Efectos centrales de la tintura de Gomphrena perennis

Autores
Consolini, Alicia Elvira; Bonilla, Milena; Garrido, Gabriela; Ragone, María Inés
Año de publicación
2026
Idioma
inglés
Tipo de recurso
conjunto de datos
Estado
Descripción
Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties remain unexplored. The behavioral effects, underlying mechanisms, and acute toxicity of Gomphrena perennis tincture (GphT) were investigated in mice. GphT showed no signs of acute toxicity. Furthermore, it did not alter the number of cross lines in the open field test (OFT), but it induced anxiogenic responses in the elevated plus-maze test (EPM) and the novelty-suppressed feeding test (NSFT), which were reversed by L-NAME, a non-selective nitric oxide synthases inhibitor. GphT also reduced immobility time in the forced swimming test (FST) and the tail suspension test (TST). This antidepressant-like effect was prevented by haloperidol (D1/D2 antagonist), ketanserin (5-HT2A/2C antagonist), L-NAME, and sildenafil (PDE5 inhibitor), while propranolol (β-blocker), prazosin (α1-antagonist), yohimbine (α2-antagonist), and ondansetron (5-HT3-antagonist) did not modify it. Therefore, GphT produced anxiogenic and antidepressant-like effects without impairing locomotion. These effects involve dopaminergic and serotonergic pathways and depend on nitric oxide-mediated signaling, suggesting that GphT exerts a modulatory influence on interconnected neurochemical systems.
Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Bonilla, Milena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Garrido, Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Ragone, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Protección de datos personales (Ley 25.326)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278568
Acceder
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spelling Efectos centrales de la tintura de Gomphrena perennisConsolini, Alicia ElviraBonilla, MilenaGarrido, GabrielaRagone, María Inéshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties remain unexplored. The behavioral effects, underlying mechanisms, and acute toxicity of Gomphrena perennis tincture (GphT) were investigated in mice. GphT showed no signs of acute toxicity. Furthermore, it did not alter the number of cross lines in the open field test (OFT), but it induced anxiogenic responses in the elevated plus-maze test (EPM) and the novelty-suppressed feeding test (NSFT), which were reversed by L-NAME, a non-selective nitric oxide synthases inhibitor. GphT also reduced immobility time in the forced swimming test (FST) and the tail suspension test (TST). This antidepressant-like effect was prevented by haloperidol (D1/D2 antagonist), ketanserin (5-HT2A/2C antagonist), L-NAME, and sildenafil (PDE5 inhibitor), while propranolol (β-blocker), prazosin (α1-antagonist), yohimbine (α2-antagonist), and ondansetron (5-HT3-antagonist) did not modify it. Therefore, GphT produced anxiogenic and antidepressant-like effects without impairing locomotion. These effects involve dopaminergic and serotonergic pathways and depend on nitric oxide-mediated signaling, suggesting that GphT exerts a modulatory influence on interconnected neurochemical systems.Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Bonilla, Milena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Garrido, Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Ragone, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina2026info:ar-repo/semantics/conjuntoDeDatosv1.0info:eu-repo/semantics/dataSetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttp://hdl.handle.net/11336/278568Consolini, Alicia Elvira; Bonilla, Milena; Garrido, Gabriela; Ragone, María Inés; (2026): Efectos centrales de la tintura de Gomphrena perennis. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/278568CONICET DigitalCONICETenginfo:eu-repo/grantAgreement/Universidad Nacional de La Plata/UNLP-X604-PPIDinfo:eu-repo/semantics/restrictedAccessProtección de datos personales (Ley 25.326)reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T12:14:24Zoai:ri.conicet.gov.ar:11336/278568instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 12:14:25.077CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efectos centrales de la tintura de Gomphrena perennis
title Efectos centrales de la tintura de Gomphrena perennis
spellingShingle Efectos centrales de la tintura de Gomphrena perennis
Consolini, Alicia Elvira
title_short Efectos centrales de la tintura de Gomphrena perennis
title_full Efectos centrales de la tintura de Gomphrena perennis
title_fullStr Efectos centrales de la tintura de Gomphrena perennis
title_full_unstemmed Efectos centrales de la tintura de Gomphrena perennis
title_sort Efectos centrales de la tintura de Gomphrena perennis
dc.creator.none.fl_str_mv Consolini, Alicia Elvira
Bonilla, Milena
Garrido, Gabriela
Ragone, María Inés
author Consolini, Alicia Elvira
author_facet Consolini, Alicia Elvira
Bonilla, Milena
Garrido, Gabriela
Ragone, María Inés
author_role author
author2 Bonilla, Milena
Garrido, Gabriela
Ragone, María Inés
author2_role author
author
author
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties remain unexplored. The behavioral effects, underlying mechanisms, and acute toxicity of Gomphrena perennis tincture (GphT) were investigated in mice. GphT showed no signs of acute toxicity. Furthermore, it did not alter the number of cross lines in the open field test (OFT), but it induced anxiogenic responses in the elevated plus-maze test (EPM) and the novelty-suppressed feeding test (NSFT), which were reversed by L-NAME, a non-selective nitric oxide synthases inhibitor. GphT also reduced immobility time in the forced swimming test (FST) and the tail suspension test (TST). This antidepressant-like effect was prevented by haloperidol (D1/D2 antagonist), ketanserin (5-HT2A/2C antagonist), L-NAME, and sildenafil (PDE5 inhibitor), while propranolol (β-blocker), prazosin (α1-antagonist), yohimbine (α2-antagonist), and ondansetron (5-HT3-antagonist) did not modify it. Therefore, GphT produced anxiogenic and antidepressant-like effects without impairing locomotion. These effects involve dopaminergic and serotonergic pathways and depend on nitric oxide-mediated signaling, suggesting that GphT exerts a modulatory influence on interconnected neurochemical systems.
Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Bonilla, Milena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Garrido, Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Ragone, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties remain unexplored. The behavioral effects, underlying mechanisms, and acute toxicity of Gomphrena perennis tincture (GphT) were investigated in mice. GphT showed no signs of acute toxicity. Furthermore, it did not alter the number of cross lines in the open field test (OFT), but it induced anxiogenic responses in the elevated plus-maze test (EPM) and the novelty-suppressed feeding test (NSFT), which were reversed by L-NAME, a non-selective nitric oxide synthases inhibitor. GphT also reduced immobility time in the forced swimming test (FST) and the tail suspension test (TST). This antidepressant-like effect was prevented by haloperidol (D1/D2 antagonist), ketanserin (5-HT2A/2C antagonist), L-NAME, and sildenafil (PDE5 inhibitor), while propranolol (β-blocker), prazosin (α1-antagonist), yohimbine (α2-antagonist), and ondansetron (5-HT3-antagonist) did not modify it. Therefore, GphT produced anxiogenic and antidepressant-like effects without impairing locomotion. These effects involve dopaminergic and serotonergic pathways and depend on nitric oxide-mediated signaling, suggesting that GphT exerts a modulatory influence on interconnected neurochemical systems.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:ar-repo/semantics/conjuntoDeDatos
v1.0
info:eu-repo/semantics/dataSet
format dataSet
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278568
Consolini, Alicia Elvira; Bonilla, Milena; Garrido, Gabriela; Ragone, María Inés; (2026): Efectos centrales de la tintura de Gomphrena perennis. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/278568
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278568
identifier_str_mv Consolini, Alicia Elvira; Bonilla, Milena; Garrido, Gabriela; Ragone, María Inés; (2026): Efectos centrales de la tintura de Gomphrena perennis. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/278568
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/Universidad Nacional de La Plata/UNLP-X604-PPID
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
Protección de datos personales (Ley 25.326)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv Protección de datos personales (Ley 25.326)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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