The arsenal of bioactive molecules in the skin secretion of urodele amphibians

Autores
Barros, Ana L. A. N.; Hamed, Abdelaaty; Marani, Mariela Mirta; Moreira, Daniel C.; Eaton, Peter; Plácido, Alexandra; Kato, Massuo J.; Leite, José Roberto S. A.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxidant, vasoactive, immune system modulation, and dermal wound healing activities. Considering the high demand for new compounds to guide the discovery of new drugs to treat conventional and novel diseases, this review summarizes the characteristics of molecules identified in the skin of urodele amphibians. We describe urodele-derived peptides and alkaloids, with emphasis on their biological activities, which can be considered new scaffolds for the pharmaceutical industry. Although much more attention has been given to anurans, bioactive molecules produced by urodeles have the potential to be used for biotechnological purposes and stand as viable alternatives for the development of therapeutic agents.
Fil: Barros, Ana L. A. N.. Universidade do Brasília; Brasil
Fil: Hamed, Abdelaaty. Universidade de Sao Paulo; Brasil
Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; Argentina
Fil: Moreira, Daniel C.. Universidade do Brasília; Brasil
Fil: Eaton, Peter. Universidad de Porto; Portugal
Fil: Plácido, Alexandra. Universidad de Porto; Portugal
Fil: Kato, Massuo J.. Universidade de Sao Paulo; Brasil
Fil: Leite, José Roberto S. A.. Universidade do Brasília; Brasil
Materia
ALKALOIDS
AMPHIBIANS
BIOACTIVE MOLECULES
PEPTIDES
URODELA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/164877
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The arsenal of bioactive molecules in the skin secretion of urodele amphibiansBarros, Ana L. A. N.Hamed, AbdelaatyMarani, Mariela MirtaMoreira, Daniel C.Eaton, PeterPlácido, AlexandraKato, Massuo J.Leite, José Roberto S. A.ALKALOIDSAMPHIBIANSBIOACTIVE MOLECULESPEPTIDESURODELAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxidant, vasoactive, immune system modulation, and dermal wound healing activities. Considering the high demand for new compounds to guide the discovery of new drugs to treat conventional and novel diseases, this review summarizes the characteristics of molecules identified in the skin of urodele amphibians. We describe urodele-derived peptides and alkaloids, with emphasis on their biological activities, which can be considered new scaffolds for the pharmaceutical industry. Although much more attention has been given to anurans, bioactive molecules produced by urodeles have the potential to be used for biotechnological purposes and stand as viable alternatives for the development of therapeutic agents.Fil: Barros, Ana L. A. N.. Universidade do Brasília; BrasilFil: Hamed, Abdelaaty. Universidade de Sao Paulo; BrasilFil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: Moreira, Daniel C.. Universidade do Brasília; BrasilFil: Eaton, Peter. Universidad de Porto; PortugalFil: Plácido, Alexandra. Universidad de Porto; PortugalFil: Kato, Massuo J.. Universidade de Sao Paulo; BrasilFil: Leite, José Roberto S. A.. Universidade do Brasília; BrasilFrontiers Media2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164877Barros, Ana L. A. N.; Hamed, Abdelaaty; Marani, Mariela Mirta; Moreira, Daniel C.; Eaton, Peter; et al.; The arsenal of bioactive molecules in the skin secretion of urodele amphibians; Frontiers Media; Frontiers in Pharmacology; 12; 1-2022; 1-71663-9812CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2021.810821/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2021.810821info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:40:11Zoai:ri.conicet.gov.ar:11336/164877instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:40:12.207CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The arsenal of bioactive molecules in the skin secretion of urodele amphibians
title The arsenal of bioactive molecules in the skin secretion of urodele amphibians
spellingShingle The arsenal of bioactive molecules in the skin secretion of urodele amphibians
Barros, Ana L. A. N.
ALKALOIDS
AMPHIBIANS
BIOACTIVE MOLECULES
PEPTIDES
URODELA
title_short The arsenal of bioactive molecules in the skin secretion of urodele amphibians
title_full The arsenal of bioactive molecules in the skin secretion of urodele amphibians
title_fullStr The arsenal of bioactive molecules in the skin secretion of urodele amphibians
title_full_unstemmed The arsenal of bioactive molecules in the skin secretion of urodele amphibians
title_sort The arsenal of bioactive molecules in the skin secretion of urodele amphibians
dc.creator.none.fl_str_mv Barros, Ana L. A. N.
Hamed, Abdelaaty
Marani, Mariela Mirta
Moreira, Daniel C.
Eaton, Peter
Plácido, Alexandra
Kato, Massuo J.
Leite, José Roberto S. A.
author Barros, Ana L. A. N.
author_facet Barros, Ana L. A. N.
Hamed, Abdelaaty
Marani, Mariela Mirta
Moreira, Daniel C.
Eaton, Peter
Plácido, Alexandra
Kato, Massuo J.
Leite, José Roberto S. A.
author_role author
author2 Hamed, Abdelaaty
Marani, Mariela Mirta
Moreira, Daniel C.
Eaton, Peter
Plácido, Alexandra
Kato, Massuo J.
Leite, José Roberto S. A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALKALOIDS
AMPHIBIANS
BIOACTIVE MOLECULES
PEPTIDES
URODELA
topic ALKALOIDS
AMPHIBIANS
BIOACTIVE MOLECULES
PEPTIDES
URODELA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxidant, vasoactive, immune system modulation, and dermal wound healing activities. Considering the high demand for new compounds to guide the discovery of new drugs to treat conventional and novel diseases, this review summarizes the characteristics of molecules identified in the skin of urodele amphibians. We describe urodele-derived peptides and alkaloids, with emphasis on their biological activities, which can be considered new scaffolds for the pharmaceutical industry. Although much more attention has been given to anurans, bioactive molecules produced by urodeles have the potential to be used for biotechnological purposes and stand as viable alternatives for the development of therapeutic agents.
Fil: Barros, Ana L. A. N.. Universidade do Brasília; Brasil
Fil: Hamed, Abdelaaty. Universidade de Sao Paulo; Brasil
Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; Argentina
Fil: Moreira, Daniel C.. Universidade do Brasília; Brasil
Fil: Eaton, Peter. Universidad de Porto; Portugal
Fil: Plácido, Alexandra. Universidad de Porto; Portugal
Fil: Kato, Massuo J.. Universidade de Sao Paulo; Brasil
Fil: Leite, José Roberto S. A.. Universidade do Brasília; Brasil
description Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxidant, vasoactive, immune system modulation, and dermal wound healing activities. Considering the high demand for new compounds to guide the discovery of new drugs to treat conventional and novel diseases, this review summarizes the characteristics of molecules identified in the skin of urodele amphibians. We describe urodele-derived peptides and alkaloids, with emphasis on their biological activities, which can be considered new scaffolds for the pharmaceutical industry. Although much more attention has been given to anurans, bioactive molecules produced by urodeles have the potential to be used for biotechnological purposes and stand as viable alternatives for the development of therapeutic agents.
publishDate 2022
dc.date.none.fl_str_mv 2022-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164877
Barros, Ana L. A. N.; Hamed, Abdelaaty; Marani, Mariela Mirta; Moreira, Daniel C.; Eaton, Peter; et al.; The arsenal of bioactive molecules in the skin secretion of urodele amphibians; Frontiers Media; Frontiers in Pharmacology; 12; 1-2022; 1-7
1663-9812
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164877
identifier_str_mv Barros, Ana L. A. N.; Hamed, Abdelaaty; Marani, Mariela Mirta; Moreira, Daniel C.; Eaton, Peter; et al.; The arsenal of bioactive molecules in the skin secretion of urodele amphibians; Frontiers Media; Frontiers in Pharmacology; 12; 1-2022; 1-7
1663-9812
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2021.810821/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2021.810821
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1849872391570718720
score 13.011256

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