Salmonella Typhimurium general virulence factors: a battle of David against Goliath?

Autores
Lopez, Fabian Enrique; Pescaretti, María de Las Mercedes; Morero, Roberto Dionisio; Delgado, Monica Alejandra
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The genus Salmonella is the most common agent causative of foodborne diseases. Although genus Salmonella members are genetically close microorganisms, they show wide variations in host-specificity, virulence and disease manifestations. Salmonellosis caused by contaminated water or food is usually present as two clinical forms: typhoid fever and nontyphoidal diseases. The latter producing gastroenteritis is frequently caused by Salmonella Typhimurium and Salmonella Enteritidis. The nontyphoidal S. Typhimurium infection involves the following steps: bacterial adhesion, invasion, SCV maturation and replication. During these steps there is a strong interaction between host and pathogen, in which the pathogen must resist different host defense mechanisms. In each of these stages the bacteria modulate the expression of diverse groups of genes, most of which are encoded in Salmonella pathogenicity islands (SPI). This modulation is in general under control of the so-called two-component systems (TCS). The TCSs are capable of sensing different environmental conditions and trigger a physiological response. Currently, the risk of contracting salmonellosis disease has been considerably increased due to the emergence of new serovars showing multiple-drug resistance that presents a high risk to human health. In this work, we summarize the new advances in the study of host-pathogen interactions during the Salmonella infection that leads to the establishment of the disease. This finding highlights the role of the S. Typhimurium secretion systems and effectors during infection. In addition, we mentioned some strategies that could be explored in order to take control of Salmonella infections. © 2011 Elsevier Ltd.
Fil: Lopez, Fabian Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Fil: Pescaretti, María de Las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Fil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Fil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Materia
Host-Interaction
Salmonella Typhimurium
Spi
Tcs
Virulence
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/60893
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/60893
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Salmonella Typhimurium general virulence factors: a battle of David against Goliath?Lopez, Fabian EnriquePescaretti, María de Las MercedesMorero, Roberto DionisioDelgado, Monica AlejandraHost-InteractionSalmonella TyphimuriumSpiTcsVirulencehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The genus Salmonella is the most common agent causative of foodborne diseases. Although genus Salmonella members are genetically close microorganisms, they show wide variations in host-specificity, virulence and disease manifestations. Salmonellosis caused by contaminated water or food is usually present as two clinical forms: typhoid fever and nontyphoidal diseases. The latter producing gastroenteritis is frequently caused by Salmonella Typhimurium and Salmonella Enteritidis. The nontyphoidal S. Typhimurium infection involves the following steps: bacterial adhesion, invasion, SCV maturation and replication. During these steps there is a strong interaction between host and pathogen, in which the pathogen must resist different host defense mechanisms. In each of these stages the bacteria modulate the expression of diverse groups of genes, most of which are encoded in Salmonella pathogenicity islands (SPI). This modulation is in general under control of the so-called two-component systems (TCS). The TCSs are capable of sensing different environmental conditions and trigger a physiological response. Currently, the risk of contracting salmonellosis disease has been considerably increased due to the emergence of new serovars showing multiple-drug resistance that presents a high risk to human health. In this work, we summarize the new advances in the study of host-pathogen interactions during the Salmonella infection that leads to the establishment of the disease. This finding highlights the role of the S. Typhimurium secretion systems and effectors during infection. In addition, we mentioned some strategies that could be explored in order to take control of Salmonella infections. © 2011 Elsevier Ltd.Fil: Lopez, Fabian Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; ArgentinaFil: Pescaretti, María de Las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; ArgentinaFil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; ArgentinaFil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; ArgentinaElsevier Science2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/60893Lopez, Fabian Enrique; Pescaretti, María de Las Mercedes; Morero, Roberto Dionisio; Delgado, Monica Alejandra; Salmonella Typhimurium general virulence factors: a battle of David against Goliath?; Elsevier Science; Food Research International; 45; 2; 3-2012; 842-8510963-9969CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2011.08.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0963996911005035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:44Zoai:ri.conicet.gov.ar:11336/60893instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:45.176CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
title Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
spellingShingle Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
Lopez, Fabian Enrique
Host-Interaction
Salmonella Typhimurium
Spi
Tcs
Virulence
title_short Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
title_full Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
title_fullStr Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
title_full_unstemmed Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
title_sort Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
dc.creator.none.fl_str_mv Lopez, Fabian Enrique
Pescaretti, María de Las Mercedes
Morero, Roberto Dionisio
Delgado, Monica Alejandra
author Lopez, Fabian Enrique
author_facet Lopez, Fabian Enrique
Pescaretti, María de Las Mercedes
Morero, Roberto Dionisio
Delgado, Monica Alejandra
author_role author
author2 Pescaretti, María de Las Mercedes
Morero, Roberto Dionisio
Delgado, Monica Alejandra
author2_role author
author
author
dc.subject.none.fl_str_mv Host-Interaction
Salmonella Typhimurium
Spi
Tcs
Virulence
topic Host-Interaction
Salmonella Typhimurium
Spi
Tcs
Virulence
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The genus Salmonella is the most common agent causative of foodborne diseases. Although genus Salmonella members are genetically close microorganisms, they show wide variations in host-specificity, virulence and disease manifestations. Salmonellosis caused by contaminated water or food is usually present as two clinical forms: typhoid fever and nontyphoidal diseases. The latter producing gastroenteritis is frequently caused by Salmonella Typhimurium and Salmonella Enteritidis. The nontyphoidal S. Typhimurium infection involves the following steps: bacterial adhesion, invasion, SCV maturation and replication. During these steps there is a strong interaction between host and pathogen, in which the pathogen must resist different host defense mechanisms. In each of these stages the bacteria modulate the expression of diverse groups of genes, most of which are encoded in Salmonella pathogenicity islands (SPI). This modulation is in general under control of the so-called two-component systems (TCS). The TCSs are capable of sensing different environmental conditions and trigger a physiological response. Currently, the risk of contracting salmonellosis disease has been considerably increased due to the emergence of new serovars showing multiple-drug resistance that presents a high risk to human health. In this work, we summarize the new advances in the study of host-pathogen interactions during the Salmonella infection that leads to the establishment of the disease. This finding highlights the role of the S. Typhimurium secretion systems and effectors during infection. In addition, we mentioned some strategies that could be explored in order to take control of Salmonella infections. © 2011 Elsevier Ltd.
Fil: Lopez, Fabian Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Fil: Pescaretti, María de Las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Fil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
Fil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Bioquímica de la Nutrición; Argentina. Instituto de Química Biologica “Dr. Bernabe Bloj”; Argentina
description The genus Salmonella is the most common agent causative of foodborne diseases. Although genus Salmonella members are genetically close microorganisms, they show wide variations in host-specificity, virulence and disease manifestations. Salmonellosis caused by contaminated water or food is usually present as two clinical forms: typhoid fever and nontyphoidal diseases. The latter producing gastroenteritis is frequently caused by Salmonella Typhimurium and Salmonella Enteritidis. The nontyphoidal S. Typhimurium infection involves the following steps: bacterial adhesion, invasion, SCV maturation and replication. During these steps there is a strong interaction between host and pathogen, in which the pathogen must resist different host defense mechanisms. In each of these stages the bacteria modulate the expression of diverse groups of genes, most of which are encoded in Salmonella pathogenicity islands (SPI). This modulation is in general under control of the so-called two-component systems (TCS). The TCSs are capable of sensing different environmental conditions and trigger a physiological response. Currently, the risk of contracting salmonellosis disease has been considerably increased due to the emergence of new serovars showing multiple-drug resistance that presents a high risk to human health. In this work, we summarize the new advances in the study of host-pathogen interactions during the Salmonella infection that leads to the establishment of the disease. This finding highlights the role of the S. Typhimurium secretion systems and effectors during infection. In addition, we mentioned some strategies that could be explored in order to take control of Salmonella infections. © 2011 Elsevier Ltd.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/60893
Lopez, Fabian Enrique; Pescaretti, María de Las Mercedes; Morero, Roberto Dionisio; Delgado, Monica Alejandra; Salmonella Typhimurium general virulence factors: a battle of David against Goliath?; Elsevier Science; Food Research International; 45; 2; 3-2012; 842-851
0963-9969
CONICET Digital
CONICET
url http://hdl.handle.net/11336/60893
identifier_str_mv Lopez, Fabian Enrique; Pescaretti, María de Las Mercedes; Morero, Roberto Dionisio; Delgado, Monica Alejandra; Salmonella Typhimurium general virulence factors: a battle of David against Goliath?; Elsevier Science; Food Research International; 45; 2; 3-2012; 842-851
0963-9969
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2011.08.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0963996911005035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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