Paediatric and adult-onset male hypogonadism
- Autores
- Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; Rey, Rodolfo Alberto; Hellstrom, Wayne J. G.; Palmert, Mark R.; Corona, Giovanni; Dohle, Gert R.; Khera, Mohit; Chan, Yee-Ming; Maggi, Mario
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.
Fil: Salonia, Andrea. Università Vita-Salute San Raffael; Italia
Fil: Rastrelli, Giulia. University of Florence; Italia
Fil: Hackett, Geoffrey. University of Bedfordshire; Reino Unido
Fil: Seminara, Stephanie B.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; Estados Unidos
Fil: Huhtaniemi, Ilpo T.. University College London; Estados Unidos
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Hellstrom, Wayne J. G.. University of Tulane; Estados Unidos
Fil: Palmert, Mark R.. University of Toronto; Canadá
Fil: Corona, Giovanni. University of Florence; Italia
Fil: Dohle, Gert R.. Erasmus University Medical Centre; Países Bajos
Fil: Khera, Mohit. Baylor College of Medicine;
Fil: Chan, Yee-Ming. Harvard Medical School; Estados Unidos
Fil: Maggi, Mario. University of Florence; Italia - Materia
-
ANDROGENS
AMH
SERTOLI
LEYDIG - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/139079
Ver los metadatos del registro completo
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Paediatric and adult-onset male hypogonadismSalonia, AndreaRastrelli, GiuliaHackett, GeoffreySeminara, Stephanie B.Huhtaniemi, Ilpo T.Rey, Rodolfo AlbertoHellstrom, Wayne J. G.Palmert, Mark R.Corona, GiovanniDohle, Gert R.Khera, MohitChan, Yee-MingMaggi, MarioANDROGENSAMHSERTOLILEYDIGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.Fil: Salonia, Andrea. Università Vita-Salute San Raffael; ItaliaFil: Rastrelli, Giulia. University of Florence; ItaliaFil: Hackett, Geoffrey. University of Bedfordshire; Reino UnidoFil: Seminara, Stephanie B.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; Estados UnidosFil: Huhtaniemi, Ilpo T.. University College London; Estados UnidosFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Hellstrom, Wayne J. G.. University of Tulane; Estados UnidosFil: Palmert, Mark R.. University of Toronto; CanadáFil: Corona, Giovanni. University of Florence; ItaliaFil: Dohle, Gert R.. Erasmus University Medical Centre; Países BajosFil: Khera, Mohit. Baylor College of Medicine;Fil: Chan, Yee-Ming. Harvard Medical School; Estados UnidosFil: Maggi, Mario. University of Florence; ItaliaNature Publishing Group2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139079Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-212056-676X2056-676XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41572-019-0087-yinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41572-019-0087-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:39Zoai:ri.conicet.gov.ar:11336/139079instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:39.717CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Paediatric and adult-onset male hypogonadism |
title |
Paediatric and adult-onset male hypogonadism |
spellingShingle |
Paediatric and adult-onset male hypogonadism Salonia, Andrea ANDROGENS AMH SERTOLI LEYDIG |
title_short |
Paediatric and adult-onset male hypogonadism |
title_full |
Paediatric and adult-onset male hypogonadism |
title_fullStr |
Paediatric and adult-onset male hypogonadism |
title_full_unstemmed |
Paediatric and adult-onset male hypogonadism |
title_sort |
Paediatric and adult-onset male hypogonadism |
dc.creator.none.fl_str_mv |
Salonia, Andrea Rastrelli, Giulia Hackett, Geoffrey Seminara, Stephanie B. Huhtaniemi, Ilpo T. Rey, Rodolfo Alberto Hellstrom, Wayne J. G. Palmert, Mark R. Corona, Giovanni Dohle, Gert R. Khera, Mohit Chan, Yee-Ming Maggi, Mario |
author |
Salonia, Andrea |
author_facet |
Salonia, Andrea Rastrelli, Giulia Hackett, Geoffrey Seminara, Stephanie B. Huhtaniemi, Ilpo T. Rey, Rodolfo Alberto Hellstrom, Wayne J. G. Palmert, Mark R. Corona, Giovanni Dohle, Gert R. Khera, Mohit Chan, Yee-Ming Maggi, Mario |
author_role |
author |
author2 |
Rastrelli, Giulia Hackett, Geoffrey Seminara, Stephanie B. Huhtaniemi, Ilpo T. Rey, Rodolfo Alberto Hellstrom, Wayne J. G. Palmert, Mark R. Corona, Giovanni Dohle, Gert R. Khera, Mohit Chan, Yee-Ming Maggi, Mario |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ANDROGENS AMH SERTOLI LEYDIG |
topic |
ANDROGENS AMH SERTOLI LEYDIG |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development. Fil: Salonia, Andrea. Università Vita-Salute San Raffael; Italia Fil: Rastrelli, Giulia. University of Florence; Italia Fil: Hackett, Geoffrey. University of Bedfordshire; Reino Unido Fil: Seminara, Stephanie B.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; Estados Unidos Fil: Huhtaniemi, Ilpo T.. University College London; Estados Unidos Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Hellstrom, Wayne J. G.. University of Tulane; Estados Unidos Fil: Palmert, Mark R.. University of Toronto; Canadá Fil: Corona, Giovanni. University of Florence; Italia Fil: Dohle, Gert R.. Erasmus University Medical Centre; Países Bajos Fil: Khera, Mohit. Baylor College of Medicine; Fil: Chan, Yee-Ming. Harvard Medical School; Estados Unidos Fil: Maggi, Mario. University of Florence; Italia |
description |
The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/139079 Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-21 2056-676X 2056-676X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/139079 |
identifier_str_mv |
Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-21 2056-676X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41572-019-0087-y info:eu-repo/semantics/altIdentifier/doi/10.1038/s41572-019-0087-y |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269921378041856 |
score |
13.13397 |