Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area

Autores
Rivarola, Hector Walter; Bustamante, Juan Manuel; Lo Presti, Maria Silvina; Fernandez, Alicia Ruth; Enders, Julio Enrique; Gea, Susana; Fretes, Ricardo Emilio; Paglini, Patricia Adriana
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The susceptibility of Trypanosoma cruzi strains to nifurtimox and benznidazole has been investigated and resistant strains have been described. Some tricyclic drugs are lethal for trypomastigote and epimastigote forms of T. cruzi (Tulahuen strain) and prevent the disease in mice. We investigated whether clomipramine, a tricyclic antidepressant drug with anti-trypanothione reductase and anti-calmodulin eVects, could be eVective in treating Albino Swiss mice infected with trypomastigotes of a new T. cruzi isolate from a chronic patient from an endemic area of Argentina in two diVerent treatment schedules. Both treatment schedules were eVective in reducing electrocardiographic changes and preventing myocardial structural damage. The cardiac -receptors low aYnity was compensated for by an increment in their density. This probably maintained cardiac function since 70% of the mice survived for more than 2 years even though anti-cruzipain titers remained high. These results demonstrate that clomipramine, clinically used as a neuroleptic, could be a promising trypanocidal agent for the treatment of Chagas’ disease.
Fil: Rivarola, Hector Walter. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Bustamante, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Fernandez, Alicia Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Cátedra de Inmunología; Argentina
Fil: Enders, Julio Enrique. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Gea, Susana. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Fretes, Ricardo Emilio. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Histología, Embriología y Genética II; Argentina
Fil: Paglini, Patricia Adriana. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Materia
T. cruzi strains
Chagas’ disease treatment
Clomipramine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241840
Acceder
id CONICETDig_5eb4ec5b85441b20e9fc0fc67b782787
oai_identifier_str oai:ri.conicet.gov.ar:11336/241840
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic areaRivarola, Hector WalterBustamante, Juan ManuelLo Presti, Maria SilvinaFernandez, Alicia RuthEnders, Julio EnriqueGea, SusanaFretes, Ricardo EmilioPaglini, Patricia AdrianaT. cruzi strainsChagas’ disease treatmentClomipraminehttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The susceptibility of Trypanosoma cruzi strains to nifurtimox and benznidazole has been investigated and resistant strains have been described. Some tricyclic drugs are lethal for trypomastigote and epimastigote forms of T. cruzi (Tulahuen strain) and prevent the disease in mice. We investigated whether clomipramine, a tricyclic antidepressant drug with anti-trypanothione reductase and anti-calmodulin eVects, could be eVective in treating Albino Swiss mice infected with trypomastigotes of a new T. cruzi isolate from a chronic patient from an endemic area of Argentina in two diVerent treatment schedules. Both treatment schedules were eVective in reducing electrocardiographic changes and preventing myocardial structural damage. The cardiac -receptors low aYnity was compensated for by an increment in their density. This probably maintained cardiac function since 70% of the mice survived for more than 2 years even though anti-cruzipain titers remained high. These results demonstrate that clomipramine, clinically used as a neuroleptic, could be a promising trypanocidal agent for the treatment of Chagas’ disease.Fil: Rivarola, Hector Walter. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; ArgentinaFil: Bustamante, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; ArgentinaFil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; ArgentinaFil: Fernandez, Alicia Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Cátedra de Inmunología; ArgentinaFil: Enders, Julio Enrique. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; ArgentinaFil: Gea, Susana. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Fretes, Ricardo Emilio. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Histología, Embriología y Genética II; ArgentinaFil: Paglini, Patricia Adriana. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; ArgentinaAcademic Press Inc Elsevier Science2005-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241840Rivarola, Hector Walter; Bustamante, Juan Manuel; Lo Presti, Maria Silvina; Fernandez, Alicia Ruth; Enders, Julio Enrique; et al.; Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area; Academic Press Inc Elsevier Science; Experimental Parasitology; 111; 2; 10-2005; 80-860014-4894CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014489405001475info:eu-repo/semantics/altIdentifier/doi/10.1016/j.exppara.2005.05.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:49Zoai:ri.conicet.gov.ar:11336/241840instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:49.35CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
title Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
spellingShingle Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
Rivarola, Hector Walter
T. cruzi strains
Chagas’ disease treatment
Clomipramine
title_short Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
title_full Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
title_fullStr Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
title_full_unstemmed Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
title_sort Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area
dc.creator.none.fl_str_mv Rivarola, Hector Walter
Bustamante, Juan Manuel
Lo Presti, Maria Silvina
Fernandez, Alicia Ruth
Enders, Julio Enrique
Gea, Susana
Fretes, Ricardo Emilio
Paglini, Patricia Adriana
author Rivarola, Hector Walter
author_facet Rivarola, Hector Walter
Bustamante, Juan Manuel
Lo Presti, Maria Silvina
Fernandez, Alicia Ruth
Enders, Julio Enrique
Gea, Susana
Fretes, Ricardo Emilio
Paglini, Patricia Adriana
author_role author
author2 Bustamante, Juan Manuel
Lo Presti, Maria Silvina
Fernandez, Alicia Ruth
Enders, Julio Enrique
Gea, Susana
Fretes, Ricardo Emilio
Paglini, Patricia Adriana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv T. cruzi strains
Chagas’ disease treatment
Clomipramine
topic T. cruzi strains
Chagas’ disease treatment
Clomipramine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The susceptibility of Trypanosoma cruzi strains to nifurtimox and benznidazole has been investigated and resistant strains have been described. Some tricyclic drugs are lethal for trypomastigote and epimastigote forms of T. cruzi (Tulahuen strain) and prevent the disease in mice. We investigated whether clomipramine, a tricyclic antidepressant drug with anti-trypanothione reductase and anti-calmodulin eVects, could be eVective in treating Albino Swiss mice infected with trypomastigotes of a new T. cruzi isolate from a chronic patient from an endemic area of Argentina in two diVerent treatment schedules. Both treatment schedules were eVective in reducing electrocardiographic changes and preventing myocardial structural damage. The cardiac -receptors low aYnity was compensated for by an increment in their density. This probably maintained cardiac function since 70% of the mice survived for more than 2 years even though anti-cruzipain titers remained high. These results demonstrate that clomipramine, clinically used as a neuroleptic, could be a promising trypanocidal agent for the treatment of Chagas’ disease.
Fil: Rivarola, Hector Walter. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Bustamante, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Fernandez, Alicia Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Cátedra de Inmunología; Argentina
Fil: Enders, Julio Enrique. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
Fil: Gea, Susana. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Fretes, Ricardo Emilio. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Histología, Embriología y Genética II; Argentina
Fil: Paglini, Patricia Adriana. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Física Biomedica; Argentina
description The susceptibility of Trypanosoma cruzi strains to nifurtimox and benznidazole has been investigated and resistant strains have been described. Some tricyclic drugs are lethal for trypomastigote and epimastigote forms of T. cruzi (Tulahuen strain) and prevent the disease in mice. We investigated whether clomipramine, a tricyclic antidepressant drug with anti-trypanothione reductase and anti-calmodulin eVects, could be eVective in treating Albino Swiss mice infected with trypomastigotes of a new T. cruzi isolate from a chronic patient from an endemic area of Argentina in two diVerent treatment schedules. Both treatment schedules were eVective in reducing electrocardiographic changes and preventing myocardial structural damage. The cardiac -receptors low aYnity was compensated for by an increment in their density. This probably maintained cardiac function since 70% of the mice survived for more than 2 years even though anti-cruzipain titers remained high. These results demonstrate that clomipramine, clinically used as a neuroleptic, could be a promising trypanocidal agent for the treatment of Chagas’ disease.
publishDate 2005
dc.date.none.fl_str_mv 2005-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241840
Rivarola, Hector Walter; Bustamante, Juan Manuel; Lo Presti, Maria Silvina; Fernandez, Alicia Ruth; Enders, Julio Enrique; et al.; Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area; Academic Press Inc Elsevier Science; Experimental Parasitology; 111; 2; 10-2005; 80-86
0014-4894
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241840
identifier_str_mv Rivarola, Hector Walter; Bustamante, Juan Manuel; Lo Presti, Maria Silvina; Fernandez, Alicia Ruth; Enders, Julio Enrique; et al.; Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area; Academic Press Inc Elsevier Science; Experimental Parasitology; 111; 2; 10-2005; 80-86
0014-4894
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014489405001475
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.exppara.2005.05.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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