Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study

Autores
Costanzo, Pablo René; Pacenza, Néstor Antonio; Aszpis, Sergio Mario; Suárez, Sebastián Matías; Pragier, Uriel Marcelo; Usher, Jorge Guillermo Stewart; Vásquez Cayoja, Miguel; Iturrieta, Sergio; Gottlieb, Silvia Elisa; Rey, Rodolfo Alberto; Knoblovits, Pablo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives. To evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia in adults. Methods. Medical records of 237 men aged 18-85 years with gynecomastia were evaluated. Results. Highest prevalence of gynecomastia was observed between 21 and 30 years (n = 74; 31.2%). The most common presenting complaints were aesthetic concerns (62.8%) and breast pain (51.2%). 25.3% of the subjects had a history of pubertal gynecomastia. 56.5% had bilateral gynecomastia. 39.9% were overweight and 22.8% were obese. The etiology could not be identified in 45.1% of the cases; the most frequent identified causes were anabolic steroids consumption (13.9%), hypogonadism (11.1%), and use of pharmaceutical drugs (7.8%). Patients with bilateral gynecomastia had a longer history of disease, higher BMI, and lower testosterone levels. Conclusions. Patients with gynecomastia presented more often with aesthetic concerns and secondarily with breast pain. The most frequent final diagnosis was idiopathic gynecomastia, whereas the most frequent identified etiologies were anabolic steroids consumption, hypogonadism, and use of pharmaceutical drugs. Despite the low frequency of etiologies such as thyroid dysfunction or adrenal carcinoma, we emphasize the importance of a thorough assessment of the patient, as gynecomastia may be the tip of the iceberg for the diagnosis of treatable diseases.
Fil: Costanzo, Pablo René. Hospital Italiano; Argentina
Fil: Pacenza, Néstor Antonio. Unidad Asistencial “Dr. Cesar Milstein”,; Argentina. Centro de Endocrinolog´ıa y Diabetes “Dr. Raul Gutman”; Argentina
Fil: Aszpis, Sergio Mario. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Suárez, Sebastián Matías. Hospital Italiano; Argentina
Fil: Pragier, Uriel Marcelo. Complejo Medico Churruca Visca; Argentina
Fil: Usher, Jorge Guillermo Stewart. Centro Medico Haedo; Argentina
Fil: Vásquez Cayoja, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Iturrieta, Sergio. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Knoblovits, Pablo. Hospital Italiano; Argentina
Materia
Gyencomastia
Andrology
Estrogens
Androgens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87169
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/87169
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter StudyCostanzo, Pablo RenéPacenza, Néstor AntonioAszpis, Sergio MarioSuárez, Sebastián MatíasPragier, Uriel MarceloUsher, Jorge Guillermo StewartVásquez Cayoja, MiguelIturrieta, SergioGottlieb, Silvia ElisaRey, Rodolfo AlbertoKnoblovits, PabloGyencomastiaAndrologyEstrogensAndrogenshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives. To evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia in adults. Methods. Medical records of 237 men aged 18-85 years with gynecomastia were evaluated. Results. Highest prevalence of gynecomastia was observed between 21 and 30 years (n = 74; 31.2%). The most common presenting complaints were aesthetic concerns (62.8%) and breast pain (51.2%). 25.3% of the subjects had a history of pubertal gynecomastia. 56.5% had bilateral gynecomastia. 39.9% were overweight and 22.8% were obese. The etiology could not be identified in 45.1% of the cases; the most frequent identified causes were anabolic steroids consumption (13.9%), hypogonadism (11.1%), and use of pharmaceutical drugs (7.8%). Patients with bilateral gynecomastia had a longer history of disease, higher BMI, and lower testosterone levels. Conclusions. Patients with gynecomastia presented more often with aesthetic concerns and secondarily with breast pain. The most frequent final diagnosis was idiopathic gynecomastia, whereas the most frequent identified etiologies were anabolic steroids consumption, hypogonadism, and use of pharmaceutical drugs. Despite the low frequency of etiologies such as thyroid dysfunction or adrenal carcinoma, we emphasize the importance of a thorough assessment of the patient, as gynecomastia may be the tip of the iceberg for the diagnosis of treatable diseases.Fil: Costanzo, Pablo René. Hospital Italiano; ArgentinaFil: Pacenza, Néstor Antonio. Unidad Asistencial “Dr. Cesar Milstein”,; Argentina. Centro de Endocrinolog´ıa y Diabetes “Dr. Raul Gutman”; ArgentinaFil: Aszpis, Sergio Mario. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; ArgentinaFil: Suárez, Sebastián Matías. Hospital Italiano; ArgentinaFil: Pragier, Uriel Marcelo. Complejo Medico Churruca Visca; ArgentinaFil: Usher, Jorge Guillermo Stewart. Centro Medico Haedo; ArgentinaFil: Vásquez Cayoja, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Iturrieta, Sergio. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; ArgentinaFil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Knoblovits, Pablo. Hospital Italiano; ArgentinaHindawi Publishing Corporation2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87169Costanzo, Pablo René; Pacenza, Néstor Antonio; Aszpis, Sergio Mario; Suárez, Sebastián Matías; Pragier, Uriel Marcelo; et al.; Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study; Hindawi Publishing Corporation; BioMed Research International; 2018; 5-2018; 1-7; 83648242314-61332314-6141CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2018/8364824/info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/8364824info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:33Zoai:ri.conicet.gov.ar:11336/87169instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:33.317CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
title Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
spellingShingle Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
Costanzo, Pablo René
Gyencomastia
Andrology
Estrogens
Androgens
title_short Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
title_full Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
title_fullStr Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
title_full_unstemmed Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
title_sort Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study
dc.creator.none.fl_str_mv Costanzo, Pablo René
Pacenza, Néstor Antonio
Aszpis, Sergio Mario
Suárez, Sebastián Matías
Pragier, Uriel Marcelo
Usher, Jorge Guillermo Stewart
Vásquez Cayoja, Miguel
Iturrieta, Sergio
Gottlieb, Silvia Elisa
Rey, Rodolfo Alberto
Knoblovits, Pablo
author Costanzo, Pablo René
author_facet Costanzo, Pablo René
Pacenza, Néstor Antonio
Aszpis, Sergio Mario
Suárez, Sebastián Matías
Pragier, Uriel Marcelo
Usher, Jorge Guillermo Stewart
Vásquez Cayoja, Miguel
Iturrieta, Sergio
Gottlieb, Silvia Elisa
Rey, Rodolfo Alberto
Knoblovits, Pablo
author_role author
author2 Pacenza, Néstor Antonio
Aszpis, Sergio Mario
Suárez, Sebastián Matías
Pragier, Uriel Marcelo
Usher, Jorge Guillermo Stewart
Vásquez Cayoja, Miguel
Iturrieta, Sergio
Gottlieb, Silvia Elisa
Rey, Rodolfo Alberto
Knoblovits, Pablo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Gyencomastia
Andrology
Estrogens
Androgens
topic Gyencomastia
Andrology
Estrogens
Androgens
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives. To evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia in adults. Methods. Medical records of 237 men aged 18-85 years with gynecomastia were evaluated. Results. Highest prevalence of gynecomastia was observed between 21 and 30 years (n = 74; 31.2%). The most common presenting complaints were aesthetic concerns (62.8%) and breast pain (51.2%). 25.3% of the subjects had a history of pubertal gynecomastia. 56.5% had bilateral gynecomastia. 39.9% were overweight and 22.8% were obese. The etiology could not be identified in 45.1% of the cases; the most frequent identified causes were anabolic steroids consumption (13.9%), hypogonadism (11.1%), and use of pharmaceutical drugs (7.8%). Patients with bilateral gynecomastia had a longer history of disease, higher BMI, and lower testosterone levels. Conclusions. Patients with gynecomastia presented more often with aesthetic concerns and secondarily with breast pain. The most frequent final diagnosis was idiopathic gynecomastia, whereas the most frequent identified etiologies were anabolic steroids consumption, hypogonadism, and use of pharmaceutical drugs. Despite the low frequency of etiologies such as thyroid dysfunction or adrenal carcinoma, we emphasize the importance of a thorough assessment of the patient, as gynecomastia may be the tip of the iceberg for the diagnosis of treatable diseases.
Fil: Costanzo, Pablo René. Hospital Italiano; Argentina
Fil: Pacenza, Néstor Antonio. Unidad Asistencial “Dr. Cesar Milstein”,; Argentina. Centro de Endocrinolog´ıa y Diabetes “Dr. Raul Gutman”; Argentina
Fil: Aszpis, Sergio Mario. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Suárez, Sebastián Matías. Hospital Italiano; Argentina
Fil: Pragier, Uriel Marcelo. Complejo Medico Churruca Visca; Argentina
Fil: Usher, Jorge Guillermo Stewart. Centro Medico Haedo; Argentina
Fil: Vásquez Cayoja, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Iturrieta, Sergio. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Knoblovits, Pablo. Hospital Italiano; Argentina
description Objectives. To evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia in adults. Methods. Medical records of 237 men aged 18-85 years with gynecomastia were evaluated. Results. Highest prevalence of gynecomastia was observed between 21 and 30 years (n = 74; 31.2%). The most common presenting complaints were aesthetic concerns (62.8%) and breast pain (51.2%). 25.3% of the subjects had a history of pubertal gynecomastia. 56.5% had bilateral gynecomastia. 39.9% were overweight and 22.8% were obese. The etiology could not be identified in 45.1% of the cases; the most frequent identified causes were anabolic steroids consumption (13.9%), hypogonadism (11.1%), and use of pharmaceutical drugs (7.8%). Patients with bilateral gynecomastia had a longer history of disease, higher BMI, and lower testosterone levels. Conclusions. Patients with gynecomastia presented more often with aesthetic concerns and secondarily with breast pain. The most frequent final diagnosis was idiopathic gynecomastia, whereas the most frequent identified etiologies were anabolic steroids consumption, hypogonadism, and use of pharmaceutical drugs. Despite the low frequency of etiologies such as thyroid dysfunction or adrenal carcinoma, we emphasize the importance of a thorough assessment of the patient, as gynecomastia may be the tip of the iceberg for the diagnosis of treatable diseases.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87169
Costanzo, Pablo René; Pacenza, Néstor Antonio; Aszpis, Sergio Mario; Suárez, Sebastián Matías; Pragier, Uriel Marcelo; et al.; Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study; Hindawi Publishing Corporation; BioMed Research International; 2018; 5-2018; 1-7; 8364824
2314-6133
2314-6141
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87169
identifier_str_mv Costanzo, Pablo René; Pacenza, Néstor Antonio; Aszpis, Sergio Mario; Suárez, Sebastián Matías; Pragier, Uriel Marcelo; et al.; Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study; Hindawi Publishing Corporation; BioMed Research International; 2018; 5-2018; 1-7; 8364824
2314-6133
2314-6141
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2018/8364824/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/8364824
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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