Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts

Autores
Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Capparis atamisquea Kuntze (atamisqui) is used in northern Argentina to treat digestive disorders, however, scientific information on its potential therapeutic application has not been established. The study was designed to evaluate the gastroprotective effect and possible involvement mechanism of 5% infusion and 10% hydroalcoholic Capparis atamisquea leaf extracts in experimental model of acute gastric ulceration. Ethanol-induced gastric ulcer model was performed in adult Wistar rats followed by macroscopic and histological analysis, gastric mucus content quantification, mucosal antioxidant system study, myeloperoxidase activity determination and nitric oxide and prostaglandin E2 content. The in vitro antioxidant activities of both extracts were also determined. Pre-treatments with both extracts caused a decrease in ethanol-induced gastric injuries at a macroscopic and microscopic level. A significant increase in gastric mucus content was also observed. The level of nitric oxide and prostaglandin E2 in the gastric mucosa increased significantly in the pre-treatment groups compared to the ulcer control group. These results show the participation of these mediators in the gastroprotective effect. In addition, both extracts showed moderate in vivo and in vitro antioxidant activity. These results contribute to validate the use of this native plant which represents a natural alternative for gastric ulcer prevention.
Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
ANTIULCER ACTIVITY
ATAMISQUI
GASTROPROTECTIVE MECHANISMS
POLAR EXTRACTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214331
Acceder
id CONICETDig_67bc8d2239ca2312b5fec428109cc5e5
oai_identifier_str oai:ri.conicet.gov.ar:11336/214331
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves ExtractsTaboada, Félix FacundoHabib, Natalia CeciliaGenta, Susana Beatriz de FátimaANTIULCER ACTIVITYATAMISQUIGASTROPROTECTIVE MECHANISMSPOLAR EXTRACTShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Capparis atamisquea Kuntze (atamisqui) is used in northern Argentina to treat digestive disorders, however, scientific information on its potential therapeutic application has not been established. The study was designed to evaluate the gastroprotective effect and possible involvement mechanism of 5% infusion and 10% hydroalcoholic Capparis atamisquea leaf extracts in experimental model of acute gastric ulceration. Ethanol-induced gastric ulcer model was performed in adult Wistar rats followed by macroscopic and histological analysis, gastric mucus content quantification, mucosal antioxidant system study, myeloperoxidase activity determination and nitric oxide and prostaglandin E2 content. The in vitro antioxidant activities of both extracts were also determined. Pre-treatments with both extracts caused a decrease in ethanol-induced gastric injuries at a macroscopic and microscopic level. A significant increase in gastric mucus content was also observed. The level of nitric oxide and prostaglandin E2 in the gastric mucosa increased significantly in the pre-treatment groups compared to the ulcer control group. These results show the participation of these mediators in the gastroprotective effect. In addition, both extracts showed moderate in vivo and in vitro antioxidant activity. These results contribute to validate the use of this native plant which represents a natural alternative for gastric ulcer prevention.Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaUniversity of Benin. Faculty of Pharmacy2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214331Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts; University of Benin. Faculty of Pharmacy; Tropical Journal of Natural Product Research; 6; 5; 6-2022; 745-7532616-06842616-0692CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://tjnpr.org/index.php/home/article/view/57info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:26Zoai:ri.conicet.gov.ar:11336/214331instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:27.099CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
title Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
spellingShingle Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
Taboada, Félix Facundo
ANTIULCER ACTIVITY
ATAMISQUI
GASTROPROTECTIVE MECHANISMS
POLAR EXTRACTS
title_short Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
title_full Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
title_fullStr Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
title_full_unstemmed Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
title_sort Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts
dc.creator.none.fl_str_mv Taboada, Félix Facundo
Habib, Natalia Cecilia
Genta, Susana Beatriz de Fátima
author Taboada, Félix Facundo
author_facet Taboada, Félix Facundo
Habib, Natalia Cecilia
Genta, Susana Beatriz de Fátima
author_role author
author2 Habib, Natalia Cecilia
Genta, Susana Beatriz de Fátima
author2_role author
author
dc.subject.none.fl_str_mv ANTIULCER ACTIVITY
ATAMISQUI
GASTROPROTECTIVE MECHANISMS
POLAR EXTRACTS
topic ANTIULCER ACTIVITY
ATAMISQUI
GASTROPROTECTIVE MECHANISMS
POLAR EXTRACTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Capparis atamisquea Kuntze (atamisqui) is used in northern Argentina to treat digestive disorders, however, scientific information on its potential therapeutic application has not been established. The study was designed to evaluate the gastroprotective effect and possible involvement mechanism of 5% infusion and 10% hydroalcoholic Capparis atamisquea leaf extracts in experimental model of acute gastric ulceration. Ethanol-induced gastric ulcer model was performed in adult Wistar rats followed by macroscopic and histological analysis, gastric mucus content quantification, mucosal antioxidant system study, myeloperoxidase activity determination and nitric oxide and prostaglandin E2 content. The in vitro antioxidant activities of both extracts were also determined. Pre-treatments with both extracts caused a decrease in ethanol-induced gastric injuries at a macroscopic and microscopic level. A significant increase in gastric mucus content was also observed. The level of nitric oxide and prostaglandin E2 in the gastric mucosa increased significantly in the pre-treatment groups compared to the ulcer control group. These results show the participation of these mediators in the gastroprotective effect. In addition, both extracts showed moderate in vivo and in vitro antioxidant activity. These results contribute to validate the use of this native plant which represents a natural alternative for gastric ulcer prevention.
Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Capparis atamisquea Kuntze (atamisqui) is used in northern Argentina to treat digestive disorders, however, scientific information on its potential therapeutic application has not been established. The study was designed to evaluate the gastroprotective effect and possible involvement mechanism of 5% infusion and 10% hydroalcoholic Capparis atamisquea leaf extracts in experimental model of acute gastric ulceration. Ethanol-induced gastric ulcer model was performed in adult Wistar rats followed by macroscopic and histological analysis, gastric mucus content quantification, mucosal antioxidant system study, myeloperoxidase activity determination and nitric oxide and prostaglandin E2 content. The in vitro antioxidant activities of both extracts were also determined. Pre-treatments with both extracts caused a decrease in ethanol-induced gastric injuries at a macroscopic and microscopic level. A significant increase in gastric mucus content was also observed. The level of nitric oxide and prostaglandin E2 in the gastric mucosa increased significantly in the pre-treatment groups compared to the ulcer control group. These results show the participation of these mediators in the gastroprotective effect. In addition, both extracts showed moderate in vivo and in vitro antioxidant activity. These results contribute to validate the use of this native plant which represents a natural alternative for gastric ulcer prevention.
publishDate 2022
dc.date.none.fl_str_mv 2022-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214331
Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts; University of Benin. Faculty of Pharmacy; Tropical Journal of Natural Product Research; 6; 5; 6-2022; 745-753
2616-0684
2616-0692
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214331
identifier_str_mv Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Mechanisms Involved in the Antiulcer Activity of Capparis atamisquea Polar Leaves Extracts; University of Benin. Faculty of Pharmacy; Tropical Journal of Natural Product Research; 6; 5; 6-2022; 745-753
2616-0684
2616-0692
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://tjnpr.org/index.php/home/article/view/57
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Benin. Faculty of Pharmacy
publisher.none.fl_str_mv University of Benin. Faculty of Pharmacy
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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