Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers

Autores
De Queiroz, Alvaro A.A.; França, Écio J.; Abraham, Gustavo Abel; Roman, Julio San
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Solid dispersions of the nonsteriodal antiin-flammatory drug (NSAID) 2′,4′-difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic acid (DIF) with the water-soluble random copolymer poly(N-vinyl-2-pyrrolidone-co-N, N′-dimethylacrylamide) (VP-co-DMAm) were prepared by the solvent method (coevaporates) and melting DIP/VP-co-DMAm (cofused) physical mixtures. Differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to elucidate the possible interaction between the NSAID drug and VP-co-DMAm in cofused and coevaporated polymer-drug solid dispersions. The XRD and FTIR studies suggest the presence of physical interactions with formation of a charge transfer complex between DIF and the VP-co-DMAm copolymers as a consequence of the coevaporation or cofusion processes. In solution, dynamic and equilibrium solubility studies were determined to elucidate the mechanism of interaction between DIP and VP-co-DMAm copolymers. Thermodynamics data about the DIP: VP-co-DMAm dissolution process indicate that the coevaporated systems are more stable that the cofused systems. The dissolution of the cofused and coevaporated systems was diffusion controlled and the dissolution kinetics followed the Noyes-Whitney and the Levich equations. Molecular simulations using semiempirical quantum chemical calculations reinforce the experimental results, suggesting that the improvement in the DIF solubility could be attributed to the charge transfer complex formation between the drug and VP-co-DMAm copolymers.
Fil: De Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; Brasil
Fil: França, Écio J.. Universidade Federal de Itajubá; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Roman, Julio San. Instituto en Ciencia y Tecnología de Polímeros; España
Materia
CHARGE TRANSFER
DIFFUSION
DISPERSIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96666
Acceder
id CONICETDig_5f9de1d35b5b59ba6ebc67c2cb9a4e9a
oai_identifier_str oai:ri.conicet.gov.ar:11336/96666
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymersDe Queiroz, Alvaro A.A.França, Écio J.Abraham, Gustavo AbelRoman, Julio SanCHARGE TRANSFERDIFFUSIONDISPERSIONShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Solid dispersions of the nonsteriodal antiin-flammatory drug (NSAID) 2′,4′-difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic acid (DIF) with the water-soluble random copolymer poly(N-vinyl-2-pyrrolidone-co-N, N′-dimethylacrylamide) (VP-co-DMAm) were prepared by the solvent method (coevaporates) and melting DIP/VP-co-DMAm (cofused) physical mixtures. Differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to elucidate the possible interaction between the NSAID drug and VP-co-DMAm in cofused and coevaporated polymer-drug solid dispersions. The XRD and FTIR studies suggest the presence of physical interactions with formation of a charge transfer complex between DIF and the VP-co-DMAm copolymers as a consequence of the coevaporation or cofusion processes. In solution, dynamic and equilibrium solubility studies were determined to elucidate the mechanism of interaction between DIP and VP-co-DMAm copolymers. Thermodynamics data about the DIP: VP-co-DMAm dissolution process indicate that the coevaporated systems are more stable that the cofused systems. The dissolution of the cofused and coevaporated systems was diffusion controlled and the dissolution kinetics followed the Noyes-Whitney and the Levich equations. Molecular simulations using semiempirical quantum chemical calculations reinforce the experimental results, suggesting that the improvement in the DIF solubility could be attributed to the charge transfer complex formation between the drug and VP-co-DMAm copolymers.Fil: De Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; BrasilFil: França, Écio J.. Universidade Federal de Itajubá; BrasilFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Roman, Julio San. Instituto en Ciencia y Tecnología de Polímeros; EspañaJohn Wiley & Sons Inc2004-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96666De Queiroz, Alvaro A.A.; França, Écio J.; Abraham, Gustavo Abel; Roman, Julio San; Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers; John Wiley & Sons Inc; Journal of Applied Polymer Science; 93; 3; 8-2004; 1337-13470021-8995CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/app.20552info:eu-repo/semantics/altIdentifier/doi/10.1002/app.20552info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:24:34Zoai:ri.conicet.gov.ar:11336/96666instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:24:35.089CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
title Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
spellingShingle Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
De Queiroz, Alvaro A.A.
CHARGE TRANSFER
DIFFUSION
DISPERSIONS
title_short Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
title_full Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
title_fullStr Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
title_full_unstemmed Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
title_sort Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
dc.creator.none.fl_str_mv De Queiroz, Alvaro A.A.
França, Écio J.
Abraham, Gustavo Abel
Roman, Julio San
author De Queiroz, Alvaro A.A.
author_facet De Queiroz, Alvaro A.A.
França, Écio J.
Abraham, Gustavo Abel
Roman, Julio San
author_role author
author2 França, Écio J.
Abraham, Gustavo Abel
Roman, Julio San
author2_role author
author
author
dc.subject.none.fl_str_mv CHARGE TRANSFER
DIFFUSION
DISPERSIONS
topic CHARGE TRANSFER
DIFFUSION
DISPERSIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Solid dispersions of the nonsteriodal antiin-flammatory drug (NSAID) 2′,4′-difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic acid (DIF) with the water-soluble random copolymer poly(N-vinyl-2-pyrrolidone-co-N, N′-dimethylacrylamide) (VP-co-DMAm) were prepared by the solvent method (coevaporates) and melting DIP/VP-co-DMAm (cofused) physical mixtures. Differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to elucidate the possible interaction between the NSAID drug and VP-co-DMAm in cofused and coevaporated polymer-drug solid dispersions. The XRD and FTIR studies suggest the presence of physical interactions with formation of a charge transfer complex between DIF and the VP-co-DMAm copolymers as a consequence of the coevaporation or cofusion processes. In solution, dynamic and equilibrium solubility studies were determined to elucidate the mechanism of interaction between DIP and VP-co-DMAm copolymers. Thermodynamics data about the DIP: VP-co-DMAm dissolution process indicate that the coevaporated systems are more stable that the cofused systems. The dissolution of the cofused and coevaporated systems was diffusion controlled and the dissolution kinetics followed the Noyes-Whitney and the Levich equations. Molecular simulations using semiempirical quantum chemical calculations reinforce the experimental results, suggesting that the improvement in the DIF solubility could be attributed to the charge transfer complex formation between the drug and VP-co-DMAm copolymers.
Fil: De Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; Brasil
Fil: França, Écio J.. Universidade Federal de Itajubá; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Roman, Julio San. Instituto en Ciencia y Tecnología de Polímeros; España
description Solid dispersions of the nonsteriodal antiin-flammatory drug (NSAID) 2′,4′-difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic acid (DIF) with the water-soluble random copolymer poly(N-vinyl-2-pyrrolidone-co-N, N′-dimethylacrylamide) (VP-co-DMAm) were prepared by the solvent method (coevaporates) and melting DIP/VP-co-DMAm (cofused) physical mixtures. Differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to elucidate the possible interaction between the NSAID drug and VP-co-DMAm in cofused and coevaporated polymer-drug solid dispersions. The XRD and FTIR studies suggest the presence of physical interactions with formation of a charge transfer complex between DIF and the VP-co-DMAm copolymers as a consequence of the coevaporation or cofusion processes. In solution, dynamic and equilibrium solubility studies were determined to elucidate the mechanism of interaction between DIP and VP-co-DMAm copolymers. Thermodynamics data about the DIP: VP-co-DMAm dissolution process indicate that the coevaporated systems are more stable that the cofused systems. The dissolution of the cofused and coevaporated systems was diffusion controlled and the dissolution kinetics followed the Noyes-Whitney and the Levich equations. Molecular simulations using semiempirical quantum chemical calculations reinforce the experimental results, suggesting that the improvement in the DIF solubility could be attributed to the charge transfer complex formation between the drug and VP-co-DMAm copolymers.
publishDate 2004
dc.date.none.fl_str_mv 2004-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96666
De Queiroz, Alvaro A.A.; França, Écio J.; Abraham, Gustavo Abel; Roman, Julio San; Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers; John Wiley & Sons Inc; Journal of Applied Polymer Science; 93; 3; 8-2004; 1337-1347
0021-8995
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96666
identifier_str_mv De Queiroz, Alvaro A.A.; França, Écio J.; Abraham, Gustavo Abel; Roman, Julio San; Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers; John Wiley & Sons Inc; Journal of Applied Polymer Science; 93; 3; 8-2004; 1337-1347
0021-8995
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/app.20552
info:eu-repo/semantics/altIdentifier/doi/10.1002/app.20552
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981364909998080
score 12.493442

Publicaciones similares