Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence

Autores
Mondragon, Leonel; Richard, Silvina Mariel; Martinez Marignac, Veronica Lucrecia
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An inverse association between malaria infection and risk of cancer has been established worldwide, however nutritional, economical incomes, social parameters bias and cancer risk increased by year related to life style and other factors have not been studied in an endemic malaria region such as those in South America. The present analysis examines the association by malaria and cancer and neoplasm incidence, restricting analyses to studies performed by the Institute for Health Metrics and Evaluation (IHME) where data for South America for endemic countries (Suriname, Guyana, Ecuador, Peru, Venezuela, Colombia, Brazil, Bolivia) and non malaria endemic countries were available (Argentina, Paraguay). Uruguay and Chile were included as outliers per more than 10 years with no reported cases of Malaria. The authors reviewed available databases through 30 years, examining both sexes, people of 25 year of age and olders, and analyzed the association between malaria, year of incidence, nutrition and risk of having different types of cancers and neoplasm as they were defined by Global Health Data Exchange (GHDx) and IHME. An inverse association between malaria total cancer and a strong negative correlation with neoplasm was found in both sexes. This study confirms previous studies reporting an inverse association between malaria and cancer and provides quantitative estimates of the inverse association in South American countries. We suggest that two malaria non-endemic countries (Chile and Uruguay) have an elevated risk level of cancer incidence. We discuss possible mechanism of malaria infection as an antagonist to cancer or neoplasm development.
Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina
Fil: Richard, Silvina Mariel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina
Materia
MALARIA
CANCER
CROSS IMMUNE RESPONSE
ENDEMIC ZONE
SOUTH AMERICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256286
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/256286
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer IncidenceMondragon, LeonelRichard, Silvina MarielMartinez Marignac, Veronica LucreciaMALARIACANCERCROSS IMMUNE RESPONSEENDEMIC ZONESOUTH AMERICAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3An inverse association between malaria infection and risk of cancer has been established worldwide, however nutritional, economical incomes, social parameters bias and cancer risk increased by year related to life style and other factors have not been studied in an endemic malaria region such as those in South America. The present analysis examines the association by malaria and cancer and neoplasm incidence, restricting analyses to studies performed by the Institute for Health Metrics and Evaluation (IHME) where data for South America for endemic countries (Suriname, Guyana, Ecuador, Peru, Venezuela, Colombia, Brazil, Bolivia) and non malaria endemic countries were available (Argentina, Paraguay). Uruguay and Chile were included as outliers per more than 10 years with no reported cases of Malaria. The authors reviewed available databases through 30 years, examining both sexes, people of 25 year of age and olders, and analyzed the association between malaria, year of incidence, nutrition and risk of having different types of cancers and neoplasm as they were defined by Global Health Data Exchange (GHDx) and IHME. An inverse association between malaria total cancer and a strong negative correlation with neoplasm was found in both sexes. This study confirms previous studies reporting an inverse association between malaria and cancer and provides quantitative estimates of the inverse association in South American countries. We suggest that two malaria non-endemic countries (Chile and Uruguay) have an elevated risk level of cancer incidence. We discuss possible mechanism of malaria infection as an antagonist to cancer or neoplasm development.Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; ArgentinaFil: Richard, Silvina Mariel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; ArgentinaVcare Clinic and Research Center2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256286Mondragon, Leonel; Richard, Silvina Mariel; Martinez Marignac, Veronica Lucrecia; Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence; Vcare Clinic and Research Center; Journal of Medical Research and Health Sciences; 7; 2; 2-2024; 3004-30122589-90232589-9031CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jmrhs.info/index.php/jmrhs/article/view/690info:eu-repo/semantics/altIdentifier/doi/10.52845/JMRHS/2024-7-2-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:38Zoai:ri.conicet.gov.ar:11336/256286instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:38.579CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
title Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
spellingShingle Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
Mondragon, Leonel
MALARIA
CANCER
CROSS IMMUNE RESPONSE
ENDEMIC ZONE
SOUTH AMERICA
title_short Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
title_full Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
title_fullStr Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
title_full_unstemmed Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
title_sort Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence
dc.creator.none.fl_str_mv Mondragon, Leonel
Richard, Silvina Mariel
Martinez Marignac, Veronica Lucrecia
author Mondragon, Leonel
author_facet Mondragon, Leonel
Richard, Silvina Mariel
Martinez Marignac, Veronica Lucrecia
author_role author
author2 Richard, Silvina Mariel
Martinez Marignac, Veronica Lucrecia
author2_role author
author
dc.subject.none.fl_str_mv MALARIA
CANCER
CROSS IMMUNE RESPONSE
ENDEMIC ZONE
SOUTH AMERICA
topic MALARIA
CANCER
CROSS IMMUNE RESPONSE
ENDEMIC ZONE
SOUTH AMERICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv An inverse association between malaria infection and risk of cancer has been established worldwide, however nutritional, economical incomes, social parameters bias and cancer risk increased by year related to life style and other factors have not been studied in an endemic malaria region such as those in South America. The present analysis examines the association by malaria and cancer and neoplasm incidence, restricting analyses to studies performed by the Institute for Health Metrics and Evaluation (IHME) where data for South America for endemic countries (Suriname, Guyana, Ecuador, Peru, Venezuela, Colombia, Brazil, Bolivia) and non malaria endemic countries were available (Argentina, Paraguay). Uruguay and Chile were included as outliers per more than 10 years with no reported cases of Malaria. The authors reviewed available databases through 30 years, examining both sexes, people of 25 year of age and olders, and analyzed the association between malaria, year of incidence, nutrition and risk of having different types of cancers and neoplasm as they were defined by Global Health Data Exchange (GHDx) and IHME. An inverse association between malaria total cancer and a strong negative correlation with neoplasm was found in both sexes. This study confirms previous studies reporting an inverse association between malaria and cancer and provides quantitative estimates of the inverse association in South American countries. We suggest that two malaria non-endemic countries (Chile and Uruguay) have an elevated risk level of cancer incidence. We discuss possible mechanism of malaria infection as an antagonist to cancer or neoplasm development.
Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina
Fil: Richard, Silvina Mariel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina
description An inverse association between malaria infection and risk of cancer has been established worldwide, however nutritional, economical incomes, social parameters bias and cancer risk increased by year related to life style and other factors have not been studied in an endemic malaria region such as those in South America. The present analysis examines the association by malaria and cancer and neoplasm incidence, restricting analyses to studies performed by the Institute for Health Metrics and Evaluation (IHME) where data for South America for endemic countries (Suriname, Guyana, Ecuador, Peru, Venezuela, Colombia, Brazil, Bolivia) and non malaria endemic countries were available (Argentina, Paraguay). Uruguay and Chile were included as outliers per more than 10 years with no reported cases of Malaria. The authors reviewed available databases through 30 years, examining both sexes, people of 25 year of age and olders, and analyzed the association between malaria, year of incidence, nutrition and risk of having different types of cancers and neoplasm as they were defined by Global Health Data Exchange (GHDx) and IHME. An inverse association between malaria total cancer and a strong negative correlation with neoplasm was found in both sexes. This study confirms previous studies reporting an inverse association between malaria and cancer and provides quantitative estimates of the inverse association in South American countries. We suggest that two malaria non-endemic countries (Chile and Uruguay) have an elevated risk level of cancer incidence. We discuss possible mechanism of malaria infection as an antagonist to cancer or neoplasm development.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256286
Mondragon, Leonel; Richard, Silvina Mariel; Martinez Marignac, Veronica Lucrecia; Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence; Vcare Clinic and Research Center; Journal of Medical Research and Health Sciences; 7; 2; 2-2024; 3004-3012
2589-9023
2589-9031
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256286
identifier_str_mv Mondragon, Leonel; Richard, Silvina Mariel; Martinez Marignac, Veronica Lucrecia; Relationship Between the Exposure of Malaria in an Endemic Zone and its Association with Cancer Incidence; Vcare Clinic and Research Center; Journal of Medical Research and Health Sciences; 7; 2; 2-2024; 3004-3012
2589-9023
2589-9031
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jmrhs.info/index.php/jmrhs/article/view/690
info:eu-repo/semantics/altIdentifier/doi/10.52845/JMRHS/2024-7-2-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Vcare Clinic and Research Center
publisher.none.fl_str_mv Vcare Clinic and Research Center
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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