An update of biocatalytic selective acylation and deacylation of monosaccharides

Autores
Iribarren, Adolfo Marcelo; Iglesias, Luis Emilio
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided by biocatalytic processes and in particular by hydrolases, which offer mild conditions and selective routes for the preparation of PAMs. Since this strategy has been extensively explored, the aim of the present review is to update research on enzymatic selective acylation and deacylation of monosaccharides, focusing on enzymatic preparation of synthetic useful PAMs and drug–monosaccharide conjugates involving PAMs.
Fil: Iribarren, Adolfo Marcelo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Iglesias, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina
Materia
MONOSACCHARIDES
ACYLATION
DEACYLATION
BIOCATALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102968
Acceder
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network_name_str CONICET Digital (CONICET)
spelling An update of biocatalytic selective acylation and deacylation of monosaccharidesIribarren, Adolfo MarceloIglesias, Luis EmilioMONOSACCHARIDESACYLATIONDEACYLATIONBIOCATALYSIShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided by biocatalytic processes and in particular by hydrolases, which offer mild conditions and selective routes for the preparation of PAMs. Since this strategy has been extensively explored, the aim of the present review is to update research on enzymatic selective acylation and deacylation of monosaccharides, focusing on enzymatic preparation of synthetic useful PAMs and drug–monosaccharide conjugates involving PAMs.Fil: Iribarren, Adolfo Marcelo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Iglesias, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; ArgentinaRoyal Society of Chemistry2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102968Iribarren, Adolfo Marcelo; Iglesias, Luis Emilio; An update of biocatalytic selective acylation and deacylation of monosaccharides; Royal Society of Chemistry; RSC Advances; 6; 20; 3-2016; 16358-163862046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c5ra23453kinfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2016/RA/C5RA23453Kinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:37:16Zoai:ri.conicet.gov.ar:11336/102968instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:37:17.061CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An update of biocatalytic selective acylation and deacylation of monosaccharides
title An update of biocatalytic selective acylation and deacylation of monosaccharides
spellingShingle An update of biocatalytic selective acylation and deacylation of monosaccharides
Iribarren, Adolfo Marcelo
MONOSACCHARIDES
ACYLATION
DEACYLATION
BIOCATALYSIS
title_short An update of biocatalytic selective acylation and deacylation of monosaccharides
title_full An update of biocatalytic selective acylation and deacylation of monosaccharides
title_fullStr An update of biocatalytic selective acylation and deacylation of monosaccharides
title_full_unstemmed An update of biocatalytic selective acylation and deacylation of monosaccharides
title_sort An update of biocatalytic selective acylation and deacylation of monosaccharides
dc.creator.none.fl_str_mv Iribarren, Adolfo Marcelo
Iglesias, Luis Emilio
author Iribarren, Adolfo Marcelo
author_facet Iribarren, Adolfo Marcelo
Iglesias, Luis Emilio
author_role author
author2 Iglesias, Luis Emilio
author2_role author
dc.subject.none.fl_str_mv MONOSACCHARIDES
ACYLATION
DEACYLATION
BIOCATALYSIS
topic MONOSACCHARIDES
ACYLATION
DEACYLATION
BIOCATALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided by biocatalytic processes and in particular by hydrolases, which offer mild conditions and selective routes for the preparation of PAMs. Since this strategy has been extensively explored, the aim of the present review is to update research on enzymatic selective acylation and deacylation of monosaccharides, focusing on enzymatic preparation of synthetic useful PAMs and drug–monosaccharide conjugates involving PAMs.
Fil: Iribarren, Adolfo Marcelo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Iglesias, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina
description Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided by biocatalytic processes and in particular by hydrolases, which offer mild conditions and selective routes for the preparation of PAMs. Since this strategy has been extensively explored, the aim of the present review is to update research on enzymatic selective acylation and deacylation of monosaccharides, focusing on enzymatic preparation of synthetic useful PAMs and drug–monosaccharide conjugates involving PAMs.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102968
Iribarren, Adolfo Marcelo; Iglesias, Luis Emilio; An update of biocatalytic selective acylation and deacylation of monosaccharides; Royal Society of Chemistry; RSC Advances; 6; 20; 3-2016; 16358-16386
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102968
identifier_str_mv Iribarren, Adolfo Marcelo; Iglesias, Luis Emilio; An update of biocatalytic selective acylation and deacylation of monosaccharides; Royal Society of Chemistry; RSC Advances; 6; 20; 3-2016; 16358-16386
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c5ra23453k
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2016/RA/C5RA23453K
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.142177

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