Candida albicans modulates murine and human Beta Defensin-1 during vaginitis
- Autores
- Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; Icely, Paula Alejandra; Castillo, Graciela del Valle; Azcurra, Ana Isabel; Abiega, Claudio Daniel; Riera, Fernando Oscar; Sotomayor, Claudia Elena
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches.
Fil: Miró, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Caeiro, Juan Pablo. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Vargas, Lara. Sanatorio Allende; Argentina
Fil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina
Fil: Azcurra, Ana Isabel. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina
Fil: Abiega, Claudio Daniel. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Riera, Fernando Oscar. Sanatorio Allende; Argentina
Fil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina - Materia
-
ANTIMICROBIAL PEPTIDES
BETA-DEFENSIN
CANDIDA ALBICANS
CYTOKINES
FUNGAL IMMUNITY
HBD1
MBD1
VAGINITIS
VULVOVAGINAL CANDIDIASIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/184275
Ver los metadatos del registro completo
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Candida albicans modulates murine and human Beta Defensin-1 during vaginitisMiró, María SoledadCaeiro, Juan PabloRodriguez, EmilseVargas, LaraVigezzi, CeciliaIcely, Paula AlejandraCastillo, Graciela del ValleAzcurra, Ana IsabelAbiega, Claudio DanielRiera, Fernando OscarSotomayor, Claudia ElenaANTIMICROBIAL PEPTIDESBETA-DEFENSINCANDIDA ALBICANSCYTOKINESFUNGAL IMMUNITYHBD1MBD1VAGINITISVULVOVAGINAL CANDIDIASIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches.Fil: Miró, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Caeiro, Juan Pablo. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Vargas, Lara. Sanatorio Allende; ArgentinaFil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología; ArgentinaFil: Azcurra, Ana Isabel. Universidad Nacional de Córdoba. Facultad de Odontología; ArgentinaFil: Abiega, Claudio Daniel. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Riera, Fernando Oscar. Sanatorio Allende; ArgentinaFil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaMDPI2021-12-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184275Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; et al.; Candida albicans modulates murine and human Beta Defensin-1 during vaginitis; MDPI; Journal of Fungi; 8; 1; 28-12-2021; 1-182309-608XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2309-608X/8/1/20info:eu-repo/semantics/altIdentifier/doi/10.3390/jof8010020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:02Zoai:ri.conicet.gov.ar:11336/184275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:03.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
title |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
spellingShingle |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis Miró, María Soledad ANTIMICROBIAL PEPTIDES BETA-DEFENSIN CANDIDA ALBICANS CYTOKINES FUNGAL IMMUNITY HBD1 MBD1 VAGINITIS VULVOVAGINAL CANDIDIASIS |
title_short |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
title_full |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
title_fullStr |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
title_full_unstemmed |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
title_sort |
Candida albicans modulates murine and human Beta Defensin-1 during vaginitis |
dc.creator.none.fl_str_mv |
Miró, María Soledad Caeiro, Juan Pablo Rodriguez, Emilse Vargas, Lara Vigezzi, Cecilia Icely, Paula Alejandra Castillo, Graciela del Valle Azcurra, Ana Isabel Abiega, Claudio Daniel Riera, Fernando Oscar Sotomayor, Claudia Elena |
author |
Miró, María Soledad |
author_facet |
Miró, María Soledad Caeiro, Juan Pablo Rodriguez, Emilse Vargas, Lara Vigezzi, Cecilia Icely, Paula Alejandra Castillo, Graciela del Valle Azcurra, Ana Isabel Abiega, Claudio Daniel Riera, Fernando Oscar Sotomayor, Claudia Elena |
author_role |
author |
author2 |
Caeiro, Juan Pablo Rodriguez, Emilse Vargas, Lara Vigezzi, Cecilia Icely, Paula Alejandra Castillo, Graciela del Valle Azcurra, Ana Isabel Abiega, Claudio Daniel Riera, Fernando Oscar Sotomayor, Claudia Elena |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ANTIMICROBIAL PEPTIDES BETA-DEFENSIN CANDIDA ALBICANS CYTOKINES FUNGAL IMMUNITY HBD1 MBD1 VAGINITIS VULVOVAGINAL CANDIDIASIS |
topic |
ANTIMICROBIAL PEPTIDES BETA-DEFENSIN CANDIDA ALBICANS CYTOKINES FUNGAL IMMUNITY HBD1 MBD1 VAGINITIS VULVOVAGINAL CANDIDIASIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches. Fil: Miró, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Caeiro, Juan Pablo. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Vargas, Lara. Sanatorio Allende; Argentina Fil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Castillo, Graciela del Valle. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina Fil: Azcurra, Ana Isabel. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina Fil: Abiega, Claudio Daniel. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Riera, Fernando Oscar. Sanatorio Allende; Argentina Fil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina |
description |
Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-28 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/184275 Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; et al.; Candida albicans modulates murine and human Beta Defensin-1 during vaginitis; MDPI; Journal of Fungi; 8; 1; 28-12-2021; 1-18 2309-608X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/184275 |
identifier_str_mv |
Miró, María Soledad; Caeiro, Juan Pablo; Rodriguez, Emilse; Vargas, Lara; Vigezzi, Cecilia; et al.; Candida albicans modulates murine and human Beta Defensin-1 during vaginitis; MDPI; Journal of Fungi; 8; 1; 28-12-2021; 1-18 2309-608X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2309-608X/8/1/20 info:eu-repo/semantics/altIdentifier/doi/10.3390/jof8010020 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613298470780928 |
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13.070432 |