Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia
- Autores
- Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Herse, Florian; Thijssen, Victor L. J. L.; Weedon Fekjaer, Susanne M.; Schulz, Herbert; Wallukat, Gerd; Klapp, Burghard F.; Nevers, Tania; Sharma, Surendra; Staff, Anne Cathrine; Dechend, Ralf; Blois, Sandra M.
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1– mediated angiogenesis or lectin, galactoside-binding, soluble, 1 de- ficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.
Fil: Freitag, Nancy. Universitätsmedizin Berlin; Alemania
Fil: Tirado González, Irene. Universitätsmedizin Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universitätsmedizin Berlin; Alemania
Fil: Herse, Florian. Max-Delbrück Center for Molecular Medicine; Alemania
Fil: Thijssen, Victor L. J. L.. Vrije Universiteit; Países Bajos
Fil: Weedon Fekjaer, Susanne M.. University Of Oslo; Noruega
Fil: Schulz, Herbert. Max-Delbrück Center for Molecular Medicine; Alemania
Fil: Wallukat, Gerd. Max-Delbrück Center for Molecular Medicine; Alemania
Fil: Klapp, Burghard F.. Universitätsmedizin Berlin; Alemania
Fil: Nevers, Tania. University Brown; Estados Unidos
Fil: Sharma, Surendra. University Brown; Estados Unidos
Fil: Staff, Anne Cathrine. University Of Oslo; Noruega
Fil: Dechend, Ralf. Max-Delbrück Center for Molecular Medicine; Alemania
Fil: Blois, Sandra M.. Universitätsmedizin Berlin; Alemania - Materia
-
Galectin-1
Preeclampsia
Angiogenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/21337
Ver los metadatos del registro completo
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Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsiaFreitag, NancyTirado González, IreneBarrientos, Gabriela LauraHerse, FlorianThijssen, Victor L. J. L.Weedon Fekjaer, Susanne M.Schulz, HerbertWallukat, GerdKlapp, Burghard F.Nevers, TaniaSharma, SurendraStaff, Anne CathrineDechend, RalfBlois, Sandra M.Galectin-1PreeclampsiaAngiogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1– mediated angiogenesis or lectin, galactoside-binding, soluble, 1 de- ficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.Fil: Freitag, Nancy. Universitätsmedizin Berlin; AlemaniaFil: Tirado González, Irene. Universitätsmedizin Berlin; AlemaniaFil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universitätsmedizin Berlin; AlemaniaFil: Herse, Florian. Max-Delbrück Center for Molecular Medicine; AlemaniaFil: Thijssen, Victor L. J. L.. Vrije Universiteit; Países BajosFil: Weedon Fekjaer, Susanne M.. University Of Oslo; NoruegaFil: Schulz, Herbert. Max-Delbrück Center for Molecular Medicine; AlemaniaFil: Wallukat, Gerd. Max-Delbrück Center for Molecular Medicine; AlemaniaFil: Klapp, Burghard F.. Universitätsmedizin Berlin; AlemaniaFil: Nevers, Tania. University Brown; Estados UnidosFil: Sharma, Surendra. University Brown; Estados UnidosFil: Staff, Anne Cathrine. University Of Oslo; NoruegaFil: Dechend, Ralf. Max-Delbrück Center for Molecular Medicine; AlemaniaFil: Blois, Sandra M.. Universitätsmedizin Berlin; AlemaniaNational Academy of Sciences2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21337Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Herse, Florian; Thijssen, Victor L. J. L.; et al.; Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 28; 6-2013; 11451-114560027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1303707110info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/110/28/11451info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:37Zoai:ri.conicet.gov.ar:11336/21337instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:37.988CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| spellingShingle |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia Freitag, Nancy Galectin-1 Preeclampsia Angiogenesis |
| title_short |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_full |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_fullStr |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_full_unstemmed |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_sort |
Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| dc.creator.none.fl_str_mv |
Freitag, Nancy Tirado González, Irene Barrientos, Gabriela Laura Herse, Florian Thijssen, Victor L. J. L. Weedon Fekjaer, Susanne M. Schulz, Herbert Wallukat, Gerd Klapp, Burghard F. Nevers, Tania Sharma, Surendra Staff, Anne Cathrine Dechend, Ralf Blois, Sandra M. |
| author |
Freitag, Nancy |
| author_facet |
Freitag, Nancy Tirado González, Irene Barrientos, Gabriela Laura Herse, Florian Thijssen, Victor L. J. L. Weedon Fekjaer, Susanne M. Schulz, Herbert Wallukat, Gerd Klapp, Burghard F. Nevers, Tania Sharma, Surendra Staff, Anne Cathrine Dechend, Ralf Blois, Sandra M. |
| author_role |
author |
| author2 |
Tirado González, Irene Barrientos, Gabriela Laura Herse, Florian Thijssen, Victor L. J. L. Weedon Fekjaer, Susanne M. Schulz, Herbert Wallukat, Gerd Klapp, Burghard F. Nevers, Tania Sharma, Surendra Staff, Anne Cathrine Dechend, Ralf Blois, Sandra M. |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Galectin-1 Preeclampsia Angiogenesis |
| topic |
Galectin-1 Preeclampsia Angiogenesis |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1– mediated angiogenesis or lectin, galactoside-binding, soluble, 1 de- ficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis. Fil: Freitag, Nancy. Universitätsmedizin Berlin; Alemania Fil: Tirado González, Irene. Universitätsmedizin Berlin; Alemania Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universitätsmedizin Berlin; Alemania Fil: Herse, Florian. Max-Delbrück Center for Molecular Medicine; Alemania Fil: Thijssen, Victor L. J. L.. Vrije Universiteit; Países Bajos Fil: Weedon Fekjaer, Susanne M.. University Of Oslo; Noruega Fil: Schulz, Herbert. Max-Delbrück Center for Molecular Medicine; Alemania Fil: Wallukat, Gerd. Max-Delbrück Center for Molecular Medicine; Alemania Fil: Klapp, Burghard F.. Universitätsmedizin Berlin; Alemania Fil: Nevers, Tania. University Brown; Estados Unidos Fil: Sharma, Surendra. University Brown; Estados Unidos Fil: Staff, Anne Cathrine. University Of Oslo; Noruega Fil: Dechend, Ralf. Max-Delbrück Center for Molecular Medicine; Alemania Fil: Blois, Sandra M.. Universitätsmedizin Berlin; Alemania |
| description |
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1– mediated angiogenesis or lectin, galactoside-binding, soluble, 1 de- ficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-06 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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publishedVersion |
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http://hdl.handle.net/11336/21337 Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Herse, Florian; Thijssen, Victor L. J. L.; et al.; Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 28; 6-2013; 11451-11456 0027-8424 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/21337 |
| identifier_str_mv |
Freitag, Nancy; Tirado González, Irene; Barrientos, Gabriela Laura; Herse, Florian; Thijssen, Victor L. J. L.; et al.; Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 28; 6-2013; 11451-11456 0027-8424 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1303707110 info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/110/28/11451 |
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National Academy of Sciences |
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National Academy of Sciences |
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