Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity

Autores
Moritz, Maria Izabel G.; Marostica, Lucas Lourenço; Bianco, Éverson M.; Rojo de Almeida, Maria Tereza; Carraro, João L.; Cabrera, Gabriela Myriam; Palermo, Jorge Alejandro; Simoes, Cláudia M. O.; Schenkel, Eloir P.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.
Fil: Moritz, Maria Izabel G.. Universidade Federal de Santa Catarina; Brasil
Fil: Marostica, Lucas Lourenço. Universidade Federal de Santa Catarina; Brasil
Fil: Bianco, Éverson M.. Universidade Federal de Santa Catarina; Brasil
Fil: Rojo de Almeida, Maria Tereza. Universidade Federal de Santa Catarina; Brasil
Fil: Carraro, João L.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Palermo, Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Simoes, Cláudia M. O.. Universidade Federal de Santa Catarina; Brasil
Fil: Schenkel, Eloir P.. Universidade Federal de Santa Catarina; Brasil
Materia
CYTOTOXICITY
LEPTOGORGIA PUNICEA
OCTOCORALS
POLYOXYGENATED STEROIDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31458
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/31458
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic ActivityMoritz, Maria Izabel G.Marostica, Lucas LourençoBianco, Éverson M.Rojo de Almeida, Maria TerezaCarraro, João L.Cabrera, Gabriela MyriamPalermo, Jorge AlejandroSimoes, Cláudia M. O.Schenkel, Eloir P.CYTOTOXICITYLEPTOGORGIA PUNICEAOCTOCORALSPOLYOXYGENATED STEROIDShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.Fil: Moritz, Maria Izabel G.. Universidade Federal de Santa Catarina; BrasilFil: Marostica, Lucas Lourenço. Universidade Federal de Santa Catarina; BrasilFil: Bianco, Éverson M.. Universidade Federal de Santa Catarina; BrasilFil: Rojo de Almeida, Maria Tereza. Universidade Federal de Santa Catarina; BrasilFil: Carraro, João L.. Universidade Federal do Rio de Janeiro; BrasilFil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Palermo, Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Simoes, Cláudia M. O.. Universidade Federal de Santa Catarina; BrasilFil: Schenkel, Eloir P.. Universidade Federal de Santa Catarina; BrasilMolecular Diversity Preservation International2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31458Schenkel, Eloir P.; Simoes, Cláudia M. O.; Palermo, Jorge Alejandro; Cabrera, Gabriela Myriam; Carraro, João L.; Rojo de Almeida, Maria Tereza; et al.; Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity; Molecular Diversity Preservation International; Marine Drugs; 12; 12; 12-2014; 5864-58801660-3397CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/md12125864info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1660-3397/12/12/5864info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:24Zoai:ri.conicet.gov.ar:11336/31458instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:24.859CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
title Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
spellingShingle Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
Moritz, Maria Izabel G.
CYTOTOXICITY
LEPTOGORGIA PUNICEA
OCTOCORALS
POLYOXYGENATED STEROIDS
title_short Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
title_full Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
title_fullStr Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
title_full_unstemmed Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
title_sort Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity
dc.creator.none.fl_str_mv Moritz, Maria Izabel G.
Marostica, Lucas Lourenço
Bianco, Éverson M.
Rojo de Almeida, Maria Tereza
Carraro, João L.
Cabrera, Gabriela Myriam
Palermo, Jorge Alejandro
Simoes, Cláudia M. O.
Schenkel, Eloir P.
author Moritz, Maria Izabel G.
author_facet Moritz, Maria Izabel G.
Marostica, Lucas Lourenço
Bianco, Éverson M.
Rojo de Almeida, Maria Tereza
Carraro, João L.
Cabrera, Gabriela Myriam
Palermo, Jorge Alejandro
Simoes, Cláudia M. O.
Schenkel, Eloir P.
author_role author
author2 Marostica, Lucas Lourenço
Bianco, Éverson M.
Rojo de Almeida, Maria Tereza
Carraro, João L.
Cabrera, Gabriela Myriam
Palermo, Jorge Alejandro
Simoes, Cláudia M. O.
Schenkel, Eloir P.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CYTOTOXICITY
LEPTOGORGIA PUNICEA
OCTOCORALS
POLYOXYGENATED STEROIDS
topic CYTOTOXICITY
LEPTOGORGIA PUNICEA
OCTOCORALS
POLYOXYGENATED STEROIDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.
Fil: Moritz, Maria Izabel G.. Universidade Federal de Santa Catarina; Brasil
Fil: Marostica, Lucas Lourenço. Universidade Federal de Santa Catarina; Brasil
Fil: Bianco, Éverson M.. Universidade Federal de Santa Catarina; Brasil
Fil: Rojo de Almeida, Maria Tereza. Universidade Federal de Santa Catarina; Brasil
Fil: Carraro, João L.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Palermo, Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Simoes, Cláudia M. O.. Universidade Federal de Santa Catarina; Brasil
Fil: Schenkel, Eloir P.. Universidade Federal de Santa Catarina; Brasil
description Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31458
Schenkel, Eloir P.; Simoes, Cláudia M. O.; Palermo, Jorge Alejandro; Cabrera, Gabriela Myriam; Carraro, João L.; Rojo de Almeida, Maria Tereza; et al.; Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity; Molecular Diversity Preservation International; Marine Drugs; 12; 12; 12-2014; 5864-5880
1660-3397
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31458
identifier_str_mv Schenkel, Eloir P.; Simoes, Cláudia M. O.; Palermo, Jorge Alejandro; Cabrera, Gabriela Myriam; Carraro, João L.; Rojo de Almeida, Maria Tereza; et al.; Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity; Molecular Diversity Preservation International; Marine Drugs; 12; 12; 12-2014; 5864-5880
1660-3397
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/md12125864
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1660-3397/12/12/5864
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083312755408896
score 13.22299

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