CD137 promotes proliferation and survival of human B cells

Autores
Zhang, Xiaoyu; Voskens, Caroline J.; Sallin, Michelle; Maniar, Amudhan; Montes, Carolina Lucia; Zhang, Yue; Lin, Wei; Li, Guoyan; Burch, Erin; Tan, Ming; Hertzano, Ronna; Chapoval, Andrei I.; Tamada, Koji; Gastman, Brian R.; Schulze, Dan H.; Strome, Scott E.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig–stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-g and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-a and -b. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.
Fil: Zhang, Xiaoyu. University of Maryland; Estados Unidos
Fil: Voskens, Caroline J.. University of Maryland; Estados Unidos
Fil: Sallin, Michelle. University of Maryland; Estados Unidos
Fil: Maniar, Amudhan. University of Maryland; Estados Unidos
Fil: Montes, Carolina Lucia. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Zhang, Yue. University of Maryland; Estados Unidos
Fil: Lin, Wei. University of Maryland; Estados Unidos
Fil: Li, Guoyan. University of Maryland; Estados Unidos
Fil: Burch, Erin. University of Maryland; Estados Unidos
Fil: Tan, Ming. University of Maryland; Estados Unidos
Fil: Hertzano, Ronna. University of Maryland; Estados Unidos
Fil: Chapoval, Andrei I.. University of Maryland; Estados Unidos
Fil: Tamada, Koji. University of Maryland; Estados Unidos
Fil: Gastman, Brian R.. University of Maryland; Estados Unidos
Fil: Schulze, Dan H.. University of Maryland; Estados Unidos
Fil: Strome, Scott E.. University of Maryland; Estados Unidos
Materia
B CELL
CD137
PROLIFERATION
SURVIVAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/187190
Acceder
id CONICETDig_67881b31263e0b5656bcfe7ecd45ac61
oai_identifier_str oai:ri.conicet.gov.ar:11336/187190
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling CD137 promotes proliferation and survival of human B cellsZhang, XiaoyuVoskens, Caroline J.Sallin, MichelleManiar, AmudhanMontes, Carolina LuciaZhang, YueLin, WeiLi, GuoyanBurch, ErinTan, MingHertzano, RonnaChapoval, Andrei I.Tamada, KojiGastman, Brian R.Schulze, Dan H.Strome, Scott E.B CELLCD137PROLIFERATIONSURVIVALhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig–stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-g and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-a and -b. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.Fil: Zhang, Xiaoyu. University of Maryland; Estados UnidosFil: Voskens, Caroline J.. University of Maryland; Estados UnidosFil: Sallin, Michelle. University of Maryland; Estados UnidosFil: Maniar, Amudhan. University of Maryland; Estados UnidosFil: Montes, Carolina Lucia. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Zhang, Yue. University of Maryland; Estados UnidosFil: Lin, Wei. University of Maryland; Estados UnidosFil: Li, Guoyan. University of Maryland; Estados UnidosFil: Burch, Erin. University of Maryland; Estados UnidosFil: Tan, Ming. University of Maryland; Estados UnidosFil: Hertzano, Ronna. University of Maryland; Estados UnidosFil: Chapoval, Andrei I.. University of Maryland; Estados UnidosFil: Tamada, Koji. University of Maryland; Estados UnidosFil: Gastman, Brian R.. University of Maryland; Estados UnidosFil: Schulze, Dan H.. University of Maryland; Estados UnidosFil: Strome, Scott E.. University of Maryland; Estados UnidosAmerican Association of Immunologists2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/187190Zhang, Xiaoyu; Voskens, Caroline J.; Sallin, Michelle; Maniar, Amudhan; Montes, Carolina Lucia; et al.; CD137 promotes proliferation and survival of human B cells; American Association of Immunologists; Journal of Immunology; 184; 2; 1-2010; 787-7950022-17671550-6606CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.aai.org/jimmunol/article/184/2/787/111786/CD137-Promotes-Proliferation-and-Survival-of-Humaninfo:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.0901619info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:04Zoai:ri.conicet.gov.ar:11336/187190instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:04.658CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv CD137 promotes proliferation and survival of human B cells
title CD137 promotes proliferation and survival of human B cells
spellingShingle CD137 promotes proliferation and survival of human B cells
Zhang, Xiaoyu
B CELL
CD137
PROLIFERATION
SURVIVAL
title_short CD137 promotes proliferation and survival of human B cells
title_full CD137 promotes proliferation and survival of human B cells
title_fullStr CD137 promotes proliferation and survival of human B cells
title_full_unstemmed CD137 promotes proliferation and survival of human B cells
title_sort CD137 promotes proliferation and survival of human B cells
dc.creator.none.fl_str_mv Zhang, Xiaoyu
Voskens, Caroline J.
Sallin, Michelle
Maniar, Amudhan
Montes, Carolina Lucia
Zhang, Yue
Lin, Wei
Li, Guoyan
Burch, Erin
Tan, Ming
Hertzano, Ronna
Chapoval, Andrei I.
Tamada, Koji
Gastman, Brian R.
Schulze, Dan H.
Strome, Scott E.
author Zhang, Xiaoyu
author_facet Zhang, Xiaoyu
Voskens, Caroline J.
Sallin, Michelle
Maniar, Amudhan
Montes, Carolina Lucia
Zhang, Yue
Lin, Wei
Li, Guoyan
Burch, Erin
Tan, Ming
Hertzano, Ronna
Chapoval, Andrei I.
Tamada, Koji
Gastman, Brian R.
Schulze, Dan H.
Strome, Scott E.
author_role author
author2 Voskens, Caroline J.
Sallin, Michelle
Maniar, Amudhan
Montes, Carolina Lucia
Zhang, Yue
Lin, Wei
Li, Guoyan
Burch, Erin
Tan, Ming
Hertzano, Ronna
Chapoval, Andrei I.
Tamada, Koji
Gastman, Brian R.
Schulze, Dan H.
Strome, Scott E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv B CELL
CD137
PROLIFERATION
SURVIVAL
topic B CELL
CD137
PROLIFERATION
SURVIVAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig–stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-g and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-a and -b. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.
Fil: Zhang, Xiaoyu. University of Maryland; Estados Unidos
Fil: Voskens, Caroline J.. University of Maryland; Estados Unidos
Fil: Sallin, Michelle. University of Maryland; Estados Unidos
Fil: Maniar, Amudhan. University of Maryland; Estados Unidos
Fil: Montes, Carolina Lucia. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Zhang, Yue. University of Maryland; Estados Unidos
Fil: Lin, Wei. University of Maryland; Estados Unidos
Fil: Li, Guoyan. University of Maryland; Estados Unidos
Fil: Burch, Erin. University of Maryland; Estados Unidos
Fil: Tan, Ming. University of Maryland; Estados Unidos
Fil: Hertzano, Ronna. University of Maryland; Estados Unidos
Fil: Chapoval, Andrei I.. University of Maryland; Estados Unidos
Fil: Tamada, Koji. University of Maryland; Estados Unidos
Fil: Gastman, Brian R.. University of Maryland; Estados Unidos
Fil: Schulze, Dan H.. University of Maryland; Estados Unidos
Fil: Strome, Scott E.. University of Maryland; Estados Unidos
description CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig–stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-g and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-a and -b. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/187190
Zhang, Xiaoyu; Voskens, Caroline J.; Sallin, Michelle; Maniar, Amudhan; Montes, Carolina Lucia; et al.; CD137 promotes proliferation and survival of human B cells; American Association of Immunologists; Journal of Immunology; 184; 2; 1-2010; 787-795
0022-1767
1550-6606
CONICET Digital
CONICET
url http://hdl.handle.net/11336/187190
identifier_str_mv Zhang, Xiaoyu; Voskens, Caroline J.; Sallin, Michelle; Maniar, Amudhan; Montes, Carolina Lucia; et al.; CD137 promotes proliferation and survival of human B cells; American Association of Immunologists; Journal of Immunology; 184; 2; 1-2010; 787-795
0022-1767
1550-6606
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.aai.org/jimmunol/article/184/2/787/111786/CD137-Promotes-Proliferation-and-Survival-of-Human
info:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.0901619
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269988204838912
score 13.13397

Publicaciones similares