Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers

Autores
Fanani, Maria Laura; Maggio, Bruno
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work describes how changes in surface pressure modulate the molecular organization of Langmuir monolayers formed by ternary mixtures of dlPC/pSM/Dchol that exhibit coexistence of liquid-expanded (LE) and liquid-ordered (Lo) phases. It provides a theoretical framework for understanding the pressure-induced critical miscibility point characteristic of monolayer systems with liquid-liquid phase coexistence. From compression isotherms and Brewster Angle Microscopy of Langmuir monolayers with a composition close to a tie line, we determined experimental values of mean molecular areas, surface potential, monolayer thickness, and could estimate the mean molecular area and composition of each coexisting phase. A surface pressure-induced enrichment of the PC component in the Lo phase reduces both the compositional miscibility gap and the hydrophobic mismatch between phases. The liquid-liquid miscibility transition point observed at ¡Ö25mN/m can be explained by a competition between thermal energy and the line tension arising from the hydrophobic mismatch between the coexisting liquid phases.
Fil: Fanani, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Maggio, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Materia
Liquid ordered phase
Brewster Angle Microscopy
Cholesterol-rich domains
Ternary lipid interface
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/230261
Acceder
id CONICETDig_60142936dbda253d34aa00eed5f04110
oai_identifier_str oai:ri.conicet.gov.ar:11336/230261
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayersFanani, Maria LauraMaggio, BrunoLiquid ordered phaseBrewster Angle MicroscopyCholesterol-rich domainsTernary lipid interfacehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This work describes how changes in surface pressure modulate the molecular organization of Langmuir monolayers formed by ternary mixtures of dlPC/pSM/Dchol that exhibit coexistence of liquid-expanded (LE) and liquid-ordered (Lo) phases. It provides a theoretical framework for understanding the pressure-induced critical miscibility point characteristic of monolayer systems with liquid-liquid phase coexistence. From compression isotherms and Brewster Angle Microscopy of Langmuir monolayers with a composition close to a tie line, we determined experimental values of mean molecular areas, surface potential, monolayer thickness, and could estimate the mean molecular area and composition of each coexisting phase. A surface pressure-induced enrichment of the PC component in the Lo phase reduces both the compositional miscibility gap and the hydrophobic mismatch between phases. The liquid-liquid miscibility transition point observed at ¡Ö25mN/m can be explained by a competition between thermal energy and the line tension arising from the hydrophobic mismatch between the coexisting liquid phases.Fil: Fanani, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Maggio, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaAmerican Chemical Society2010-12-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230261Fanani, Maria Laura; Maggio, Bruno; Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers; American Chemical Society; Journal of Physical Chemistry B; 115; 1; 10-12-2010; 41-491520-61061520-5207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/jp107344tinfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/jp107344tinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:35:26Zoai:ri.conicet.gov.ar:11336/230261instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:35:26.447CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
title Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
spellingShingle Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
Fanani, Maria Laura
Liquid ordered phase
Brewster Angle Microscopy
Cholesterol-rich domains
Ternary lipid interface
title_short Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
title_full Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
title_fullStr Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
title_full_unstemmed Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
title_sort Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers
dc.creator.none.fl_str_mv Fanani, Maria Laura
Maggio, Bruno
author Fanani, Maria Laura
author_facet Fanani, Maria Laura
Maggio, Bruno
author_role author
author2 Maggio, Bruno
author2_role author
dc.subject.none.fl_str_mv Liquid ordered phase
Brewster Angle Microscopy
Cholesterol-rich domains
Ternary lipid interface
topic Liquid ordered phase
Brewster Angle Microscopy
Cholesterol-rich domains
Ternary lipid interface
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work describes how changes in surface pressure modulate the molecular organization of Langmuir monolayers formed by ternary mixtures of dlPC/pSM/Dchol that exhibit coexistence of liquid-expanded (LE) and liquid-ordered (Lo) phases. It provides a theoretical framework for understanding the pressure-induced critical miscibility point characteristic of monolayer systems with liquid-liquid phase coexistence. From compression isotherms and Brewster Angle Microscopy of Langmuir monolayers with a composition close to a tie line, we determined experimental values of mean molecular areas, surface potential, monolayer thickness, and could estimate the mean molecular area and composition of each coexisting phase. A surface pressure-induced enrichment of the PC component in the Lo phase reduces both the compositional miscibility gap and the hydrophobic mismatch between phases. The liquid-liquid miscibility transition point observed at ¡Ö25mN/m can be explained by a competition between thermal energy and the line tension arising from the hydrophobic mismatch between the coexisting liquid phases.
Fil: Fanani, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Maggio, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
description This work describes how changes in surface pressure modulate the molecular organization of Langmuir monolayers formed by ternary mixtures of dlPC/pSM/Dchol that exhibit coexistence of liquid-expanded (LE) and liquid-ordered (Lo) phases. It provides a theoretical framework for understanding the pressure-induced critical miscibility point characteristic of monolayer systems with liquid-liquid phase coexistence. From compression isotherms and Brewster Angle Microscopy of Langmuir monolayers with a composition close to a tie line, we determined experimental values of mean molecular areas, surface potential, monolayer thickness, and could estimate the mean molecular area and composition of each coexisting phase. A surface pressure-induced enrichment of the PC component in the Lo phase reduces both the compositional miscibility gap and the hydrophobic mismatch between phases. The liquid-liquid miscibility transition point observed at ¡Ö25mN/m can be explained by a competition between thermal energy and the line tension arising from the hydrophobic mismatch between the coexisting liquid phases.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/230261
Fanani, Maria Laura; Maggio, Bruno; Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers; American Chemical Society; Journal of Physical Chemistry B; 115; 1; 10-12-2010; 41-49
1520-6106
1520-5207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/230261
identifier_str_mv Fanani, Maria Laura; Maggio, Bruno; Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers; American Chemical Society; Journal of Physical Chemistry B; 115; 1; 10-12-2010; 41-49
1520-6106
1520-5207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/jp107344t
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/jp107344t
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848597191418970112
score 12.976206

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