CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis

Autores
Sampieri, Luciana; Di Giusto, Pablo; Alvarez, Cecilia Ines
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
CREB3 family of transcription factors are ER localized proteins that belong to the bZIP family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases and the released N-terminal domains act as transcription factors. CREB3 family members regulate the expression of a large variety of genes and according to their tissue-specific expression profiles they play, among others, roles in acute phase response, lipid metabolism, development, survival, differentiation, organelle autoregulation, and protein secretion. They have been implicated in the ER and Golgi stress responses as regulators of the cell secretory capacity and cell specific cargos. In this review we provide an overview of the diverse functions of each member of the family (CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4) with special focus on their role in the central nervous system.
Fil: Sampieri, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Di Giusto, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Alvarez, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
CELLULAR HOMEOSTASIS
CENTRAL NERVOUS SYSTEM
CREB3 TRANSCRIPTION FACTORS
ER STRESS RESPONSE
GOLGI STRESS RESPONSE
SECRETORY CAPACITY
SECRETORY PATHWAY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128585
Acceder
id CONICETDig_642cc679489a3550ddc0b571eb0f9ac6
oai_identifier_str oai:ri.conicet.gov.ar:11336/128585
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasisSampieri, LucianaDi Giusto, PabloAlvarez, Cecilia InesCELLULAR HOMEOSTASISCENTRAL NERVOUS SYSTEMCREB3 TRANSCRIPTION FACTORSER STRESS RESPONSEGOLGI STRESS RESPONSESECRETORY CAPACITYSECRETORY PATHWAYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1CREB3 family of transcription factors are ER localized proteins that belong to the bZIP family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases and the released N-terminal domains act as transcription factors. CREB3 family members regulate the expression of a large variety of genes and according to their tissue-specific expression profiles they play, among others, roles in acute phase response, lipid metabolism, development, survival, differentiation, organelle autoregulation, and protein secretion. They have been implicated in the ER and Golgi stress responses as regulators of the cell secretory capacity and cell specific cargos. In this review we provide an overview of the diverse functions of each member of the family (CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4) with special focus on their role in the central nervous system.Fil: Sampieri, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Di Giusto, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Alvarez, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFrontiers Media S.A.2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128585Sampieri, Luciana; Di Giusto, Pablo; Alvarez, Cecilia Ines; CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis; Frontiers Media S.A.; Frontiers in Cell and Developmental Biology; 7; 7-20192296-634XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fcell.2019.00123/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2019.00123info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:06:53Zoai:ri.conicet.gov.ar:11336/128585instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:06:53.952CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
title CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
spellingShingle CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
Sampieri, Luciana
CELLULAR HOMEOSTASIS
CENTRAL NERVOUS SYSTEM
CREB3 TRANSCRIPTION FACTORS
ER STRESS RESPONSE
GOLGI STRESS RESPONSE
SECRETORY CAPACITY
SECRETORY PATHWAY
title_short CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
title_full CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
title_fullStr CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
title_full_unstemmed CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
title_sort CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
dc.creator.none.fl_str_mv Sampieri, Luciana
Di Giusto, Pablo
Alvarez, Cecilia Ines
author Sampieri, Luciana
author_facet Sampieri, Luciana
Di Giusto, Pablo
Alvarez, Cecilia Ines
author_role author
author2 Di Giusto, Pablo
Alvarez, Cecilia Ines
author2_role author
author
dc.subject.none.fl_str_mv CELLULAR HOMEOSTASIS
CENTRAL NERVOUS SYSTEM
CREB3 TRANSCRIPTION FACTORS
ER STRESS RESPONSE
GOLGI STRESS RESPONSE
SECRETORY CAPACITY
SECRETORY PATHWAY
topic CELLULAR HOMEOSTASIS
CENTRAL NERVOUS SYSTEM
CREB3 TRANSCRIPTION FACTORS
ER STRESS RESPONSE
GOLGI STRESS RESPONSE
SECRETORY CAPACITY
SECRETORY PATHWAY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv CREB3 family of transcription factors are ER localized proteins that belong to the bZIP family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases and the released N-terminal domains act as transcription factors. CREB3 family members regulate the expression of a large variety of genes and according to their tissue-specific expression profiles they play, among others, roles in acute phase response, lipid metabolism, development, survival, differentiation, organelle autoregulation, and protein secretion. They have been implicated in the ER and Golgi stress responses as regulators of the cell secretory capacity and cell specific cargos. In this review we provide an overview of the diverse functions of each member of the family (CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4) with special focus on their role in the central nervous system.
Fil: Sampieri, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Di Giusto, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Alvarez, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description CREB3 family of transcription factors are ER localized proteins that belong to the bZIP family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases and the released N-terminal domains act as transcription factors. CREB3 family members regulate the expression of a large variety of genes and according to their tissue-specific expression profiles they play, among others, roles in acute phase response, lipid metabolism, development, survival, differentiation, organelle autoregulation, and protein secretion. They have been implicated in the ER and Golgi stress responses as regulators of the cell secretory capacity and cell specific cargos. In this review we provide an overview of the diverse functions of each member of the family (CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4) with special focus on their role in the central nervous system.
publishDate 2019
dc.date.none.fl_str_mv 2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128585
Sampieri, Luciana; Di Giusto, Pablo; Alvarez, Cecilia Ines; CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis; Frontiers Media S.A.; Frontiers in Cell and Developmental Biology; 7; 7-2019
2296-634X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128585
identifier_str_mv Sampieri, Luciana; Di Giusto, Pablo; Alvarez, Cecilia Ines; CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis; Frontiers Media S.A.; Frontiers in Cell and Developmental Biology; 7; 7-2019
2296-634X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fcell.2019.00123/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2019.00123
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781375357648896
score 12.982451

Publicaciones similares