GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations
- Autores
- Peng, Fuduan; Xiong, Ziyi; Zhu, Gu; Hysi, Pirro G.; Eller, Ryan J.; Wu, Sijie; Adhikari, Kaustubh; Chen, Yan; Li, Yi; Gonzalez-Jose, Rolando; Schüler-Faccini, Lavinia; Bortolini, María Cátira; Acuña Alonzo, Victor; Canizales Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Uitterlinden, André G.; Ikram, M. Arfan; Nijsten, Tamar; Ruiz Linares, Andrés; Wang, Sijia; Walsh, Susan; Spector, Timothy D.; Martin, Nicholas G.; Kayser, Manfred; Liu, Fan
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Natural variation in eyebrow thickness (ET) is one of the most conspicuous facial32 features. Understanding its genetic basis is of broad interest and has implications for33 dermatology and other fields. Two genome-wide association studies (GWASs) for ET34 have been reported thus far. In 2,457 Latin Americans from the CANDELA cohort,35 Adhikari et al. identified 3q22.3 harboring FOXL2 (Adhikari et al., 2016). In 2,96136 Han Chinese from the TZL cohort, Wu et al. discovered 3q26.33 harboring SOX2 and37 5q13.2 harboring FOXD1 and by meta-analysis of CANDELA and TZL 2q12.338 harboring EDAR (Wu et al., 2018). Thus, four ET-associated loci have been39 established thus far, all in non-Europeans. As no European ET GWAS had been40 reported, it remains unknown whether the genetic ET effects described in non-41 Europeans persist in Europeans, or whether there are European-specific genetic loci42 involved in ET, or both.43 Here, we report the first GWAS of ET in Europeans using 9,948 individuals from44 four cohorts of European ancestry, including the Rotterdam Study (RS, n=4,441),45 TwinsUK (n=1,159, females only), the Queensland Institute of Medical Research46 study (QIMR, n=2,257), and a cohort from the United States (US, n=2,121, Table S1,47 Figure S1, Supplementary Materials).
Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China. Md Anderson Cancer Center ; University Of Texas;
Fil: Xiong, Ziyi. University Medical Center Rotterdam; Países Bajos
Fil: Zhu, Gu. Qimr Berghofer Medical Research Institute; Australia
Fil: Hysi, Pirro G.. Colegio Universitario de Londres; Reino Unido
Fil: Eller, Ryan J.. Indiana University; Estados Unidos
Fil: Wu, Sijie. Chinese Academy of Sciences; República de China
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido. The Open University (ou); Reino Unido
Fil: Chen, Yan. Chinese Academy of Sciences; República de China. University Medical Center Rotterdam; Países Bajos. China National Center For Bioinformation; China
Fil: Li, Yi. Chinese Academy of Sciences; República de China. China National Center For Bioinformation; China
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Schüler-Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bortolini, María Cátira. National School of Anthropology and History; México
Fil: Acuña Alonzo, Victor. National School of Anthropology and History; México
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Uitterlinden, André G.. University Medical Center Rotterdam; Países Bajos
Fil: Ikram, M. Arfan. University Medical Center Rotterdam; Países Bajos
Fil: Nijsten, Tamar. University Medical Center Rotterdam; Países Bajos
Fil: Ruiz Linares, Andrés. Fudan University; China. Anthropologie bio-culturelle, droit, éthique et santé; Francia
Fil: Wang, Sijia. Fudan University; China. Chinese Academy of Sciences; República de China
Fil: Walsh, Susan. Indiana University; Estados Unidos
Fil: Spector, Timothy D.. Colegio Universitario de Londres; Reino Unido
Fil: Martin, Nicholas G.. Qimr Berghofer Medical Research Institute; Australia
Fil: Kayser, Manfred. University Medical Center Rotterdam; Países Bajos
Fil: Liu, Fan. Chinese Academy of Sciences; República de China. University Medical Center Rotterdam; Países Bajos. China National Center For Bioinformation; China - Materia
-
EYEBROW THICKNESS
FACIAL TRAITS
GENOMICS
LATIN AMERICANS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/215817
Ver los metadatos del registro completo
| id |
CONICETDig_5f0b9abda61622e8d4b6ee73b46be62b |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/215817 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental PopulationsPeng, FuduanXiong, ZiyiZhu, GuHysi, Pirro G.Eller, Ryan J.Wu, SijieAdhikari, KaustubhChen, YanLi, YiGonzalez-Jose, RolandoSchüler-Faccini, LaviniaBortolini, María CátiraAcuña Alonzo, VictorCanizales Quinteros, SamuelGallo, CarlaPoletti, GiovanniBedoya, GabrielRothhammer, FranciscoUitterlinden, André G.Ikram, M. ArfanNijsten, TamarRuiz Linares, AndrésWang, SijiaWalsh, SusanSpector, Timothy D.Martin, Nicholas G.Kayser, ManfredLiu, FanEYEBROW THICKNESSFACIAL TRAITSGENOMICSLATIN AMERICANShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Natural variation in eyebrow thickness (ET) is one of the most conspicuous facial32 features. Understanding its genetic basis is of broad interest and has implications for33 dermatology and other fields. Two genome-wide association studies (GWASs) for ET34 have been reported thus far. In 2,457 Latin Americans from the CANDELA cohort,35 Adhikari et al. identified 3q22.3 harboring FOXL2 (Adhikari et al., 2016). In 2,96136 Han Chinese from the TZL cohort, Wu et al. discovered 3q26.33 harboring SOX2 and37 5q13.2 harboring FOXD1 and by meta-analysis of CANDELA and TZL 2q12.338 harboring EDAR (Wu et al., 2018). Thus, four ET-associated loci have been39 established thus far, all in non-Europeans. As no European ET GWAS had been40 reported, it remains unknown whether the genetic ET effects described in non-41 Europeans persist in Europeans, or whether there are European-specific genetic loci42 involved in ET, or both.43 Here, we report the first GWAS of ET in Europeans using 9,948 individuals from44 four cohorts of European ancestry, including the Rotterdam Study (RS, n=4,441),45 TwinsUK (n=1,159, females only), the Queensland Institute of Medical Research46 study (QIMR, n=2,257), and a cohort from the United States (US, n=2,121, Table S1,47 Figure S1, Supplementary Materials).Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China. Md Anderson Cancer Center ; University Of Texas;Fil: Xiong, Ziyi. University Medical Center Rotterdam; Países BajosFil: Zhu, Gu. Qimr Berghofer Medical Research Institute; AustraliaFil: Hysi, Pirro G.. Colegio Universitario de Londres; Reino UnidoFil: Eller, Ryan J.. Indiana University; Estados UnidosFil: Wu, Sijie. Chinese Academy of Sciences; República de ChinaFil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido. The Open University (ou); Reino UnidoFil: Chen, Yan. Chinese Academy of Sciences; República de China. University Medical Center Rotterdam; Países Bajos. China National Center For Bioinformation; ChinaFil: Li, Yi. Chinese Academy of Sciences; República de China. China National Center For Bioinformation; ChinaFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Schüler-Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; BrasilFil: Bortolini, María Cátira. National School of Anthropology and History; MéxicoFil: Acuña Alonzo, Victor. National School of Anthropology and History; MéxicoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Bedoya, Gabriel. Universidad de Antioquia; ColombiaFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Uitterlinden, André G.. University Medical Center Rotterdam; Países BajosFil: Ikram, M. Arfan. University Medical Center Rotterdam; Países BajosFil: Nijsten, Tamar. University Medical Center Rotterdam; Países BajosFil: Ruiz Linares, Andrés. Fudan University; China. Anthropologie bio-culturelle, droit, éthique et santé; FranciaFil: Wang, Sijia. Fudan University; China. Chinese Academy of Sciences; República de ChinaFil: Walsh, Susan. Indiana University; Estados UnidosFil: Spector, Timothy D.. Colegio Universitario de Londres; Reino UnidoFil: Martin, Nicholas G.. Qimr Berghofer Medical Research Institute; AustraliaFil: Kayser, Manfred. University Medical Center Rotterdam; Países BajosFil: Liu, Fan. Chinese Academy of Sciences; República de China. University Medical Center Rotterdam; Países Bajos. China National Center For Bioinformation; ChinaNature Publishing Group2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/215817Peng, Fuduan; Xiong, Ziyi; Zhu, Gu; Hysi, Pirro G.; Eller, Ryan J.; et al.; GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations; Nature Publishing Group; Journal Of Investigative Dermatology; 143; 7; 7-2023; 1317-13220022-202XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0022202X23019474info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jid.2022.11.026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:44Zoai:ri.conicet.gov.ar:11336/215817instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:45.217CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| title |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| spellingShingle |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations Peng, Fuduan EYEBROW THICKNESS FACIAL TRAITS GENOMICS LATIN AMERICANS |
| title_short |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| title_full |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| title_fullStr |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| title_full_unstemmed |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| title_sort |
GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations |
| dc.creator.none.fl_str_mv |
Peng, Fuduan Xiong, Ziyi Zhu, Gu Hysi, Pirro G. Eller, Ryan J. Wu, Sijie Adhikari, Kaustubh Chen, Yan Li, Yi Gonzalez-Jose, Rolando Schüler-Faccini, Lavinia Bortolini, María Cátira Acuña Alonzo, Victor Canizales Quinteros, Samuel Gallo, Carla Poletti, Giovanni Bedoya, Gabriel Rothhammer, Francisco Uitterlinden, André G. Ikram, M. Arfan Nijsten, Tamar Ruiz Linares, Andrés Wang, Sijia Walsh, Susan Spector, Timothy D. Martin, Nicholas G. Kayser, Manfred Liu, Fan |
| author |
Peng, Fuduan |
| author_facet |
Peng, Fuduan Xiong, Ziyi Zhu, Gu Hysi, Pirro G. Eller, Ryan J. Wu, Sijie Adhikari, Kaustubh Chen, Yan Li, Yi Gonzalez-Jose, Rolando Schüler-Faccini, Lavinia Bortolini, María Cátira Acuña Alonzo, Victor Canizales Quinteros, Samuel Gallo, Carla Poletti, Giovanni Bedoya, Gabriel Rothhammer, Francisco Uitterlinden, André G. Ikram, M. Arfan Nijsten, Tamar Ruiz Linares, Andrés Wang, Sijia Walsh, Susan Spector, Timothy D. Martin, Nicholas G. Kayser, Manfred Liu, Fan |
| author_role |
author |
| author2 |
Xiong, Ziyi Zhu, Gu Hysi, Pirro G. Eller, Ryan J. Wu, Sijie Adhikari, Kaustubh Chen, Yan Li, Yi Gonzalez-Jose, Rolando Schüler-Faccini, Lavinia Bortolini, María Cátira Acuña Alonzo, Victor Canizales Quinteros, Samuel Gallo, Carla Poletti, Giovanni Bedoya, Gabriel Rothhammer, Francisco Uitterlinden, André G. Ikram, M. Arfan Nijsten, Tamar Ruiz Linares, Andrés Wang, Sijia Walsh, Susan Spector, Timothy D. Martin, Nicholas G. Kayser, Manfred Liu, Fan |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
EYEBROW THICKNESS FACIAL TRAITS GENOMICS LATIN AMERICANS |
| topic |
EYEBROW THICKNESS FACIAL TRAITS GENOMICS LATIN AMERICANS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Natural variation in eyebrow thickness (ET) is one of the most conspicuous facial32 features. Understanding its genetic basis is of broad interest and has implications for33 dermatology and other fields. Two genome-wide association studies (GWASs) for ET34 have been reported thus far. In 2,457 Latin Americans from the CANDELA cohort,35 Adhikari et al. identified 3q22.3 harboring FOXL2 (Adhikari et al., 2016). In 2,96136 Han Chinese from the TZL cohort, Wu et al. discovered 3q26.33 harboring SOX2 and37 5q13.2 harboring FOXD1 and by meta-analysis of CANDELA and TZL 2q12.338 harboring EDAR (Wu et al., 2018). Thus, four ET-associated loci have been39 established thus far, all in non-Europeans. As no European ET GWAS had been40 reported, it remains unknown whether the genetic ET effects described in non-41 Europeans persist in Europeans, or whether there are European-specific genetic loci42 involved in ET, or both.43 Here, we report the first GWAS of ET in Europeans using 9,948 individuals from44 four cohorts of European ancestry, including the Rotterdam Study (RS, n=4,441),45 TwinsUK (n=1,159, females only), the Queensland Institute of Medical Research46 study (QIMR, n=2,257), and a cohort from the United States (US, n=2,121, Table S1,47 Figure S1, Supplementary Materials). Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China. Md Anderson Cancer Center ; University Of Texas; Fil: Xiong, Ziyi. University Medical Center Rotterdam; Países Bajos Fil: Zhu, Gu. Qimr Berghofer Medical Research Institute; Australia Fil: Hysi, Pirro G.. Colegio Universitario de Londres; Reino Unido Fil: Eller, Ryan J.. Indiana University; Estados Unidos Fil: Wu, Sijie. Chinese Academy of Sciences; República de China Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido. The Open University (ou); Reino Unido Fil: Chen, Yan. Chinese Academy of Sciences; República de China. University Medical Center Rotterdam; Países Bajos. China National Center For Bioinformation; China Fil: Li, Yi. Chinese Academy of Sciences; República de China. China National Center For Bioinformation; China Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Schüler-Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil Fil: Bortolini, María Cátira. National School of Anthropology and History; México Fil: Acuña Alonzo, Victor. National School of Anthropology and History; México Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Uitterlinden, André G.. University Medical Center Rotterdam; Países Bajos Fil: Ikram, M. Arfan. University Medical Center Rotterdam; Países Bajos Fil: Nijsten, Tamar. University Medical Center Rotterdam; Países Bajos Fil: Ruiz Linares, Andrés. Fudan University; China. Anthropologie bio-culturelle, droit, éthique et santé; Francia Fil: Wang, Sijia. Fudan University; China. Chinese Academy of Sciences; República de China Fil: Walsh, Susan. Indiana University; Estados Unidos Fil: Spector, Timothy D.. Colegio Universitario de Londres; Reino Unido Fil: Martin, Nicholas G.. Qimr Berghofer Medical Research Institute; Australia Fil: Kayser, Manfred. University Medical Center Rotterdam; Países Bajos Fil: Liu, Fan. Chinese Academy of Sciences; República de China. University Medical Center Rotterdam; Países Bajos. China National Center For Bioinformation; China |
| description |
Natural variation in eyebrow thickness (ET) is one of the most conspicuous facial32 features. Understanding its genetic basis is of broad interest and has implications for33 dermatology and other fields. Two genome-wide association studies (GWASs) for ET34 have been reported thus far. In 2,457 Latin Americans from the CANDELA cohort,35 Adhikari et al. identified 3q22.3 harboring FOXL2 (Adhikari et al., 2016). In 2,96136 Han Chinese from the TZL cohort, Wu et al. discovered 3q26.33 harboring SOX2 and37 5q13.2 harboring FOXD1 and by meta-analysis of CANDELA and TZL 2q12.338 harboring EDAR (Wu et al., 2018). Thus, four ET-associated loci have been39 established thus far, all in non-Europeans. As no European ET GWAS had been40 reported, it remains unknown whether the genetic ET effects described in non-41 Europeans persist in Europeans, or whether there are European-specific genetic loci42 involved in ET, or both.43 Here, we report the first GWAS of ET in Europeans using 9,948 individuals from44 four cohorts of European ancestry, including the Rotterdam Study (RS, n=4,441),45 TwinsUK (n=1,159, females only), the Queensland Institute of Medical Research46 study (QIMR, n=2,257), and a cohort from the United States (US, n=2,121, Table S1,47 Figure S1, Supplementary Materials). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/215817 Peng, Fuduan; Xiong, Ziyi; Zhu, Gu; Hysi, Pirro G.; Eller, Ryan J.; et al.; GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations; Nature Publishing Group; Journal Of Investigative Dermatology; 143; 7; 7-2023; 1317-1322 0022-202X CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/215817 |
| identifier_str_mv |
Peng, Fuduan; Xiong, Ziyi; Zhu, Gu; Hysi, Pirro G.; Eller, Ryan J.; et al.; GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations; Nature Publishing Group; Journal Of Investigative Dermatology; 143; 7; 7-2023; 1317-1322 0022-202X CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0022202X23019474 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jid.2022.11.026 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
| publisher.none.fl_str_mv |
Nature Publishing Group |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1844613563397701632 |
| score |
13.070432 |