Candida albicans modulates murine and human Beta Defensin-1 during vaginitis

Autores
Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; Icely, Paula Alejandra; Castillo, Graciela del Valle; Azcurra, Ana Isabel; Abiega, Claudio Daniel; Riera, Fernando Oscar; Sotomayor, Claudia Elena
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches.
Fil: Miró, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Caeiro, Juan Pablo. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Vargas, Lara. Sanatorio Allende; Argentina
Fil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina
Fil: Azcurra, Ana Isabel. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina
Fil: Abiega, Claudio Daniel. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Riera, Fernando Oscar. Sanatorio Allende; Argentina
Fil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
ANTIMICROBIAL PEPTIDES
BETA-DEFENSIN
CANDIDA ALBICANS
CYTOKINES
FUNGAL IMMUNITY
HBD1
MBD1
VAGINITIS
VULVOVAGINAL CANDIDIASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184275

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oai_identifier_str oai:ri.conicet.gov.ar:11336/184275
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Candida albicans modulates murine and human Beta Defensin-1 during vaginitisMiró, María SoledadCaeiro, Juan PabloRodriguez, EmilseVargas, LaraVigezzi, CeciliaIcely, Paula AlejandraCastillo, Graciela del ValleAzcurra, Ana IsabelAbiega, Claudio DanielRiera, Fernando OscarSotomayor, Claudia ElenaANTIMICROBIAL PEPTIDESBETA-DEFENSINCANDIDA ALBICANSCYTOKINESFUNGAL IMMUNITYHBD1MBD1VAGINITISVULVOVAGINAL CANDIDIASIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches.Fil: Miró, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Caeiro, Juan Pablo. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Vargas, Lara. Sanatorio Allende; ArgentinaFil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología; ArgentinaFil: Azcurra, Ana Isabel. Universidad Nacional de Córdoba. Facultad de Odontología; ArgentinaFil: Abiega, Claudio Daniel. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Riera, Fernando Oscar. Sanatorio Allende; ArgentinaFil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaMDPI2021-12-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184275Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; et al.; Candida albicans modulates murine and human Beta Defensin-1 during vaginitis; MDPI; Journal of Fungi; 8; 1; 28-12-2021; 1-182309-608XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2309-608X/8/1/20info:eu-repo/semantics/altIdentifier/doi/10.3390/jof8010020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:02Zoai:ri.conicet.gov.ar:11336/184275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:03.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
title Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
spellingShingle Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
Miró, María Soledad
ANTIMICROBIAL PEPTIDES
BETA-DEFENSIN
CANDIDA ALBICANS
CYTOKINES
FUNGAL IMMUNITY
HBD1
MBD1
VAGINITIS
VULVOVAGINAL CANDIDIASIS
title_short Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
title_full Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
title_fullStr Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
title_full_unstemmed Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
title_sort Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
dc.creator.none.fl_str_mv Miró, María Soledad
Caeiro, Juan Pablo
Rodriguez, Emilse
Vargas, Lara
Vigezzi, Cecilia
Icely, Paula Alejandra
Castillo, Graciela del Valle
Azcurra, Ana Isabel
Abiega, Claudio Daniel
Riera, Fernando Oscar
Sotomayor, Claudia Elena
author Miró, María Soledad
author_facet Miró, María Soledad
Caeiro, Juan Pablo
Rodriguez, Emilse
Vargas, Lara
Vigezzi, Cecilia
Icely, Paula Alejandra
Castillo, Graciela del Valle
Azcurra, Ana Isabel
Abiega, Claudio Daniel
Riera, Fernando Oscar
Sotomayor, Claudia Elena
author_role author
author2 Caeiro, Juan Pablo
Rodriguez, Emilse
Vargas, Lara
Vigezzi, Cecilia
Icely, Paula Alejandra
Castillo, Graciela del Valle
Azcurra, Ana Isabel
Abiega, Claudio Daniel
Riera, Fernando Oscar
Sotomayor, Claudia Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIMICROBIAL PEPTIDES
BETA-DEFENSIN
CANDIDA ALBICANS
CYTOKINES
FUNGAL IMMUNITY
HBD1
MBD1
VAGINITIS
VULVOVAGINAL CANDIDIASIS
topic ANTIMICROBIAL PEPTIDES
BETA-DEFENSIN
CANDIDA ALBICANS
CYTOKINES
FUNGAL IMMUNITY
HBD1
MBD1
VAGINITIS
VULVOVAGINAL CANDIDIASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches.
Fil: Miró, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Caeiro, Juan Pablo. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Vargas, Lara. Sanatorio Allende; Argentina
Fil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina
Fil: Azcurra, Ana Isabel. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina
Fil: Abiega, Claudio Daniel. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Riera, Fernando Oscar. Sanatorio Allende; Argentina
Fil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184275
Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; et al.; Candida albicans modulates murine and human Beta Defensin-1 during vaginitis; MDPI; Journal of Fungi; 8; 1; 28-12-2021; 1-18
2309-608X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184275
identifier_str_mv Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; et al.; Candida albicans modulates murine and human Beta Defensin-1 during vaginitis; MDPI; Journal of Fungi; 8; 1; 28-12-2021; 1-18
2309-608X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2309-608X/8/1/20
info:eu-repo/semantics/altIdentifier/doi/10.3390/jof8010020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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