Design, characterization and in vitro evaluation of antifungal polymeric films

Autores
Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; Biasoli, Marisa S.; Salomon, Claudio Javier; Olivieri, Alejandro Cesar; Leonardi, Darío
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Martinez, Maria V.. Universidad Nacional de Rosario; Argentina
Fil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Luque, Alicia G.. Universidad Nacional de Rosario; Argentina
Fil: Biasoli, Marisa S.. Universidad Nacional de Rosario; Argentina
Fil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Materia
Drug Delivery Systems
Infrared Spectroscopy
Thermogravimetric Analysis
In-Vitro Models
Anti-Fungal Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6059
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6059
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Design, characterization and in vitro evaluation of antifungal polymeric filmsReal, Daniel AndresMartinez, Maria V.Frattini, Agustin LujanSoazo, Marina del ValleLuque, Alicia G.Biasoli, Marisa S.Salomon, Claudio JavierOlivieri, Alejandro CesarLeonardi, DaríoDrug Delivery SystemsInfrared SpectroscopyThermogravimetric AnalysisIn-Vitro ModelsAnti-Fungal Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Martinez, Maria V.. Universidad Nacional de Rosario; ArgentinaFil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Luque, Alicia G.. Universidad Nacional de Rosario; ArgentinaFil: Biasoli, Marisa S.. Universidad Nacional de Rosario; ArgentinaFil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaSpringer2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6059Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; et al.; Design, characterization and in vitro evaluation of antifungal polymeric films; Springer; AAPS Pharmscitech; 14; 1; 3-2013; 64-731530-9932enginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1208%2Fs12249-012-9894-0info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-012-9894-0info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581640/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:53:03Zoai:ri.conicet.gov.ar:11336/6059instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:53:04.082CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Design, characterization and in vitro evaluation of antifungal polymeric films
title Design, characterization and in vitro evaluation of antifungal polymeric films
spellingShingle Design, characterization and in vitro evaluation of antifungal polymeric films
Real, Daniel Andres
Drug Delivery Systems
Infrared Spectroscopy
Thermogravimetric Analysis
In-Vitro Models
Anti-Fungal Activity
title_short Design, characterization and in vitro evaluation of antifungal polymeric films
title_full Design, characterization and in vitro evaluation of antifungal polymeric films
title_fullStr Design, characterization and in vitro evaluation of antifungal polymeric films
title_full_unstemmed Design, characterization and in vitro evaluation of antifungal polymeric films
title_sort Design, characterization and in vitro evaluation of antifungal polymeric films
dc.creator.none.fl_str_mv Real, Daniel Andres
Martinez, Maria V.
Frattini, Agustin Lujan
Soazo, Marina del Valle
Luque, Alicia G.
Biasoli, Marisa S.
Salomon, Claudio Javier
Olivieri, Alejandro Cesar
Leonardi, Darío
author Real, Daniel Andres
author_facet Real, Daniel Andres
Martinez, Maria V.
Frattini, Agustin Lujan
Soazo, Marina del Valle
Luque, Alicia G.
Biasoli, Marisa S.
Salomon, Claudio Javier
Olivieri, Alejandro Cesar
Leonardi, Darío
author_role author
author2 Martinez, Maria V.
Frattini, Agustin Lujan
Soazo, Marina del Valle
Luque, Alicia G.
Biasoli, Marisa S.
Salomon, Claudio Javier
Olivieri, Alejandro Cesar
Leonardi, Darío
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Drug Delivery Systems
Infrared Spectroscopy
Thermogravimetric Analysis
In-Vitro Models
Anti-Fungal Activity
topic Drug Delivery Systems
Infrared Spectroscopy
Thermogravimetric Analysis
In-Vitro Models
Anti-Fungal Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Martinez, Maria V.. Universidad Nacional de Rosario; Argentina
Fil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Luque, Alicia G.. Universidad Nacional de Rosario; Argentina
Fil: Biasoli, Marisa S.. Universidad Nacional de Rosario; Argentina
Fil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
description The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6059
Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; et al.; Design, characterization and in vitro evaluation of antifungal polymeric films; Springer; AAPS Pharmscitech; 14; 1; 3-2013; 64-73
1530-9932
url http://hdl.handle.net/11336/6059
identifier_str_mv Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; et al.; Design, characterization and in vitro evaluation of antifungal polymeric films; Springer; AAPS Pharmscitech; 14; 1; 3-2013; 64-73
1530-9932
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1208%2Fs12249-012-9894-0
info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-012-9894-0
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581640/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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