Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery

Autores
Das, Amrita; Sengupta, Prateep; Chatterjee, Shreya; Khanam, Jasmina; Kumar Mondal, Pranab; Romero, Eder Lilia; Manakhov, Anton M.; Thomas, Sabu; Mahmood, Syed; Ghosal, Kajal
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences.
Fil: Das, Amrita. Jadavpur University; India
Fil: Sengupta, Prateep. Jadavpur University; India
Fil: Chatterjee, Shreya. Jadavpur University; India
Fil: Khanam, Jasmina. Jadavpur University; India
Fil: Kumar Mondal, Pranab. Jadavpur University; India. Indian Institute of Technology; India
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manakhov, Anton M.. National University of Science and Technology “MISIS”; Rusia. Research Institute of Clinical and Experimental Lymphology; Rusia
Fil: Thomas, Sabu. Mahatma Gandhi University; India
Fil: Mahmood, Syed. Universiti Malaya; Malasia
Fil: Ghosal, Kajal. Jadavpur University; India
Materia
MAGNETIC NANOPARTICLE
SODIUM ALGINATE
ACECLOFENAC
VIBRATING SAMPLE MAGNETOMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/276038
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/276038
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug DeliveryDas, AmritaSengupta, PrateepChatterjee, ShreyaKhanam, JasminaKumar Mondal, PranabRomero, Eder LiliaManakhov, Anton M.Thomas, SabuMahmood, SyedGhosal, KajalMAGNETIC NANOPARTICLESODIUM ALGINATEACECLOFENACVIBRATING SAMPLE MAGNETOMETRYhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences.Fil: Das, Amrita. Jadavpur University; IndiaFil: Sengupta, Prateep. Jadavpur University; IndiaFil: Chatterjee, Shreya. Jadavpur University; IndiaFil: Khanam, Jasmina. Jadavpur University; IndiaFil: Kumar Mondal, Pranab. Jadavpur University; India. Indian Institute of Technology; IndiaFil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Manakhov, Anton M.. National University of Science and Technology “MISIS”; Rusia. Research Institute of Clinical and Experimental Lymphology; RusiaFil: Thomas, Sabu. Mahatma Gandhi University; IndiaFil: Mahmood, Syed. Universiti Malaya; MalasiaFil: Ghosal, Kajal. Jadavpur University; IndiaMultidisciplinary Digital Publishing Institute2025-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/276038Das, Amrita; Sengupta, Prateep; Chatterjee, Shreya; Khanam, Jasmina; Kumar Mondal, Pranab; et al.; Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery; Multidisciplinary Digital Publishing Institute; Magnetochemistry; 11; 2; 2-2025; 1-212312-7481CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/ magnetochemistry11020014info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2312-7481/11/2/14info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T14:38:42Zoai:ri.conicet.gov.ar:11336/276038instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 14:38:43.26CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
title Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
spellingShingle Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
Das, Amrita
MAGNETIC NANOPARTICLE
SODIUM ALGINATE
ACECLOFENAC
VIBRATING SAMPLE MAGNETOMETRY
title_short Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
title_full Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
title_fullStr Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
title_full_unstemmed Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
title_sort Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
dc.creator.none.fl_str_mv Das, Amrita
Sengupta, Prateep
Chatterjee, Shreya
Khanam, Jasmina
Kumar Mondal, Pranab
Romero, Eder Lilia
Manakhov, Anton M.
Thomas, Sabu
Mahmood, Syed
Ghosal, Kajal
author Das, Amrita
author_facet Das, Amrita
Sengupta, Prateep
Chatterjee, Shreya
Khanam, Jasmina
Kumar Mondal, Pranab
Romero, Eder Lilia
Manakhov, Anton M.
Thomas, Sabu
Mahmood, Syed
Ghosal, Kajal
author_role author
author2 Sengupta, Prateep
Chatterjee, Shreya
Khanam, Jasmina
Kumar Mondal, Pranab
Romero, Eder Lilia
Manakhov, Anton M.
Thomas, Sabu
Mahmood, Syed
Ghosal, Kajal
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MAGNETIC NANOPARTICLE
SODIUM ALGINATE
ACECLOFENAC
VIBRATING SAMPLE MAGNETOMETRY
topic MAGNETIC NANOPARTICLE
SODIUM ALGINATE
ACECLOFENAC
VIBRATING SAMPLE MAGNETOMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences.
Fil: Das, Amrita. Jadavpur University; India
Fil: Sengupta, Prateep. Jadavpur University; India
Fil: Chatterjee, Shreya. Jadavpur University; India
Fil: Khanam, Jasmina. Jadavpur University; India
Fil: Kumar Mondal, Pranab. Jadavpur University; India. Indian Institute of Technology; India
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manakhov, Anton M.. National University of Science and Technology “MISIS”; Rusia. Research Institute of Clinical and Experimental Lymphology; Rusia
Fil: Thomas, Sabu. Mahatma Gandhi University; India
Fil: Mahmood, Syed. Universiti Malaya; Malasia
Fil: Ghosal, Kajal. Jadavpur University; India
description Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences.
publishDate 2025
dc.date.none.fl_str_mv 2025-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/276038
Das, Amrita; Sengupta, Prateep; Chatterjee, Shreya; Khanam, Jasmina; Kumar Mondal, Pranab; et al.; Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery; Multidisciplinary Digital Publishing Institute; Magnetochemistry; 11; 2; 2-2025; 1-21
2312-7481
CONICET Digital
CONICET
url http://hdl.handle.net/11336/276038
identifier_str_mv Das, Amrita; Sengupta, Prateep; Chatterjee, Shreya; Khanam, Jasmina; Kumar Mondal, Pranab; et al.; Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery; Multidisciplinary Digital Publishing Institute; Magnetochemistry; 11; 2; 2-2025; 1-21
2312-7481
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ magnetochemistry11020014
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2312-7481/11/2/14
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1852335764165099520
score 12.952241

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