Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis

• Autores: Sookoian, Silvia Cristina; Pirola, Carlos José
• Año de publicación: 2016
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Nafld; Genetics; Metabolic Syndrome; Networks; Twin Study
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

A growing body of evidence indicates that nonalcoholic fatty liver disease (NAFLD) develops from a complex process that includes genetic susceptibility and environmental exposure. Regardless of whether it is the cause or the consequence of the metabolic syndrome (MetS), NAFLD often co-occurs with one or more MetS-associated phenotypes. There is also robust evidence in support of NAFLD and MetS sharing common pathogenic mechanisms.(1) Nevertheless, with the exception of the transmembrane 6 superfamily member 2 gene(2)— which illustrates an unexpected opposite association between NAFLD and cardiovascular disease, although it can be suspected—no compelling report demonstrating that NAFLD and MetS share a common genetic background presently exists. In this issue, Cui et al. show not only that steatosis and fibrosis potentially share the same predisposing genes but also that these conditions have a significant shared gene effect with metabolic risk factors,(3) the latter being a truly remarkable finding. These interesting results prompt several reflections.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina