Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities
- Autores
- Herlax, Vanesa Silvana
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In recent years, research efforts have increased to develop new therapeutics aimed at combating antibiotic resistant bacterial infections. These efforts focus on inhibiting the virulence factors bacteria secrete to proliferate. This review aims to highlight the advances in these antivirulence therapies, with a particular emphasis on those utilizing peptides to inhibit toxin activity. Specifically, we will review the mechanism of action of a group of toxins known as Repeat in ToXins (RTX) and the progress made regarding the use of peptides to inhibit their action. Notably, we will discuss the use of peptides mimicking either cholesterol recognition/interaction amino acid consensus (CRAC) or CARC motifs, which are similar to CRAC motifs but have the opposite orientation, to reduce their interaction with cholesterol in target cells. We will present results corresponding to the inhibition of three characteristic toxins of this group: HlyA from Escherichia coli, LtxA from Aggregatibacter actinomycetemcomitans, and CyaA from Bordetella pertussis. While these advances are very recent, they are promising for the development of new therapies. The advantage of thistype of therapy is that it reduces the selective pressure for the growth of resistant bacteria.
Fil: Herlax, Vanesa Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina - Materia
-
RTX toxins
antivirulence therapies
CRAC/CARC domains
HlyA of E. coli - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/263601
Ver los metadatos del registro completo
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Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activitiesHerlax, Vanesa SilvanaRTX toxinsantivirulence therapiesCRAC/CARC domainsHlyA of E. colihttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In recent years, research efforts have increased to develop new therapeutics aimed at combating antibiotic resistant bacterial infections. These efforts focus on inhibiting the virulence factors bacteria secrete to proliferate. This review aims to highlight the advances in these antivirulence therapies, with a particular emphasis on those utilizing peptides to inhibit toxin activity. Specifically, we will review the mechanism of action of a group of toxins known as Repeat in ToXins (RTX) and the progress made regarding the use of peptides to inhibit their action. Notably, we will discuss the use of peptides mimicking either cholesterol recognition/interaction amino acid consensus (CRAC) or CARC motifs, which are similar to CRAC motifs but have the opposite orientation, to reduce their interaction with cholesterol in target cells. We will present results corresponding to the inhibition of three characteristic toxins of this group: HlyA from Escherichia coli, LtxA from Aggregatibacter actinomycetemcomitans, and CyaA from Bordetella pertussis. While these advances are very recent, they are promising for the development of new therapies. The advantage of thistype of therapy is that it reduces the selective pressure for the growth of resistant bacteria.Fil: Herlax, Vanesa Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaOpen Exploration2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263601Herlax, Vanesa Silvana; Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities; Open Exploration; Exploration of Drug Science; 11-2024; 836-8502836-7677CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.explorationpub.com/Journals/eds/Article/100876info:eu-repo/semantics/altIdentifier/doi/10.37349/eds.2024.00076info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:20Zoai:ri.conicet.gov.ar:11336/263601instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:20.57CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
title |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
spellingShingle |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities Herlax, Vanesa Silvana RTX toxins antivirulence therapies CRAC/CARC domains HlyA of E. coli |
title_short |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
title_full |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
title_fullStr |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
title_full_unstemmed |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
title_sort |
Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities |
dc.creator.none.fl_str_mv |
Herlax, Vanesa Silvana |
author |
Herlax, Vanesa Silvana |
author_facet |
Herlax, Vanesa Silvana |
author_role |
author |
dc.subject.none.fl_str_mv |
RTX toxins antivirulence therapies CRAC/CARC domains HlyA of E. coli |
topic |
RTX toxins antivirulence therapies CRAC/CARC domains HlyA of E. coli |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In recent years, research efforts have increased to develop new therapeutics aimed at combating antibiotic resistant bacterial infections. These efforts focus on inhibiting the virulence factors bacteria secrete to proliferate. This review aims to highlight the advances in these antivirulence therapies, with a particular emphasis on those utilizing peptides to inhibit toxin activity. Specifically, we will review the mechanism of action of a group of toxins known as Repeat in ToXins (RTX) and the progress made regarding the use of peptides to inhibit their action. Notably, we will discuss the use of peptides mimicking either cholesterol recognition/interaction amino acid consensus (CRAC) or CARC motifs, which are similar to CRAC motifs but have the opposite orientation, to reduce their interaction with cholesterol in target cells. We will present results corresponding to the inhibition of three characteristic toxins of this group: HlyA from Escherichia coli, LtxA from Aggregatibacter actinomycetemcomitans, and CyaA from Bordetella pertussis. While these advances are very recent, they are promising for the development of new therapies. The advantage of thistype of therapy is that it reduces the selective pressure for the growth of resistant bacteria. Fil: Herlax, Vanesa Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina |
description |
In recent years, research efforts have increased to develop new therapeutics aimed at combating antibiotic resistant bacterial infections. These efforts focus on inhibiting the virulence factors bacteria secrete to proliferate. This review aims to highlight the advances in these antivirulence therapies, with a particular emphasis on those utilizing peptides to inhibit toxin activity. Specifically, we will review the mechanism of action of a group of toxins known as Repeat in ToXins (RTX) and the progress made regarding the use of peptides to inhibit their action. Notably, we will discuss the use of peptides mimicking either cholesterol recognition/interaction amino acid consensus (CRAC) or CARC motifs, which are similar to CRAC motifs but have the opposite orientation, to reduce their interaction with cholesterol in target cells. We will present results corresponding to the inhibition of three characteristic toxins of this group: HlyA from Escherichia coli, LtxA from Aggregatibacter actinomycetemcomitans, and CyaA from Bordetella pertussis. While these advances are very recent, they are promising for the development of new therapies. The advantage of thistype of therapy is that it reduces the selective pressure for the growth of resistant bacteria. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/263601 Herlax, Vanesa Silvana; Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities; Open Exploration; Exploration of Drug Science; 11-2024; 836-850 2836-7677 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/263601 |
identifier_str_mv |
Herlax, Vanesa Silvana; Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities; Open Exploration; Exploration of Drug Science; 11-2024; 836-850 2836-7677 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.explorationpub.com/Journals/eds/Article/100876 info:eu-repo/semantics/altIdentifier/doi/10.37349/eds.2024.00076 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Open Exploration |
publisher.none.fl_str_mv |
Open Exploration |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |