Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina

Autores
Urtasun, María; Daray, Federico Manuel; Teti, Germán Leandro; Coppolillo, Fernando Enrique; Herlax, Gabriela; Saba, Guillermo; Rubinstein, Adolfo Luis; Araya, Ricardo; Irazola, Vilma
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off points for different degrees of severity of depression in Argentina. Methods: We conducted a cross-sectional study on an intentional sample of adult ambulatory care patients with different degrees of severity of depression. All patients who completed the PHQ-9 were further interviewed by a trained clinician with the Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory-II (BDI-II). Reliability and validity tests, including receiver operating curve analysis, were performed. Results: One hundred sixty-nine patients were recruited with a mean age of 47.4 years (SD = 14.8), of whom 102 were females (60.4%). The local PHQ-9 had high internal consistency (Cronbach's alpha = 0.87) and satisfactory convergent validity with the BDI-II scale [Pearson's correlation = 0.88 (p < 0.01)]. For the diagnosis of Major Depressive Episode (MDE) according to the MINI, a PHQ-9 ≥ 8 was the optimal cut-off point found (sensitivity 88.2%, specificity 86.6%, PPV 90.91%). The local version of PHQ-9 showed good ability to discriminate among depression severity categories according to the BDI-II scale. The best cut off points were 6-8 for mild cases, 9-14 for moderate and 15 or more for severe depressive symptoms respectively. Conclusions: The Argentine version of the PHQ-9 questionnaire has shown acceptable validity and reliability for both screening and severity assessment of depressive symptoms.
Fil: Urtasun, María. Instituto de Efectividad Clínica y Sanitaria; Argentina. Universidad de Alcalá; España
Fil: Daray, Federico Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Teti, Germán Leandro. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Coppolillo, Fernando Enrique. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Herlax, Gabriela. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Saba, Guillermo. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Araya, Ricardo. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Irazola, Vilma. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ARGENTINA
DEPRESSION
MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW
PATIENT HEALTH QUESTIONNAIRE-9
PSYCHOMETRICS
SCREENING INSTRUMENTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147518
Acceder
id CONICETDig_5e638314de7c719786254e3e3c052cd5
oai_identifier_str oai:ri.conicet.gov.ar:11336/147518
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Validation and calibration of the patient health questionnaire (PHQ-9) in ArgentinaUrtasun, MaríaDaray, Federico ManuelTeti, Germán LeandroCoppolillo, Fernando EnriqueHerlax, GabrielaSaba, GuillermoRubinstein, Adolfo LuisAraya, RicardoIrazola, VilmaARGENTINADEPRESSIONMINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEWPATIENT HEALTH QUESTIONNAIRE-9PSYCHOMETRICSSCREENING INSTRUMENTShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off points for different degrees of severity of depression in Argentina. Methods: We conducted a cross-sectional study on an intentional sample of adult ambulatory care patients with different degrees of severity of depression. All patients who completed the PHQ-9 were further interviewed by a trained clinician with the Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory-II (BDI-II). Reliability and validity tests, including receiver operating curve analysis, were performed. Results: One hundred sixty-nine patients were recruited with a mean age of 47.4 years (SD = 14.8), of whom 102 were females (60.4%). The local PHQ-9 had high internal consistency (Cronbach's alpha = 0.87) and satisfactory convergent validity with the BDI-II scale [Pearson's correlation = 0.88 (p < 0.01)]. For the diagnosis of Major Depressive Episode (MDE) according to the MINI, a PHQ-9 ≥ 8 was the optimal cut-off point found (sensitivity 88.2%, specificity 86.6%, PPV 90.91%). The local version of PHQ-9 showed good ability to discriminate among depression severity categories according to the BDI-II scale. The best cut off points were 6-8 for mild cases, 9-14 for moderate and 15 or more for severe depressive symptoms respectively. Conclusions: The Argentine version of the PHQ-9 questionnaire has shown acceptable validity and reliability for both screening and severity assessment of depressive symptoms.Fil: Urtasun, María. Instituto de Efectividad Clínica y Sanitaria; Argentina. Universidad de Alcalá; EspañaFil: Daray, Federico Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Teti, Germán Leandro. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; ArgentinaFil: Coppolillo, Fernando Enrique. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Herlax, Gabriela. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Saba, Guillermo. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Araya, Ricardo. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Irazola, Vilma. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBioMed Central2019-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147518Urtasun, María; Daray, Federico Manuel; Teti, Germán Leandro; Coppolillo, Fernando Enrique; Herlax, Gabriela; et al.; Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina; BioMed Central; Bmc Psychiatry; 19; 1; 9-2019; 1-101471-244XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-019-2262-9info:eu-repo/semantics/altIdentifier/doi/10.1186/s12888-019-2262-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:08:20Zoai:ri.conicet.gov.ar:11336/147518instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:08:20.421CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
title Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
spellingShingle Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
Urtasun, María
ARGENTINA
DEPRESSION
MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW
PATIENT HEALTH QUESTIONNAIRE-9
PSYCHOMETRICS
SCREENING INSTRUMENTS
title_short Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
title_full Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
title_fullStr Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
title_full_unstemmed Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
title_sort Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
dc.creator.none.fl_str_mv Urtasun, María
Daray, Federico Manuel
Teti, Germán Leandro
Coppolillo, Fernando Enrique
Herlax, Gabriela
Saba, Guillermo
Rubinstein, Adolfo Luis
Araya, Ricardo
Irazola, Vilma
author Urtasun, María
author_facet Urtasun, María
Daray, Federico Manuel
Teti, Germán Leandro
Coppolillo, Fernando Enrique
Herlax, Gabriela
Saba, Guillermo
Rubinstein, Adolfo Luis
Araya, Ricardo
Irazola, Vilma
author_role author
author2 Daray, Federico Manuel
Teti, Germán Leandro
Coppolillo, Fernando Enrique
Herlax, Gabriela
Saba, Guillermo
Rubinstein, Adolfo Luis
Araya, Ricardo
Irazola, Vilma
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINA
DEPRESSION
MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW
PATIENT HEALTH QUESTIONNAIRE-9
PSYCHOMETRICS
SCREENING INSTRUMENTS
topic ARGENTINA
DEPRESSION
MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW
PATIENT HEALTH QUESTIONNAIRE-9
PSYCHOMETRICS
SCREENING INSTRUMENTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off points for different degrees of severity of depression in Argentina. Methods: We conducted a cross-sectional study on an intentional sample of adult ambulatory care patients with different degrees of severity of depression. All patients who completed the PHQ-9 were further interviewed by a trained clinician with the Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory-II (BDI-II). Reliability and validity tests, including receiver operating curve analysis, were performed. Results: One hundred sixty-nine patients were recruited with a mean age of 47.4 years (SD = 14.8), of whom 102 were females (60.4%). The local PHQ-9 had high internal consistency (Cronbach's alpha = 0.87) and satisfactory convergent validity with the BDI-II scale [Pearson's correlation = 0.88 (p < 0.01)]. For the diagnosis of Major Depressive Episode (MDE) according to the MINI, a PHQ-9 ≥ 8 was the optimal cut-off point found (sensitivity 88.2%, specificity 86.6%, PPV 90.91%). The local version of PHQ-9 showed good ability to discriminate among depression severity categories according to the BDI-II scale. The best cut off points were 6-8 for mild cases, 9-14 for moderate and 15 or more for severe depressive symptoms respectively. Conclusions: The Argentine version of the PHQ-9 questionnaire has shown acceptable validity and reliability for both screening and severity assessment of depressive symptoms.
Fil: Urtasun, María. Instituto de Efectividad Clínica y Sanitaria; Argentina. Universidad de Alcalá; España
Fil: Daray, Federico Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Teti, Germán Leandro. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Coppolillo, Fernando Enrique. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Herlax, Gabriela. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Saba, Guillermo. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Araya, Ricardo. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Irazola, Vilma. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off points for different degrees of severity of depression in Argentina. Methods: We conducted a cross-sectional study on an intentional sample of adult ambulatory care patients with different degrees of severity of depression. All patients who completed the PHQ-9 were further interviewed by a trained clinician with the Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory-II (BDI-II). Reliability and validity tests, including receiver operating curve analysis, were performed. Results: One hundred sixty-nine patients were recruited with a mean age of 47.4 years (SD = 14.8), of whom 102 were females (60.4%). The local PHQ-9 had high internal consistency (Cronbach's alpha = 0.87) and satisfactory convergent validity with the BDI-II scale [Pearson's correlation = 0.88 (p < 0.01)]. For the diagnosis of Major Depressive Episode (MDE) according to the MINI, a PHQ-9 ≥ 8 was the optimal cut-off point found (sensitivity 88.2%, specificity 86.6%, PPV 90.91%). The local version of PHQ-9 showed good ability to discriminate among depression severity categories according to the BDI-II scale. The best cut off points were 6-8 for mild cases, 9-14 for moderate and 15 or more for severe depressive symptoms respectively. Conclusions: The Argentine version of the PHQ-9 questionnaire has shown acceptable validity and reliability for both screening and severity assessment of depressive symptoms.
publishDate 2019
dc.date.none.fl_str_mv 2019-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147518
Urtasun, María; Daray, Federico Manuel; Teti, Germán Leandro; Coppolillo, Fernando Enrique; Herlax, Gabriela; et al.; Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina; BioMed Central; Bmc Psychiatry; 19; 1; 9-2019; 1-10
1471-244X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147518
identifier_str_mv Urtasun, María; Daray, Federico Manuel; Teti, Germán Leandro; Coppolillo, Fernando Enrique; Herlax, Gabriela; et al.; Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina; BioMed Central; Bmc Psychiatry; 19; 1; 9-2019; 1-10
1471-244X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-019-2262-9
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12888-019-2262-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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