Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions

Autores
Delpino, María Victoria; Quarleri, Jorge Fabian
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hepatitis B virus (HBV) infection poses a global health concern without adefinitive cure; however, antiviral medications can effectively suppress viralreplication. This study delves into the intricate interplay between lipid metabolism and HBV replication, implicating molecular mechanisms such as the stearoylcoenzyme A desaturase 1 autophagy pathway, SAC1-like phosphatidylinositolphosphatase, and galectin-9 mediated selective autophagy of viral core proteins inregulating HBV replication. Within lipid droplets, perilipin 2 (PLIN2) emerges asa pivotal guardian, with its overexpression protecting against autophagy anddownregulation stimulating triglyceride catabolism through the autophagypathway. This editorial discusses the correlation between hepatic steatosis andHBV replication, emphasizing the role of PLIN2 in this process. The studyunderscores the multifaceted roles of lipid metabolism, autophagy, and perilipinsin HBV replication, shedding light on potential therapeutic avenues.
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
LIVER
HBV
HEPATITIS B VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266780
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditionsDelpino, María VictoriaQuarleri, Jorge FabianLIVERHBVHEPATITIS B VIRUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hepatitis B virus (HBV) infection poses a global health concern without adefinitive cure; however, antiviral medications can effectively suppress viralreplication. This study delves into the intricate interplay between lipid metabolism and HBV replication, implicating molecular mechanisms such as the stearoylcoenzyme A desaturase 1 autophagy pathway, SAC1-like phosphatidylinositolphosphatase, and galectin-9 mediated selective autophagy of viral core proteins inregulating HBV replication. Within lipid droplets, perilipin 2 (PLIN2) emerges asa pivotal guardian, with its overexpression protecting against autophagy anddownregulation stimulating triglyceride catabolism through the autophagypathway. This editorial discusses the correlation between hepatic steatosis andHBV replication, emphasizing the role of PLIN2 in this process. The studyunderscores the multifaceted roles of lipid metabolism, autophagy, and perilipinsin HBV replication, shedding light on potential therapeutic avenues.Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaBaishideng Publishing Group2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266780Delpino, María Victoria; Quarleri, Jorge Fabian; Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions; Baishideng Publishing Group; World Journal of Virology; 13; 1; 3-2024; 1-52220-3249CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2220-3249/full/v13/i1/90384.htminfo:eu-repo/semantics/altIdentifier/doi/10.5501/wjv.v13.i1.90384info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:58Zoai:ri.conicet.gov.ar:11336/266780instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:59.218CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
title Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
spellingShingle Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
Delpino, María Victoria
LIVER
HBV
HEPATITIS B VIRUS
title_short Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
title_full Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
title_fullStr Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
title_full_unstemmed Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
title_sort Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions
dc.creator.none.fl_str_mv Delpino, María Victoria
Quarleri, Jorge Fabian
author Delpino, María Victoria
author_facet Delpino, María Victoria
Quarleri, Jorge Fabian
author_role author
author2 Quarleri, Jorge Fabian
author2_role author
dc.subject.none.fl_str_mv LIVER
HBV
HEPATITIS B VIRUS
topic LIVER
HBV
HEPATITIS B VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hepatitis B virus (HBV) infection poses a global health concern without adefinitive cure; however, antiviral medications can effectively suppress viralreplication. This study delves into the intricate interplay between lipid metabolism and HBV replication, implicating molecular mechanisms such as the stearoylcoenzyme A desaturase 1 autophagy pathway, SAC1-like phosphatidylinositolphosphatase, and galectin-9 mediated selective autophagy of viral core proteins inregulating HBV replication. Within lipid droplets, perilipin 2 (PLIN2) emerges asa pivotal guardian, with its overexpression protecting against autophagy anddownregulation stimulating triglyceride catabolism through the autophagypathway. This editorial discusses the correlation between hepatic steatosis andHBV replication, emphasizing the role of PLIN2 in this process. The studyunderscores the multifaceted roles of lipid metabolism, autophagy, and perilipinsin HBV replication, shedding light on potential therapeutic avenues.
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Hepatitis B virus (HBV) infection poses a global health concern without adefinitive cure; however, antiviral medications can effectively suppress viralreplication. This study delves into the intricate interplay between lipid metabolism and HBV replication, implicating molecular mechanisms such as the stearoylcoenzyme A desaturase 1 autophagy pathway, SAC1-like phosphatidylinositolphosphatase, and galectin-9 mediated selective autophagy of viral core proteins inregulating HBV replication. Within lipid droplets, perilipin 2 (PLIN2) emerges asa pivotal guardian, with its overexpression protecting against autophagy anddownregulation stimulating triglyceride catabolism through the autophagypathway. This editorial discusses the correlation between hepatic steatosis andHBV replication, emphasizing the role of PLIN2 in this process. The studyunderscores the multifaceted roles of lipid metabolism, autophagy, and perilipinsin HBV replication, shedding light on potential therapeutic avenues.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266780
Delpino, María Victoria; Quarleri, Jorge Fabian; Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions; Baishideng Publishing Group; World Journal of Virology; 13; 1; 3-2024; 1-5
2220-3249
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266780
identifier_str_mv Delpino, María Victoria; Quarleri, Jorge Fabian; Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions; Baishideng Publishing Group; World Journal of Virology; 13; 1; 3-2024; 1-5
2220-3249
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2220-3249/full/v13/i1/90384.htm
info:eu-repo/semantics/altIdentifier/doi/10.5501/wjv.v13.i1.90384
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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