Design, characterization and in vitro evaluation of antifungal polymeric films
- Autores
- Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; Biasoli, Marisa S.; Salomon, Claudio Javier; Olivieri, Alejandro Cesar; Leonardi, Darío
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Martinez, Maria V.. Universidad Nacional de Rosario; Argentina
Fil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Luque, Alicia G.. Universidad Nacional de Rosario; Argentina
Fil: Biasoli, Marisa S.. Universidad Nacional de Rosario; Argentina
Fil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina - Materia
-
Drug Delivery Systems
Infrared Spectroscopy
Thermogravimetric Analysis
In-Vitro Models
Anti-Fungal Activity - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/6059
Ver los metadatos del registro completo
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Design, characterization and in vitro evaluation of antifungal polymeric filmsReal, Daniel AndresMartinez, Maria V.Frattini, Agustin LujanSoazo, Marina del ValleLuque, Alicia G.Biasoli, Marisa S.Salomon, Claudio JavierOlivieri, Alejandro CesarLeonardi, DaríoDrug Delivery SystemsInfrared SpectroscopyThermogravimetric AnalysisIn-Vitro ModelsAnti-Fungal Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Martinez, Maria V.. Universidad Nacional de Rosario; ArgentinaFil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Luque, Alicia G.. Universidad Nacional de Rosario; ArgentinaFil: Biasoli, Marisa S.. Universidad Nacional de Rosario; ArgentinaFil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaSpringer2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6059Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; et al.; Design, characterization and in vitro evaluation of antifungal polymeric films; Springer; AAPS Pharmscitech; 14; 1; 3-2013; 64-731530-9932enginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1208%2Fs12249-012-9894-0info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-012-9894-0info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581640/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:24Zoai:ri.conicet.gov.ar:11336/6059instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:25.172CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Design, characterization and in vitro evaluation of antifungal polymeric films |
title |
Design, characterization and in vitro evaluation of antifungal polymeric films |
spellingShingle |
Design, characterization and in vitro evaluation of antifungal polymeric films Real, Daniel Andres Drug Delivery Systems Infrared Spectroscopy Thermogravimetric Analysis In-Vitro Models Anti-Fungal Activity |
title_short |
Design, characterization and in vitro evaluation of antifungal polymeric films |
title_full |
Design, characterization and in vitro evaluation of antifungal polymeric films |
title_fullStr |
Design, characterization and in vitro evaluation of antifungal polymeric films |
title_full_unstemmed |
Design, characterization and in vitro evaluation of antifungal polymeric films |
title_sort |
Design, characterization and in vitro evaluation of antifungal polymeric films |
dc.creator.none.fl_str_mv |
Real, Daniel Andres Martinez, Maria V. Frattini, Agustin Lujan Soazo, Marina del Valle Luque, Alicia G. Biasoli, Marisa S. Salomon, Claudio Javier Olivieri, Alejandro Cesar Leonardi, Darío |
author |
Real, Daniel Andres |
author_facet |
Real, Daniel Andres Martinez, Maria V. Frattini, Agustin Lujan Soazo, Marina del Valle Luque, Alicia G. Biasoli, Marisa S. Salomon, Claudio Javier Olivieri, Alejandro Cesar Leonardi, Darío |
author_role |
author |
author2 |
Martinez, Maria V. Frattini, Agustin Lujan Soazo, Marina del Valle Luque, Alicia G. Biasoli, Marisa S. Salomon, Claudio Javier Olivieri, Alejandro Cesar Leonardi, Darío |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Drug Delivery Systems Infrared Spectroscopy Thermogravimetric Analysis In-Vitro Models Anti-Fungal Activity |
topic |
Drug Delivery Systems Infrared Spectroscopy Thermogravimetric Analysis In-Vitro Models Anti-Fungal Activity |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed. Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Martinez, Maria V.. Universidad Nacional de Rosario; Argentina Fil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina Fil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina Fil: Luque, Alicia G.. Universidad Nacional de Rosario; Argentina Fil: Biasoli, Marisa S.. Universidad Nacional de Rosario; Argentina Fil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina Fil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina Fil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina |
description |
The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/6059 Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; et al.; Design, characterization and in vitro evaluation of antifungal polymeric films; Springer; AAPS Pharmscitech; 14; 1; 3-2013; 64-73 1530-9932 |
url |
http://hdl.handle.net/11336/6059 |
identifier_str_mv |
Real, Daniel Andres; Martinez, Maria V.; Frattini, Agustin Lujan; Soazo, Marina del Valle; Luque, Alicia G.; et al.; Design, characterization and in vitro evaluation of antifungal polymeric films; Springer; AAPS Pharmscitech; 14; 1; 3-2013; 64-73 1530-9932 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1208%2Fs12249-012-9894-0 info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-012-9894-0 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581640/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |