A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis

Autores
Fraiman Borrazás, Daniel Edmundo; Ponce Dawson, Silvina Martha
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different. © 2003 Elsevier Ltd. All rights reserved.
Fil: Fraiman Borrazás, Daniel Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Materia
Insp3-Receptor
Luminal Ca2+
Stochastic Model
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/73399
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysisFraiman Borrazás, Daniel EdmundoPonce Dawson, Silvina MarthaInsp3-ReceptorLuminal Ca2+Stochastic Modelhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different. © 2003 Elsevier Ltd. All rights reserved.Fil: Fraiman Borrazás, Daniel Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaChurchill Livingstone2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/73399Fraiman Borrazás, Daniel Edmundo; Ponce Dawson, Silvina Martha; A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis; Churchill Livingstone; Cell Calcium; 35; 5; 12-2004; 403-4130143-4160CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceca.2003.10.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:14:25Zoai:ri.conicet.gov.ar:11336/73399instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:14:25.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
title A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
spellingShingle A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
Fraiman Borrazás, Daniel Edmundo
Insp3-Receptor
Luminal Ca2+
Stochastic Model
title_short A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
title_full A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
title_fullStr A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
title_full_unstemmed A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
title_sort A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis
dc.creator.none.fl_str_mv Fraiman Borrazás, Daniel Edmundo
Ponce Dawson, Silvina Martha
author Fraiman Borrazás, Daniel Edmundo
author_facet Fraiman Borrazás, Daniel Edmundo
Ponce Dawson, Silvina Martha
author_role author
author2 Ponce Dawson, Silvina Martha
author2_role author
dc.subject.none.fl_str_mv Insp3-Receptor
Luminal Ca2+
Stochastic Model
topic Insp3-Receptor
Luminal Ca2+
Stochastic Model
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different. © 2003 Elsevier Ltd. All rights reserved.
Fil: Fraiman Borrazás, Daniel Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
description We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different. © 2003 Elsevier Ltd. All rights reserved.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/73399
Fraiman Borrazás, Daniel Edmundo; Ponce Dawson, Silvina Martha; A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis; Churchill Livingstone; Cell Calcium; 35; 5; 12-2004; 403-413
0143-4160
CONICET Digital
CONICET
url http://hdl.handle.net/11336/73399
identifier_str_mv Fraiman Borrazás, Daniel Edmundo; Ponce Dawson, Silvina Martha; A model of the IP3 receptor with a luminal calcium binding site: Stochastic simulations and analysis; Churchill Livingstone; Cell Calcium; 35; 5; 12-2004; 403-413
0143-4160
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceca.2003.10.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Churchill Livingstone
publisher.none.fl_str_mv Churchill Livingstone
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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