consolidate its efficacy.
publishDate	2024
dc.date.none.fl_str_mv	2024-10
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/278316 Brichetti, Valeria; Rubilar Panasiuk, Cynthia Tamara; Tejada, Julieta; Montecino, Priscila; Crespi Abril, Augusto Cesar; et al.; Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients; Biomedical Research Network; Biomedical Journal of Scientific & Technical Research; 59; 1; 10-2024; 51220-51229 2574-1241 CONICET Digital CONICET
url	http://hdl.handle.net/11336/278316
identifier_str_mv	Brichetti, Valeria; Rubilar Panasiuk, Cynthia Tamara; Tejada, Julieta; Montecino, Priscila; Crespi Abril, Augusto Cesar; et al.; Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Patients; Biomedical Research Network; Biomedical Journal of Scientific & Technical Research; 59; 1; 10-2024; 51220-51229 2574-1241 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://biomedres.us/fulltexts/BJSTR.MS.ID.009252.php info:eu-repo/semantics/altIdentifier/doi/10.26717/BJSTR.2024.59.009252
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Biomedical Research Network
publisher.none.fl_str_mv	Biomedical Research Network
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.25844

Clinical Trial to Evaluate the Efficacy of Echinochrome A, An Active Principle of Sea Urchin Eggs, in Improving Quality of Life and Reducing Cellular Inflammation in Long Covid Pat...

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