Deracemisation processes employing organocatalysis and enzyme catalysis

Autores
Aranda Álvarez, María del Carmen; Oksdath Mansilla, Gabriela; Bisogno, Fabricio Román; de Gonzalo, Gonzalo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can be converted to the other through a deracemisation procedure, that can be achieved by different mechanisms based on stereoinversion or enantioconvergence, often involving two-opposite half reactions, with at least one of the reactions being enantioselective enough to finally obtain an enantioenriched chiral compound. The focus of this comprehensive review is on the application of deracemisation procedures in the present century in order to obtain optically active valuable compounds when employing non-metallic catalysts. Thus, the review will mainly focus on the use of different enzymatic preparations (purified enzymes, cell-free extracts or whole cell systems) and organocatalysts for the deracemisation of racemic mixtures. (Figure presented.).
Fil: Aranda Álvarez, María del Carmen. Instituto de Recursos Naturales y Agrobiologia de Sevilla; España
Fil: Oksdath Mansilla, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Bisogno, Fabricio Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: de Gonzalo, Gonzalo. Universidad de Sevilla; España
Materia
BIOCATALYSIS
CHIRAL AMINES
DERACEMISATION
ENANTIOSELECTIVITY
ORGANOCATALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/142568
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Deracemisation processes employing organocatalysis and enzyme catalysisAranda Álvarez, María del CarmenOksdath Mansilla, GabrielaBisogno, Fabricio Románde Gonzalo, GonzaloBIOCATALYSISCHIRAL AMINESDERACEMISATIONENANTIOSELECTIVITYORGANOCATALYSIShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can be converted to the other through a deracemisation procedure, that can be achieved by different mechanisms based on stereoinversion or enantioconvergence, often involving two-opposite half reactions, with at least one of the reactions being enantioselective enough to finally obtain an enantioenriched chiral compound. The focus of this comprehensive review is on the application of deracemisation procedures in the present century in order to obtain optically active valuable compounds when employing non-metallic catalysts. Thus, the review will mainly focus on the use of different enzymatic preparations (purified enzymes, cell-free extracts or whole cell systems) and organocatalysts for the deracemisation of racemic mixtures. (Figure presented.).Fil: Aranda Álvarez, María del Carmen. Instituto de Recursos Naturales y Agrobiologia de Sevilla; EspañaFil: Oksdath Mansilla, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Bisogno, Fabricio Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: de Gonzalo, Gonzalo. Universidad de Sevilla; EspañaWiley VCH Verlag2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142568Aranda Álvarez, María del Carmen; Oksdath Mansilla, Gabriela; Bisogno, Fabricio Román; de Gonzalo, Gonzalo; Deracemisation processes employing organocatalysis and enzyme catalysis; Wiley VCH Verlag; Advanced Synthesis & Catalysis (print); 362; 6; 3-2020; 1233-12571615-41501615-4169CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/adsc.201901112info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:57Zoai:ri.conicet.gov.ar:11336/142568instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:57.683CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deracemisation processes employing organocatalysis and enzyme catalysis
title Deracemisation processes employing organocatalysis and enzyme catalysis
spellingShingle Deracemisation processes employing organocatalysis and enzyme catalysis
Aranda Álvarez, María del Carmen
BIOCATALYSIS
CHIRAL AMINES
DERACEMISATION
ENANTIOSELECTIVITY
ORGANOCATALYSIS
title_short Deracemisation processes employing organocatalysis and enzyme catalysis
title_full Deracemisation processes employing organocatalysis and enzyme catalysis
title_fullStr Deracemisation processes employing organocatalysis and enzyme catalysis
title_full_unstemmed Deracemisation processes employing organocatalysis and enzyme catalysis
title_sort Deracemisation processes employing organocatalysis and enzyme catalysis
dc.creator.none.fl_str_mv Aranda Álvarez, María del Carmen
Oksdath Mansilla, Gabriela
Bisogno, Fabricio Román
de Gonzalo, Gonzalo
author Aranda Álvarez, María del Carmen
author_facet Aranda Álvarez, María del Carmen
Oksdath Mansilla, Gabriela
Bisogno, Fabricio Román
de Gonzalo, Gonzalo
author_role author
author2 Oksdath Mansilla, Gabriela
Bisogno, Fabricio Román
de Gonzalo, Gonzalo
author2_role author
author
author
dc.subject.none.fl_str_mv BIOCATALYSIS
CHIRAL AMINES
DERACEMISATION
ENANTIOSELECTIVITY
ORGANOCATALYSIS
topic BIOCATALYSIS
CHIRAL AMINES
DERACEMISATION
ENANTIOSELECTIVITY
ORGANOCATALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can be converted to the other through a deracemisation procedure, that can be achieved by different mechanisms based on stereoinversion or enantioconvergence, often involving two-opposite half reactions, with at least one of the reactions being enantioselective enough to finally obtain an enantioenriched chiral compound. The focus of this comprehensive review is on the application of deracemisation procedures in the present century in order to obtain optically active valuable compounds when employing non-metallic catalysts. Thus, the review will mainly focus on the use of different enzymatic preparations (purified enzymes, cell-free extracts or whole cell systems) and organocatalysts for the deracemisation of racemic mixtures. (Figure presented.).
Fil: Aranda Álvarez, María del Carmen. Instituto de Recursos Naturales y Agrobiologia de Sevilla; España
Fil: Oksdath Mansilla, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Bisogno, Fabricio Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: de Gonzalo, Gonzalo. Universidad de Sevilla; España
description Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can be converted to the other through a deracemisation procedure, that can be achieved by different mechanisms based on stereoinversion or enantioconvergence, often involving two-opposite half reactions, with at least one of the reactions being enantioselective enough to finally obtain an enantioenriched chiral compound. The focus of this comprehensive review is on the application of deracemisation procedures in the present century in order to obtain optically active valuable compounds when employing non-metallic catalysts. Thus, the review will mainly focus on the use of different enzymatic preparations (purified enzymes, cell-free extracts or whole cell systems) and organocatalysts for the deracemisation of racemic mixtures. (Figure presented.).
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142568
Aranda Álvarez, María del Carmen; Oksdath Mansilla, Gabriela; Bisogno, Fabricio Román; de Gonzalo, Gonzalo; Deracemisation processes employing organocatalysis and enzyme catalysis; Wiley VCH Verlag; Advanced Synthesis & Catalysis (print); 362; 6; 3-2020; 1233-1257
1615-4150
1615-4169
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142568
identifier_str_mv Aranda Álvarez, María del Carmen; Oksdath Mansilla, Gabriela; Bisogno, Fabricio Román; de Gonzalo, Gonzalo; Deracemisation processes employing organocatalysis and enzyme catalysis; Wiley VCH Verlag; Advanced Synthesis & Catalysis (print); 362; 6; 3-2020; 1233-1257
1615-4150
1615-4169
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/adsc.201901112
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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