Biocatalytic approaches applied to the synthesis of nucleoside prodrugs

Autores
Iglesias, Luis Emilio; Lewkowicz, Elizabeth Sandra; Médici, Rosario; Bianchi, Paola; Iribarren, Adolfo Marcelo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside chemistry. In this context, the aim of this review is to give an overview of the opportunities provided by biocatalytic procedures in the preparation of nucleoside prodrugs. The potential of biocatalysis in this research area will be presented through examples covering the different types of nucleoside prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic prodrugs and nucleoside hydrophilic prodrugs.
Fil: Iglesias, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Lewkowicz, Elizabeth Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Médici, Rosario. Delft University of Technology; Países Bajos
Fil: Bianchi, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
Materia
Biocatalysis
Nucleosides
Prodrugs
Chemoenzymatic Synthesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41619
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Biocatalytic approaches applied to the synthesis of nucleoside prodrugsIglesias, Luis EmilioLewkowicz, Elizabeth SandraMédici, RosarioBianchi, PaolaIribarren, Adolfo MarceloBiocatalysisNucleosidesProdrugsChemoenzymatic Synthesishttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside chemistry. In this context, the aim of this review is to give an overview of the opportunities provided by biocatalytic procedures in the preparation of nucleoside prodrugs. The potential of biocatalysis in this research area will be presented through examples covering the different types of nucleoside prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic prodrugs and nucleoside hydrophilic prodrugs.Fil: Iglesias, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; ArgentinaFil: Lewkowicz, Elizabeth Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; ArgentinaFil: Médici, Rosario. Delft University of Technology; Países BajosFil: Bianchi, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; ArgentinaFil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; ArgentinaPergamon-Elsevier Science Ltd2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41619Iglesias, Luis Emilio; Lewkowicz, Elizabeth Sandra; Médici, Rosario; Bianchi, Paola; Iribarren, Adolfo Marcelo; Biocatalytic approaches applied to the synthesis of nucleoside prodrugs; Pergamon-Elsevier Science Ltd; Biotechnology Advances; 33; 5; 6-2015; 412-4340734-9750CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2015.03.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0734975015000592info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:02Zoai:ri.conicet.gov.ar:11336/41619instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:02.963CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
title Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
spellingShingle Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
Iglesias, Luis Emilio
Biocatalysis
Nucleosides
Prodrugs
Chemoenzymatic Synthesis
title_short Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
title_full Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
title_fullStr Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
title_full_unstemmed Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
title_sort Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
dc.creator.none.fl_str_mv Iglesias, Luis Emilio
Lewkowicz, Elizabeth Sandra
Médici, Rosario
Bianchi, Paola
Iribarren, Adolfo Marcelo
author Iglesias, Luis Emilio
author_facet Iglesias, Luis Emilio
Lewkowicz, Elizabeth Sandra
Médici, Rosario
Bianchi, Paola
Iribarren, Adolfo Marcelo
author_role author
author2 Lewkowicz, Elizabeth Sandra
Médici, Rosario
Bianchi, Paola
Iribarren, Adolfo Marcelo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biocatalysis
Nucleosides
Prodrugs
Chemoenzymatic Synthesis
topic Biocatalysis
Nucleosides
Prodrugs
Chemoenzymatic Synthesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside chemistry. In this context, the aim of this review is to give an overview of the opportunities provided by biocatalytic procedures in the preparation of nucleoside prodrugs. The potential of biocatalysis in this research area will be presented through examples covering the different types of nucleoside prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic prodrugs and nucleoside hydrophilic prodrugs.
Fil: Iglesias, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Lewkowicz, Elizabeth Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Médici, Rosario. Delft University of Technology; Países Bajos
Fil: Bianchi, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
description Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside chemistry. In this context, the aim of this review is to give an overview of the opportunities provided by biocatalytic procedures in the preparation of nucleoside prodrugs. The potential of biocatalysis in this research area will be presented through examples covering the different types of nucleoside prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic prodrugs and nucleoside hydrophilic prodrugs.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41619
Iglesias, Luis Emilio; Lewkowicz, Elizabeth Sandra; Médici, Rosario; Bianchi, Paola; Iribarren, Adolfo Marcelo; Biocatalytic approaches applied to the synthesis of nucleoside prodrugs; Pergamon-Elsevier Science Ltd; Biotechnology Advances; 33; 5; 6-2015; 412-434
0734-9750
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41619
identifier_str_mv Iglesias, Luis Emilio; Lewkowicz, Elizabeth Sandra; Médici, Rosario; Bianchi, Paola; Iribarren, Adolfo Marcelo; Biocatalytic approaches applied to the synthesis of nucleoside prodrugs; Pergamon-Elsevier Science Ltd; Biotechnology Advances; 33; 5; 6-2015; 412-434
0734-9750
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2015.03.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0734975015000592
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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