Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon
- Autores
- Chapeletti da Silva, Cameron; Medanha Valdo, Ana K.; do Nascimento Neto, José Antonio; Ribeiro, Leandro Agustín; Sarotti, Ariel Marcelo; Martins Terra, Felipe
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Here we were interested in obtaining a better understanding of the competition between the salt heterosynthon and the base-pairing homosynthon formed by the anti-HIV drug lamivudine in the presence of strong acids. Even though the preparation of the multicomponent crystal forms of this drug with weak or moderate acids is well investigated, the crystallization of lamivudine with strong acids is still little explored. Besides filling this crystallization screening gap, the driving forces of the so-called lamivudine duplexes could be drawn from the complete structural landscape and the theoretical thermodynamic parameters of the salt heterosynthon, calculated at the M06-2X/6-31+G∗∗ level of theory. Five new crystal structures of lamivudine were obtained, wherein two of them were assembled as base-paired helically-stacked strands in the presence of trifluoroacetic and trichloroacetic acids (lamivudine duplexes V and VI, respectively). Besides, three salts were prepared by crystallization of lamivudine with sulfuric and perchloric acids. Finally, the theoretical approach showed that there is no energy trend regarding the formation of lamivudine duplexes with aliphatic organic acids or lamivudine salts with aromatic acids, which is usually observed in practice.
Fil: Chapeletti da Silva, Cameron. Universidade Federal de Goiás; Brasil
Fil: Medanha Valdo, Ana K.. Universidade Federal de Goiás; Brasil
Fil: do Nascimento Neto, José Antonio. Universidade Federal de Goiás; Brasil
Fil: Ribeiro, Leandro Agustín. Universidade Federal de Goiás; Brasil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Martins Terra, Felipe. Universidade Federal de Goiás; Brasil - Materia
-
LAMIVUDINE
HELICES
CRYSTALS
DFT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/87147
Ver los metadatos del registro completo
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Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthonChapeletti da Silva, CameronMedanha Valdo, Ana K.do Nascimento Neto, José AntonioRibeiro, Leandro AgustínSarotti, Ariel MarceloMartins Terra, FelipeLAMIVUDINEHELICESCRYSTALSDFThttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Here we were interested in obtaining a better understanding of the competition between the salt heterosynthon and the base-pairing homosynthon formed by the anti-HIV drug lamivudine in the presence of strong acids. Even though the preparation of the multicomponent crystal forms of this drug with weak or moderate acids is well investigated, the crystallization of lamivudine with strong acids is still little explored. Besides filling this crystallization screening gap, the driving forces of the so-called lamivudine duplexes could be drawn from the complete structural landscape and the theoretical thermodynamic parameters of the salt heterosynthon, calculated at the M06-2X/6-31+G∗∗ level of theory. Five new crystal structures of lamivudine were obtained, wherein two of them were assembled as base-paired helically-stacked strands in the presence of trifluoroacetic and trichloroacetic acids (lamivudine duplexes V and VI, respectively). Besides, three salts were prepared by crystallization of lamivudine with sulfuric and perchloric acids. Finally, the theoretical approach showed that there is no energy trend regarding the formation of lamivudine duplexes with aliphatic organic acids or lamivudine salts with aromatic acids, which is usually observed in practice.Fil: Chapeletti da Silva, Cameron. Universidade Federal de Goiás; BrasilFil: Medanha Valdo, Ana K.. Universidade Federal de Goiás; BrasilFil: do Nascimento Neto, José Antonio. Universidade Federal de Goiás; BrasilFil: Ribeiro, Leandro Agustín. Universidade Federal de Goiás; BrasilFil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Martins Terra, Felipe. Universidade Federal de Goiás; BrasilRoyal Society of Chemistry2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87147Chapeletti da Silva, Cameron; Medanha Valdo, Ana K.; do Nascimento Neto, José Antonio; Ribeiro, Leandro Agustín; Sarotti, Ariel Marcelo; et al.; Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon; Royal Society of Chemistry; CrystEngComm; 20; 22; 9-2018; 3049-30571466-8033CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c8ce00100finfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/CE/C8CE00100F#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:50Zoai:ri.conicet.gov.ar:11336/87147instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:51.082CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
title |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
spellingShingle |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon Chapeletti da Silva, Cameron LAMIVUDINE HELICES CRYSTALS DFT |
title_short |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
title_full |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
title_fullStr |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
title_full_unstemmed |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
title_sort |
Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon |
dc.creator.none.fl_str_mv |
Chapeletti da Silva, Cameron Medanha Valdo, Ana K. do Nascimento Neto, José Antonio Ribeiro, Leandro Agustín Sarotti, Ariel Marcelo Martins Terra, Felipe |
author |
Chapeletti da Silva, Cameron |
author_facet |
Chapeletti da Silva, Cameron Medanha Valdo, Ana K. do Nascimento Neto, José Antonio Ribeiro, Leandro Agustín Sarotti, Ariel Marcelo Martins Terra, Felipe |
author_role |
author |
author2 |
Medanha Valdo, Ana K. do Nascimento Neto, José Antonio Ribeiro, Leandro Agustín Sarotti, Ariel Marcelo Martins Terra, Felipe |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
LAMIVUDINE HELICES CRYSTALS DFT |
topic |
LAMIVUDINE HELICES CRYSTALS DFT |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Here we were interested in obtaining a better understanding of the competition between the salt heterosynthon and the base-pairing homosynthon formed by the anti-HIV drug lamivudine in the presence of strong acids. Even though the preparation of the multicomponent crystal forms of this drug with weak or moderate acids is well investigated, the crystallization of lamivudine with strong acids is still little explored. Besides filling this crystallization screening gap, the driving forces of the so-called lamivudine duplexes could be drawn from the complete structural landscape and the theoretical thermodynamic parameters of the salt heterosynthon, calculated at the M06-2X/6-31+G∗∗ level of theory. Five new crystal structures of lamivudine were obtained, wherein two of them were assembled as base-paired helically-stacked strands in the presence of trifluoroacetic and trichloroacetic acids (lamivudine duplexes V and VI, respectively). Besides, three salts were prepared by crystallization of lamivudine with sulfuric and perchloric acids. Finally, the theoretical approach showed that there is no energy trend regarding the formation of lamivudine duplexes with aliphatic organic acids or lamivudine salts with aromatic acids, which is usually observed in practice. Fil: Chapeletti da Silva, Cameron. Universidade Federal de Goiás; Brasil Fil: Medanha Valdo, Ana K.. Universidade Federal de Goiás; Brasil Fil: do Nascimento Neto, José Antonio. Universidade Federal de Goiás; Brasil Fil: Ribeiro, Leandro Agustín. Universidade Federal de Goiás; Brasil Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Martins Terra, Felipe. Universidade Federal de Goiás; Brasil |
description |
Here we were interested in obtaining a better understanding of the competition between the salt heterosynthon and the base-pairing homosynthon formed by the anti-HIV drug lamivudine in the presence of strong acids. Even though the preparation of the multicomponent crystal forms of this drug with weak or moderate acids is well investigated, the crystallization of lamivudine with strong acids is still little explored. Besides filling this crystallization screening gap, the driving forces of the so-called lamivudine duplexes could be drawn from the complete structural landscape and the theoretical thermodynamic parameters of the salt heterosynthon, calculated at the M06-2X/6-31+G∗∗ level of theory. Five new crystal structures of lamivudine were obtained, wherein two of them were assembled as base-paired helically-stacked strands in the presence of trifluoroacetic and trichloroacetic acids (lamivudine duplexes V and VI, respectively). Besides, three salts were prepared by crystallization of lamivudine with sulfuric and perchloric acids. Finally, the theoretical approach showed that there is no energy trend regarding the formation of lamivudine duplexes with aliphatic organic acids or lamivudine salts with aromatic acids, which is usually observed in practice. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/87147 Chapeletti da Silva, Cameron; Medanha Valdo, Ana K.; do Nascimento Neto, José Antonio; Ribeiro, Leandro Agustín; Sarotti, Ariel Marcelo; et al.; Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon; Royal Society of Chemistry; CrystEngComm; 20; 22; 9-2018; 3049-3057 1466-8033 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/87147 |
identifier_str_mv |
Chapeletti da Silva, Cameron; Medanha Valdo, Ana K.; do Nascimento Neto, José Antonio; Ribeiro, Leandro Agustín; Sarotti, Ariel Marcelo; et al.; Why lamivudine assembles into double-stranded helices in crystals: Salt heterosynthon: Versus base-pairing homosynthon; Royal Society of Chemistry; CrystEngComm; 20; 22; 9-2018; 3049-3057 1466-8033 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1039/c8ce00100f info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/CE/C8CE00100F#!divAbstract |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269057063059456 |
score |
13.13397 |