Effect of neonatal treatment with clomipramine on consummatory successive negative contrast

Autores
Ruetti, Eliana Martha; Burgueño, Adriana Laura; Justel, Nadia; Pirola, Carlos José; Mustaca, Alba Elisabeth
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neonatal administration of clomipramine (CLI) produces physiological, neuroendocrinal and behavioral abnormalities in rats when they reach adulthood, which are similar to those observed in animal models of depression. In consummatory successive negative contrast (cSNC), rats that have had experience drinking 32% sucrose solution drink significantly less 4% sucrose solution than rats that have drunk only 4% solution. It triggers an aversive-emotional reaction similar to fear or anxiety. We studied whether neonatal treatment with CLI alters the cSNC’s response in adult rats. The findings of the present work suggest that the neonatal treatment with an antidepressive could generate an increase tolerance to frustration in adult animals. CLI rats showed a faster recovery from the cSNC than control animals, which may be explained by an alteration of the HypothalamicPituitary-Adrenal axis (HPA), a serotonergic system deficit, a low expectative formation during pre-shift phase, or a combination of all these factors.
Fil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Mustaca, Alba Elisabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Neonatal treatment
Clomipramine
Frustration
Rats
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20661
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/20661
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network_name_str CONICET Digital (CONICET)
spelling Effect of neonatal treatment with clomipramine on consummatory successive negative contrastRuetti, Eliana MarthaBurgueño, Adriana LauraJustel, NadiaPirola, Carlos JoséMustaca, Alba ElisabethNeonatal treatmentClomipramineFrustrationRatshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Neonatal administration of clomipramine (CLI) produces physiological, neuroendocrinal and behavioral abnormalities in rats when they reach adulthood, which are similar to those observed in animal models of depression. In consummatory successive negative contrast (cSNC), rats that have had experience drinking 32% sucrose solution drink significantly less 4% sucrose solution than rats that have drunk only 4% solution. It triggers an aversive-emotional reaction similar to fear or anxiety. We studied whether neonatal treatment with CLI alters the cSNC’s response in adult rats. The findings of the present work suggest that the neonatal treatment with an antidepressive could generate an increase tolerance to frustration in adult animals. CLI rats showed a faster recovery from the cSNC than control animals, which may be explained by an alteration of the HypothalamicPituitary-Adrenal axis (HPA), a serotonergic system deficit, a low expectative formation during pre-shift phase, or a combination of all these factors.Fil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Mustaca, Alba Elisabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaUniversidad de Valencia. Departamento de Metodología de las Ciencias del Comportamiento2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20661Ruetti, Eliana Martha; Burgueño, Adriana Laura; Justel, Nadia; Pirola, Carlos José; Mustaca, Alba Elisabeth; Effect of neonatal treatment with clomipramine on consummatory successive negative contrast; Universidad de Valencia. Departamento de Metodología de las Ciencias del Comportamiento; Psicológica; 34; 1; 1-2013; 25-360211-21591576-8597CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.uv.es/psicologica/paraARCHIVES/2013.htmlinfo:eu-repo/semantics/altIdentifier/url/http://www.redalyc.org/articulo.oa?id=16929533002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:02Zoai:ri.conicet.gov.ar:11336/20661instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:02.517CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
title Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
spellingShingle Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
Ruetti, Eliana Martha
Neonatal treatment
Clomipramine
Frustration
Rats
title_short Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
title_full Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
title_fullStr Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
title_full_unstemmed Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
title_sort Effect of neonatal treatment with clomipramine on consummatory successive negative contrast
dc.creator.none.fl_str_mv Ruetti, Eliana Martha
Burgueño, Adriana Laura
Justel, Nadia
Pirola, Carlos José
Mustaca, Alba Elisabeth
author Ruetti, Eliana Martha
author_facet Ruetti, Eliana Martha
Burgueño, Adriana Laura
Justel, Nadia
Pirola, Carlos José
Mustaca, Alba Elisabeth
author_role author
author2 Burgueño, Adriana Laura
Justel, Nadia
Pirola, Carlos José
Mustaca, Alba Elisabeth
author2_role author
author
author
author
dc.subject.none.fl_str_mv Neonatal treatment
Clomipramine
Frustration
Rats
topic Neonatal treatment
Clomipramine
Frustration
Rats
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Neonatal administration of clomipramine (CLI) produces physiological, neuroendocrinal and behavioral abnormalities in rats when they reach adulthood, which are similar to those observed in animal models of depression. In consummatory successive negative contrast (cSNC), rats that have had experience drinking 32% sucrose solution drink significantly less 4% sucrose solution than rats that have drunk only 4% solution. It triggers an aversive-emotional reaction similar to fear or anxiety. We studied whether neonatal treatment with CLI alters the cSNC’s response in adult rats. The findings of the present work suggest that the neonatal treatment with an antidepressive could generate an increase tolerance to frustration in adult animals. CLI rats showed a faster recovery from the cSNC than control animals, which may be explained by an alteration of the HypothalamicPituitary-Adrenal axis (HPA), a serotonergic system deficit, a low expectative formation during pre-shift phase, or a combination of all these factors.
Fil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Mustaca, Alba Elisabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Neonatal administration of clomipramine (CLI) produces physiological, neuroendocrinal and behavioral abnormalities in rats when they reach adulthood, which are similar to those observed in animal models of depression. In consummatory successive negative contrast (cSNC), rats that have had experience drinking 32% sucrose solution drink significantly less 4% sucrose solution than rats that have drunk only 4% solution. It triggers an aversive-emotional reaction similar to fear or anxiety. We studied whether neonatal treatment with CLI alters the cSNC’s response in adult rats. The findings of the present work suggest that the neonatal treatment with an antidepressive could generate an increase tolerance to frustration in adult animals. CLI rats showed a faster recovery from the cSNC than control animals, which may be explained by an alteration of the HypothalamicPituitary-Adrenal axis (HPA), a serotonergic system deficit, a low expectative formation during pre-shift phase, or a combination of all these factors.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20661
Ruetti, Eliana Martha; Burgueño, Adriana Laura; Justel, Nadia; Pirola, Carlos José; Mustaca, Alba Elisabeth; Effect of neonatal treatment with clomipramine on consummatory successive negative contrast; Universidad de Valencia. Departamento de Metodología de las Ciencias del Comportamiento; Psicológica; 34; 1; 1-2013; 25-36
0211-2159
1576-8597
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20661
identifier_str_mv Ruetti, Eliana Martha; Burgueño, Adriana Laura; Justel, Nadia; Pirola, Carlos José; Mustaca, Alba Elisabeth; Effect of neonatal treatment with clomipramine on consummatory successive negative contrast; Universidad de Valencia. Departamento de Metodología de las Ciencias del Comportamiento; Psicológica; 34; 1; 1-2013; 25-36
0211-2159
1576-8597
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.uv.es/psicologica/paraARCHIVES/2013.html
info:eu-repo/semantics/altIdentifier/url/http://www.redalyc.org/articulo.oa?id=16929533002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidad de Valencia. Departamento de Metodología de las Ciencias del Comportamiento
publisher.none.fl_str_mv Universidad de Valencia. Departamento de Metodología de las Ciencias del Comportamiento
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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