Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium

Autores
Zarate, Gabriela del Valle; Perez Chaia, Adriana Beatriz
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Plant lectins are specific carbohydrate-binding proteins widespread in human and animal diets that cause antinutritional effects. Specific intestinal receptors and microbiota may interact with these dietary components leading to important changes on intestinal physiology. It has been proposed that probiotic microorganisms with suitable surface glycosidic moieties could bind to dietary lectins favoring their elimination from the intestinal lumen or inhibiting their interaction with epithelial cells. In this work, we assessed the effects of Concanavalin A (Con A) on some morphological and physiological parameters related to intestinal functionality such as small bowel architecture, main microflora components and disaccharidase activities of Balb/c mice after long term feeding with this lectin alone (8 mg/kg/day of Con A for 3 weeks) or with the simultaneous consumption of Propionibacterium acidipropionici CRL 1198 (5×108 CFU/mice/day). Long-term consumption of Con A reduced food efficiency suggesting the alteration of the digestion/absorption function of the intestine in the presence of lectin. This effect could be due to both histological alterations of the intestinal epithelium such as shortening and shedding of microvilli and physiological changes like the decrease of disaccharidase activities. Con A feeding increased enterobacteria and enterococci populations whereas lactobacilli, bifidobacteria and propionibacteria were not affected. Consumption of propionibacteria at the same time than Con A, reduced the incidence of Con A-induced alterations in Balb/c mice and may be an effective tool to avoid undesirable lectin-epithelia interactions in both animals and humans.
Fil: Zarate, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perez Chaia, Adriana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Concanavalin A
Propionibacteria
Probiotics
Disaccharidases
Microvilli
Enterobacteria
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24933
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epitheliumZarate, Gabriela del VallePerez Chaia, Adriana BeatrizConcanavalin APropionibacteriaProbioticsDisaccharidasesMicrovilliEnterobacteriahttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Plant lectins are specific carbohydrate-binding proteins widespread in human and animal diets that cause antinutritional effects. Specific intestinal receptors and microbiota may interact with these dietary components leading to important changes on intestinal physiology. It has been proposed that probiotic microorganisms with suitable surface glycosidic moieties could bind to dietary lectins favoring their elimination from the intestinal lumen or inhibiting their interaction with epithelial cells. In this work, we assessed the effects of Concanavalin A (Con A) on some morphological and physiological parameters related to intestinal functionality such as small bowel architecture, main microflora components and disaccharidase activities of Balb/c mice after long term feeding with this lectin alone (8 mg/kg/day of Con A for 3 weeks) or with the simultaneous consumption of Propionibacterium acidipropionici CRL 1198 (5×108 CFU/mice/day). Long-term consumption of Con A reduced food efficiency suggesting the alteration of the digestion/absorption function of the intestine in the presence of lectin. This effect could be due to both histological alterations of the intestinal epithelium such as shortening and shedding of microvilli and physiological changes like the decrease of disaccharidase activities. Con A feeding increased enterobacteria and enterococci populations whereas lactobacilli, bifidobacteria and propionibacteria were not affected. Consumption of propionibacteria at the same time than Con A, reduced the incidence of Con A-induced alterations in Balb/c mice and may be an effective tool to avoid undesirable lectin-epithelia interactions in both animals and humans.Fil: Zarate, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Perez Chaia, Adriana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaElsevier Science Sa2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24933Zarate, Gabriela del Valle; Perez Chaia, Adriana Beatriz; Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium; Elsevier Science Sa; Food Research International; 47; 1; 6-2012; 13-220963-99691873-7145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2012.01.005info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S096399691200035Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:47Zoai:ri.conicet.gov.ar:11336/24933instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:47.876CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
title Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
spellingShingle Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
Zarate, Gabriela del Valle
Concanavalin A
Propionibacteria
Probiotics
Disaccharidases
Microvilli
Enterobacteria
title_short Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
title_full Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
title_fullStr Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
title_full_unstemmed Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
title_sort Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium
dc.creator.none.fl_str_mv Zarate, Gabriela del Valle
Perez Chaia, Adriana Beatriz
author Zarate, Gabriela del Valle
author_facet Zarate, Gabriela del Valle
Perez Chaia, Adriana Beatriz
author_role author
author2 Perez Chaia, Adriana Beatriz
author2_role author
dc.subject.none.fl_str_mv Concanavalin A
Propionibacteria
Probiotics
Disaccharidases
Microvilli
Enterobacteria
topic Concanavalin A
Propionibacteria
Probiotics
Disaccharidases
Microvilli
Enterobacteria
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Plant lectins are specific carbohydrate-binding proteins widespread in human and animal diets that cause antinutritional effects. Specific intestinal receptors and microbiota may interact with these dietary components leading to important changes on intestinal physiology. It has been proposed that probiotic microorganisms with suitable surface glycosidic moieties could bind to dietary lectins favoring their elimination from the intestinal lumen or inhibiting their interaction with epithelial cells. In this work, we assessed the effects of Concanavalin A (Con A) on some morphological and physiological parameters related to intestinal functionality such as small bowel architecture, main microflora components and disaccharidase activities of Balb/c mice after long term feeding with this lectin alone (8 mg/kg/day of Con A for 3 weeks) or with the simultaneous consumption of Propionibacterium acidipropionici CRL 1198 (5×108 CFU/mice/day). Long-term consumption of Con A reduced food efficiency suggesting the alteration of the digestion/absorption function of the intestine in the presence of lectin. This effect could be due to both histological alterations of the intestinal epithelium such as shortening and shedding of microvilli and physiological changes like the decrease of disaccharidase activities. Con A feeding increased enterobacteria and enterococci populations whereas lactobacilli, bifidobacteria and propionibacteria were not affected. Consumption of propionibacteria at the same time than Con A, reduced the incidence of Con A-induced alterations in Balb/c mice and may be an effective tool to avoid undesirable lectin-epithelia interactions in both animals and humans.
Fil: Zarate, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perez Chaia, Adriana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Plant lectins are specific carbohydrate-binding proteins widespread in human and animal diets that cause antinutritional effects. Specific intestinal receptors and microbiota may interact with these dietary components leading to important changes on intestinal physiology. It has been proposed that probiotic microorganisms with suitable surface glycosidic moieties could bind to dietary lectins favoring their elimination from the intestinal lumen or inhibiting their interaction with epithelial cells. In this work, we assessed the effects of Concanavalin A (Con A) on some morphological and physiological parameters related to intestinal functionality such as small bowel architecture, main microflora components and disaccharidase activities of Balb/c mice after long term feeding with this lectin alone (8 mg/kg/day of Con A for 3 weeks) or with the simultaneous consumption of Propionibacterium acidipropionici CRL 1198 (5×108 CFU/mice/day). Long-term consumption of Con A reduced food efficiency suggesting the alteration of the digestion/absorption function of the intestine in the presence of lectin. This effect could be due to both histological alterations of the intestinal epithelium such as shortening and shedding of microvilli and physiological changes like the decrease of disaccharidase activities. Con A feeding increased enterobacteria and enterococci populations whereas lactobacilli, bifidobacteria and propionibacteria were not affected. Consumption of propionibacteria at the same time than Con A, reduced the incidence of Con A-induced alterations in Balb/c mice and may be an effective tool to avoid undesirable lectin-epithelia interactions in both animals and humans.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24933
Zarate, Gabriela del Valle; Perez Chaia, Adriana Beatriz; Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium; Elsevier Science Sa; Food Research International; 47; 1; 6-2012; 13-22
0963-9969
1873-7145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24933
identifier_str_mv Zarate, Gabriela del Valle; Perez Chaia, Adriana Beatriz; Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium; Elsevier Science Sa; Food Research International; 47; 1; 6-2012; 13-22
0963-9969
1873-7145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2012.01.005
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S096399691200035X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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