Should licking behavior be considered in the bioavailability evaluation of transdermal products?
- Autores
- Toutain, P. L.; Modric, S.; Bousquet Mélou, A.; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Antiparasitic drugs, and especially macrocyclic lactones (MLs), are often formulated as pour-on products because of their ease of administration, convenience, and reduction of stress in treated animals. However, because of self- and allo-grooming, much of a drug administered transdermally may be systemically absorbed via the oral route, creating highly variable pharmacokinetic and pharmacodynamic response in treated (and untreated) animals. Testing bioequivalence (BE) of pour-on drugs in cattle under laboratory conditions (with restricted licking) ignores a major factor of drug disposition of these drugs and thus fails to predict therapeutic equivalence in the target population under clinical conditions of use. Therefore, the interanimal and intra-animal variability associated with licking behavior should be considered as a biological fact, rather than a noise that needs to be reduced or eliminated. As a result, it is recommended that the BE testing for pour-on products in cattle be conducted by evaluating both the mean and distribution of bioavailability parameters between the reference and test products when animals are not prevented from allo- and self-licking.
Fil: Toutain, P. L.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; Francia
Fil: Modric, S.. Food and Drug Administration; Estados Unidos
Fil: Bousquet Mélou, A.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; Francia
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Licking Behaviour
Moxidectin
Bovine
Percutaneous Absorption - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/70783
Ver los metadatos del registro completo
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Should licking behavior be considered in the bioavailability evaluation of transdermal products?Toutain, P. L.Modric, S.Bousquet Mélou, A.Sallovitz, Juan ManuelLanusse, Carlos EdmundoLicking BehaviourMoxidectinBovinePercutaneous Absorptionhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Antiparasitic drugs, and especially macrocyclic lactones (MLs), are often formulated as pour-on products because of their ease of administration, convenience, and reduction of stress in treated animals. However, because of self- and allo-grooming, much of a drug administered transdermally may be systemically absorbed via the oral route, creating highly variable pharmacokinetic and pharmacodynamic response in treated (and untreated) animals. Testing bioequivalence (BE) of pour-on drugs in cattle under laboratory conditions (with restricted licking) ignores a major factor of drug disposition of these drugs and thus fails to predict therapeutic equivalence in the target population under clinical conditions of use. Therefore, the interanimal and intra-animal variability associated with licking behavior should be considered as a biological fact, rather than a noise that needs to be reduced or eliminated. As a result, it is recommended that the BE testing for pour-on products in cattle be conducted by evaluating both the mean and distribution of bioavailability parameters between the reference and test products when animals are not prevented from allo- and self-licking.Fil: Toutain, P. L.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; FranciaFil: Modric, S.. Food and Drug Administration; Estados UnidosFil: Bousquet Mélou, A.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; FranciaFil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70783Toutain, P. L.; Modric, S.; Bousquet Mélou, A.; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Should licking behavior be considered in the bioavailability evaluation of transdermal products?; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; SUPPL. 1; 4-2012; 39-430140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2012.01380.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2012.01380.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:06Zoai:ri.conicet.gov.ar:11336/70783instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:06.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
title |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
spellingShingle |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? Toutain, P. L. Licking Behaviour Moxidectin Bovine Percutaneous Absorption |
title_short |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
title_full |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
title_fullStr |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
title_full_unstemmed |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
title_sort |
Should licking behavior be considered in the bioavailability evaluation of transdermal products? |
dc.creator.none.fl_str_mv |
Toutain, P. L. Modric, S. Bousquet Mélou, A. Sallovitz, Juan Manuel Lanusse, Carlos Edmundo |
author |
Toutain, P. L. |
author_facet |
Toutain, P. L. Modric, S. Bousquet Mélou, A. Sallovitz, Juan Manuel Lanusse, Carlos Edmundo |
author_role |
author |
author2 |
Modric, S. Bousquet Mélou, A. Sallovitz, Juan Manuel Lanusse, Carlos Edmundo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Licking Behaviour Moxidectin Bovine Percutaneous Absorption |
topic |
Licking Behaviour Moxidectin Bovine Percutaneous Absorption |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Antiparasitic drugs, and especially macrocyclic lactones (MLs), are often formulated as pour-on products because of their ease of administration, convenience, and reduction of stress in treated animals. However, because of self- and allo-grooming, much of a drug administered transdermally may be systemically absorbed via the oral route, creating highly variable pharmacokinetic and pharmacodynamic response in treated (and untreated) animals. Testing bioequivalence (BE) of pour-on drugs in cattle under laboratory conditions (with restricted licking) ignores a major factor of drug disposition of these drugs and thus fails to predict therapeutic equivalence in the target population under clinical conditions of use. Therefore, the interanimal and intra-animal variability associated with licking behavior should be considered as a biological fact, rather than a noise that needs to be reduced or eliminated. As a result, it is recommended that the BE testing for pour-on products in cattle be conducted by evaluating both the mean and distribution of bioavailability parameters between the reference and test products when animals are not prevented from allo- and self-licking. Fil: Toutain, P. L.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; Francia Fil: Modric, S.. Food and Drug Administration; Estados Unidos Fil: Bousquet Mélou, A.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; Francia Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Antiparasitic drugs, and especially macrocyclic lactones (MLs), are often formulated as pour-on products because of their ease of administration, convenience, and reduction of stress in treated animals. However, because of self- and allo-grooming, much of a drug administered transdermally may be systemically absorbed via the oral route, creating highly variable pharmacokinetic and pharmacodynamic response in treated (and untreated) animals. Testing bioequivalence (BE) of pour-on drugs in cattle under laboratory conditions (with restricted licking) ignores a major factor of drug disposition of these drugs and thus fails to predict therapeutic equivalence in the target population under clinical conditions of use. Therefore, the interanimal and intra-animal variability associated with licking behavior should be considered as a biological fact, rather than a noise that needs to be reduced or eliminated. As a result, it is recommended that the BE testing for pour-on products in cattle be conducted by evaluating both the mean and distribution of bioavailability parameters between the reference and test products when animals are not prevented from allo- and self-licking. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/70783 Toutain, P. L.; Modric, S.; Bousquet Mélou, A.; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Should licking behavior be considered in the bioavailability evaluation of transdermal products?; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; SUPPL. 1; 4-2012; 39-43 0140-7783 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/70783 |
identifier_str_mv |
Toutain, P. L.; Modric, S.; Bousquet Mélou, A.; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Should licking behavior be considered in the bioavailability evaluation of transdermal products?; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; SUPPL. 1; 4-2012; 39-43 0140-7783 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2012.01380.x info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2012.01380.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613418620813312 |
score |
13.070432 |