Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America

Autores
Venzon Antunes, Marina; Linden, Rafael; Schaiquevich, Paula Susana
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease conditions, drug-drug and drug-herbal interactions, noncompliance, and genetic features affect the relationship between drug concentrations in the body and clinical effects. They contribute to the pharmacokinetic inter-patient variability which ultimately impactsdrug response, resulting in some patients showing lack of therapeutic effects while others experience toxicity. Thus, the identification of the sources of pharmacokinetic variability contributes to the adequacy of the dosing regimen [1]. However, performing TDM in Developing Nations as South American Countries is particularly challenging, mainly due to the lack of structure and economic aspects.
Fil: Venzon Antunes, Marina. Universidade Feevale; Brasil
Fil: Linden, Rafael. Universidade Feevale; Brasil
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Materia
DEVELOPING NATION
PHARMACOGENETIC
SOUTH AMERICA
THERAPEUTIC DRUG MONITORING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163919
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South AmericaVenzon Antunes, MarinaLinden, RafaelSchaiquevich, Paula SusanaDEVELOPING NATIONPHARMACOGENETICSOUTH AMERICATHERAPEUTIC DRUG MONITORINGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease conditions, drug-drug and drug-herbal interactions, noncompliance, and genetic features affect the relationship between drug concentrations in the body and clinical effects. They contribute to the pharmacokinetic inter-patient variability which ultimately impactsdrug response, resulting in some patients showing lack of therapeutic effects while others experience toxicity. Thus, the identification of the sources of pharmacokinetic variability contributes to the adequacy of the dosing regimen [1]. However, performing TDM in Developing Nations as South American Countries is particularly challenging, mainly due to the lack of structure and economic aspects.Fil: Venzon Antunes, Marina. Universidade Feevale; BrasilFil: Linden, Rafael. Universidade Feevale; BrasilFil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaTaylor & Francis2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163919Venzon Antunes, Marina; Linden, Rafael; Schaiquevich, Paula Susana; Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America; Taylor & Francis; Expert Opinion on Drug Metabolism & Toxicology; 17; 3; 1-2021; 251-2541742-5255CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/17425255.2021.1859478info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17425255.2021.1859478info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:23:13Zoai:ri.conicet.gov.ar:11336/163919instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:23:14.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
title Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
spellingShingle Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
Venzon Antunes, Marina
DEVELOPING NATION
PHARMACOGENETIC
SOUTH AMERICA
THERAPEUTIC DRUG MONITORING
title_short Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
title_full Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
title_fullStr Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
title_full_unstemmed Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
title_sort Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
dc.creator.none.fl_str_mv Venzon Antunes, Marina
Linden, Rafael
Schaiquevich, Paula Susana
author Venzon Antunes, Marina
author_facet Venzon Antunes, Marina
Linden, Rafael
Schaiquevich, Paula Susana
author_role author
author2 Linden, Rafael
Schaiquevich, Paula Susana
author2_role author
author
dc.subject.none.fl_str_mv DEVELOPING NATION
PHARMACOGENETIC
SOUTH AMERICA
THERAPEUTIC DRUG MONITORING
topic DEVELOPING NATION
PHARMACOGENETIC
SOUTH AMERICA
THERAPEUTIC DRUG MONITORING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease conditions, drug-drug and drug-herbal interactions, noncompliance, and genetic features affect the relationship between drug concentrations in the body and clinical effects. They contribute to the pharmacokinetic inter-patient variability which ultimately impactsdrug response, resulting in some patients showing lack of therapeutic effects while others experience toxicity. Thus, the identification of the sources of pharmacokinetic variability contributes to the adequacy of the dosing regimen [1]. However, performing TDM in Developing Nations as South American Countries is particularly challenging, mainly due to the lack of structure and economic aspects.
Fil: Venzon Antunes, Marina. Universidade Feevale; Brasil
Fil: Linden, Rafael. Universidade Feevale; Brasil
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
description Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease conditions, drug-drug and drug-herbal interactions, noncompliance, and genetic features affect the relationship between drug concentrations in the body and clinical effects. They contribute to the pharmacokinetic inter-patient variability which ultimately impactsdrug response, resulting in some patients showing lack of therapeutic effects while others experience toxicity. Thus, the identification of the sources of pharmacokinetic variability contributes to the adequacy of the dosing regimen [1]. However, performing TDM in Developing Nations as South American Countries is particularly challenging, mainly due to the lack of structure and economic aspects.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163919
Venzon Antunes, Marina; Linden, Rafael; Schaiquevich, Paula Susana; Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America; Taylor & Francis; Expert Opinion on Drug Metabolism & Toxicology; 17; 3; 1-2021; 251-254
1742-5255
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163919
identifier_str_mv Venzon Antunes, Marina; Linden, Rafael; Schaiquevich, Paula Susana; Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America; Taylor & Francis; Expert Opinion on Drug Metabolism & Toxicology; 17; 3; 1-2021; 251-254
1742-5255
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/17425255.2021.1859478
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17425255.2021.1859478
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781758748491776
score 12.982451

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