Pharmacological strategies to improve ivermectin efficacy against resistant nematodes

Autores
Lifschitz, Adrian Luis; Entrocasso, Carlos; Alvarez, Luis Ignacio; Lloberas, Maria Mercedes; Ballent, Mariana; Manazza, Jorge; Virkel, Guillermo Leon; Borda, Bernardino; Lanusse, Carlos Edmundo
Año de publicación
2008
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The involvement of the efflux-transport protein P-glycoprotein (Gp-P) on both the pharmacokinetic disposition and resistance mechanisms to macrocyclic lactones has been described. This work aimed to study the effects of loperamide (LPM), a Gp-P modulating agent, on ivermectin (IVM) pharmacokinetics and efficacy against resistant nematodes in sheep. Eighteen Corriedale lambs naturally infested with gastrointestinal nematodes were assigned into three experimental groups. Group A remained as untreated control. Other animals (Groups B and C) received ivermectin either alone or co-administered with LPM (0.2 mg/kg, 2 times every 12 h). Blood samples were collected between up to 14 days post-treatment and IVM plasma concentrations were determined by HPLC. The pattern of efficacy was estimated by the faecal egg count reduction test (FECRT) and adult nematode counts. LPM enhanced the IVM plasma availability (47 %) in co-administered lambs. The FECRT values were increased from 79 % to 96 % in the presence of LPM. The general efficacy against nematodes was increased from 48 % to 77 % after the LPM co-administration. The clinical relevance of this pharmacokinetic/pharmacodynamic interaction is under study in our laboratory.
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Entrocasso, Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lloberas, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Manazza, Jorge. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Borda, Bernardino. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental
Materia
Pharmacological
Strategies
Ivermectin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268502
Acceder
id CONICETDig_656b68fd28d6df2d890d7635eac58aa5
oai_identifier_str oai:ri.conicet.gov.ar:11336/268502
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacological strategies to improve ivermectin efficacy against resistant nematodesLifschitz, Adrian LuisEntrocasso, CarlosAlvarez, Luis IgnacioLloberas, Maria MercedesBallent, MarianaManazza, JorgeVirkel, Guillermo LeonBorda, BernardinoLanusse, Carlos EdmundoPharmacologicalStrategiesIvermectinhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The involvement of the efflux-transport protein P-glycoprotein (Gp-P) on both the pharmacokinetic disposition and resistance mechanisms to macrocyclic lactones has been described. This work aimed to study the effects of loperamide (LPM), a Gp-P modulating agent, on ivermectin (IVM) pharmacokinetics and efficacy against resistant nematodes in sheep. Eighteen Corriedale lambs naturally infested with gastrointestinal nematodes were assigned into three experimental groups. Group A remained as untreated control. Other animals (Groups B and C) received ivermectin either alone or co-administered with LPM (0.2 mg/kg, 2 times every 12 h). Blood samples were collected between up to 14 days post-treatment and IVM plasma concentrations were determined by HPLC. The pattern of efficacy was estimated by the faecal egg count reduction test (FECRT) and adult nematode counts. LPM enhanced the IVM plasma availability (47 %) in co-administered lambs. The FECRT values were increased from 79 % to 96 % in the presence of LPM. The general efficacy against nematodes was increased from 48 % to 77 % after the LPM co-administration. The clinical relevance of this pharmacokinetic/pharmacodynamic interaction is under study in our laboratory.Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Entrocasso, Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lloberas, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; ArgentinaFil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Manazza, Jorge. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; ArgentinaFil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Borda, Bernardino. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaXL Reunión Anual de la Sociedad Argentina de Farmacología ExperimentalTandilArgentinaSociedad Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/268502Pharmacological strategies to improve ivermectin efficacy against resistant nematodes; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 23-23CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:34Zoai:ri.conicet.gov.ar:11336/268502instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:34.651CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
title Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
spellingShingle Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
Lifschitz, Adrian Luis
Pharmacological
Strategies
Ivermectin
title_short Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
title_full Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
title_fullStr Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
title_full_unstemmed Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
title_sort Pharmacological strategies to improve ivermectin efficacy against resistant nematodes
dc.creator.none.fl_str_mv Lifschitz, Adrian Luis
Entrocasso, Carlos
Alvarez, Luis Ignacio
Lloberas, Maria Mercedes
Ballent, Mariana
Manazza, Jorge
Virkel, Guillermo Leon
Borda, Bernardino
Lanusse, Carlos Edmundo
author Lifschitz, Adrian Luis
author_facet Lifschitz, Adrian Luis
Entrocasso, Carlos
Alvarez, Luis Ignacio
Lloberas, Maria Mercedes
Ballent, Mariana
Manazza, Jorge
Virkel, Guillermo Leon
Borda, Bernardino
Lanusse, Carlos Edmundo
author_role author
author2 Entrocasso, Carlos
Alvarez, Luis Ignacio
Lloberas, Maria Mercedes
Ballent, Mariana
Manazza, Jorge
Virkel, Guillermo Leon
Borda, Bernardino
Lanusse, Carlos Edmundo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pharmacological
Strategies
Ivermectin
topic Pharmacological
Strategies
Ivermectin
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The involvement of the efflux-transport protein P-glycoprotein (Gp-P) on both the pharmacokinetic disposition and resistance mechanisms to macrocyclic lactones has been described. This work aimed to study the effects of loperamide (LPM), a Gp-P modulating agent, on ivermectin (IVM) pharmacokinetics and efficacy against resistant nematodes in sheep. Eighteen Corriedale lambs naturally infested with gastrointestinal nematodes were assigned into three experimental groups. Group A remained as untreated control. Other animals (Groups B and C) received ivermectin either alone or co-administered with LPM (0.2 mg/kg, 2 times every 12 h). Blood samples were collected between up to 14 days post-treatment and IVM plasma concentrations were determined by HPLC. The pattern of efficacy was estimated by the faecal egg count reduction test (FECRT) and adult nematode counts. LPM enhanced the IVM plasma availability (47 %) in co-administered lambs. The FECRT values were increased from 79 % to 96 % in the presence of LPM. The general efficacy against nematodes was increased from 48 % to 77 % after the LPM co-administration. The clinical relevance of this pharmacokinetic/pharmacodynamic interaction is under study in our laboratory.
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Entrocasso, Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lloberas, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Manazza, Jorge. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Borda, Bernardino. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental
description The involvement of the efflux-transport protein P-glycoprotein (Gp-P) on both the pharmacokinetic disposition and resistance mechanisms to macrocyclic lactones has been described. This work aimed to study the effects of loperamide (LPM), a Gp-P modulating agent, on ivermectin (IVM) pharmacokinetics and efficacy against resistant nematodes in sheep. Eighteen Corriedale lambs naturally infested with gastrointestinal nematodes were assigned into three experimental groups. Group A remained as untreated control. Other animals (Groups B and C) received ivermectin either alone or co-administered with LPM (0.2 mg/kg, 2 times every 12 h). Blood samples were collected between up to 14 days post-treatment and IVM plasma concentrations were determined by HPLC. The pattern of efficacy was estimated by the faecal egg count reduction test (FECRT) and adult nematode counts. LPM enhanced the IVM plasma availability (47 %) in co-administered lambs. The FECRT values were increased from 79 % to 96 % in the presence of LPM. The general efficacy against nematodes was increased from 48 % to 77 % after the LPM co-administration. The clinical relevance of this pharmacokinetic/pharmacodynamic interaction is under study in our laboratory.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268502
Pharmacological strategies to improve ivermectin efficacy against resistant nematodes; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 23-23
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268502
identifier_str_mv Pharmacological strategies to improve ivermectin efficacy against resistant nematodes; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 23-23
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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